高激发态核的多重碎裂

中能重离了反应后期高激发态核的多重碎裂可用量子统计模型来处理。不稳定的中等质量碎片将再次衰变成新的碎片多重性分布。由反应所发射的各种带电粒子数目间的比率标志的碎裂度可确定系统的熵，而由粒子不稳定碎片衰变的产额，可确定核系统的温度。     

30MeV/u40Ar+159Tb反应中中等质量碎片的发射时标与发射机制

报道30MeV/u⁴⁰Ar+¹⁵⁹Tb反应中碎片-碎片关联函数的实验结果．利用三体弹道模型从关联函数提取了中等质量碎片发射时间．中等质量碎片的平均发射时间随碎片能量而变化，从低能时的约500fm/c下降至高能时的约100fm/c．中等质量碎片发射时间随束流能量的升高而下降，表明随着束流能量的升高中等质量碎片发射机制逐渐从相继两体衰变向多重碎裂发射过渡．对于⁴⁰Ar+¹⁵⁹Tb反应，此过渡能区在35—45MeV/u之间 关键词：     

7Li和12C离子致DNA链断裂的研究

选用HI-13串列加速器产生的不同传能线密度的⁷Li和¹²C重离子,以不同的剂量对纯化的质粒DNA水溶液进行了辐照.利用原子力显微镜对这两种重离子诱发的DNA损伤进行了纳米水平的结构分析,并用ScionImage分析软件完成了DNA碎片长度的测量.得到了DNA分子超螺旋、开环和线性三种形态随剂量的变化情况以及DNA碎片长度的分布函数,并用Tsallis熵统计理论对实验结果进行了拟合.     

重离子辐射哺乳动物细胞敏感性的分子机理

研究了用传能线密度125.5keV/μm的12C6+辐照小鼠黑色素瘤、中国仓鼠肺、人的宫颈癌、人的肝癌细胞的敏感性以及DNA双链断裂和DNA双链断裂片段分布,结果表明细胞敏感性与DNA双链断裂之间没有一致的关系,提出了细胞辐射敏感性的一种可能的分子机理,即DNA序列敏感性位点协同DNA双链断裂互补性机理.由此解释了4种细胞系的不同敏感性问题. Four types of cells, melanoma B16, cervical squamous carcinima HeLa, Chinese hamster V79 and hepatoma SMMC 7721, were irradiated by 125.5 keV/μm carbon ions. Celullar sensitivities to irradiation indicated by D50 , DNA double strand break (DSB) and distribution of DSB fragments expressed by molecular weight are studied. The results show that there is not a consistent relationship between cellular sensitivity and DNA DSB induction, a possible molecular mechanism of radiosensitivity which...     

快中子辐照对枯草芽孢杆菌DNA损伤研究

采用脉冲场凝胶电泳技术检测并定量分析了CFBR-Ⅱ快中子脉冲堆产生的快中子在不同剂量和剂量率条件下, 对枯草芽孢杆菌黑色变种(ATCC 9372)DNA双链断裂的诱导. 通过DNA释放百分比PR值、DNA断裂水平L值、断裂DNA平均分子量和DNA片段分布等指标的分析, 结果表明：在不同的辐射条件下, DNA片段均明显分布于两个区域, 表明枯草芽孢杆菌黑色变种DNA分子上可能存在对中子辐射较为敏感的位点; 并且随着中子辐射剂量和剂量率的变化, DNA~释放百分比PR值、DNA断裂水平L值和各片段区双链断裂的含量也会发生一定规律性的变化.     

一类相空间中的准几率分布函数系

定义了一类相空间中的准几率分布函数系，这个准几率分布函数系直接建立在具有更加广泛意义的量子相空间Schr?dinger方程解的基础之上，其中定义_α=αp-i?q和_α=(1-α)q+i?p.发现了两个有趣的关系.(1)建立的量子相空间Schr?dinger方程的解实际上是对函数φ(λ)exp［i(1-α)qp］做窗口Fourier变换.(2)这个窗口函数g(λ)起着选择窗口形式的作用，而且不同的窗口对应着不同的分布函数.当g(λ)是一个代表Gauss窗的Gauss函数的时候，准几率分布函数就是一个类似于Husimi的分布函数f^HL_α(q,p)；当g(λ)是一个表示椭圆的复函数时，准几率分布函数就是一个椭圆分布函数f^E_α(q,p)；再在g(λ)为复函数的基础上附加α=0，就可得到标准序分布函数f^S(q,p)、反标准序分布函数f^AS(q,p)和Wigner分布函数f^W(q,p)，此时g(λ)表示高度为1/12π?而长度为λ的矩形窗. 关键词： 窗口Fourier变换 相空间 Wigner分布函数     

同位旋标度规律的动力学和统计衰变效应

通过同位旋相关的量子分子动力学模型和统计级联衰变模型, 计算了两个相似的同位旋不同的反应系统的同位旋标度规律, 计算的结果表明对于轻粒子碎片, 同位旋标度系数α随反应时间的增加有所变大, 而对于重的余核产物, α随反应时间的增加有所减小; 轻粒子碎片的α基本上保持不变化, 中等质量和重的余核, α与产物的大小相关, 产物越重α越大. 统计级联衰变可以稍微增加同位旋标度参数α, 但是不改变α对于轻粒子和重产物的变化规律.     

30MeV/u~(40)Ar ~(159)Tb反应中中等质量碎片的发射时标与发射机制

报道３０ＭｅＶ／ｕ４０Ａｒ＋１５９Ｔｂ反应中碎片碎片关联函数的实验结果．利用三体弹道模型从关联函数提取了中等质量碎片发射时间．中等质量碎片的平均发射时间随碎片能量而变化，从低能时的约５００ｆｍ／ｃ下降至高能时的约１００ｆｍ／ｃ．中等质量碎片发射时间随束流能量的升高而下降，表明随着束流能量的升高中等质量碎片发射机制逐渐从相继两体衰变向多重碎裂发射过渡．对于４０Ａｒ＋１５９Ｔｂ反应，此过渡能区在３５—４５ＭｅＶ／ｕ之间     

不同LET辐射致DNA集簇性损伤的研究

利用辐照质粒DNA构象变化的分子模型,以DNA糖苷酶Fpg和AP核酸内切酶EndoIII识别并切割辐射所致DNA碱基损伤,将其转换为DNA断裂损伤,通过电泳分析DNA分子构象变化,研究比较γ射线、质子和7Li离子诱发DNA集簇性损伤。50Gy以上高剂量γ辐射对质粒DNA的损伤主要表现为单链断裂(SSB)和很少比例的双链断裂(DSB),并能产生一定水平的集簇性损伤。相比之下,高能质子束和高LET的7Li离子直接所致DNA的断裂损伤以及所产生的集簇性碱基损伤比γ射线的要严重,质子10Gy照射就可诱发明显的集簇损伤。     

60AGeV 16 O诱发乳胶核反应α射弹碎片发射研究

对60AGeV^16O诱发乳胶核反应射弹α碎片的发射进行了研究，得到α射弹碎片多重数分布服从KNO标度无关性。在边缘作用下，α射弹碎片的产生与靶核碎片的产生存在线性关联，靶核碎片平均多重数随α射弹碎片数的增加线性减小，它可以很好地利用核作用几何模型来解释。     

DNA双链断裂产额的新算法

DNA双链断裂(DSB)的定量分析是高传能线密度辐射生物学效应机理研究的重要手段.从实际应用出发,推导了一个新的计算公式———平均分子量法.该法不探究DSB片段的具体分布模式,实际操作中却又包含了片段的含量和分布;而且形式简单、操作简便,尤其适合于荧光扫描数据. Quantitive analysis of DNA double strand break (DSB) is of importance for studying on the mechanisms of radiobiological effects induced by high linear energy transfer(LET) irradiation. For the practical use, one new calculating formula named the method of average molecular weight is deducted. In this method, the factual distribution of DSB fragments is not considered, but actually, the content and distribution of DSB fragments are included. Totally, this method is simple in shape and easy to use, esp...     

Plasmid DNA damage by heavy ions at spread-out Bragg peak energies

Interaction of ionizing radiation with plasmid DNA can lead to formation of single strand breaks, double strand breaks and clustered lesions. We have investigated the response of the synthetic plasmid pBR322 in aqueous solution upon irradiation with ¹²C ions under spread-out Bragg peak conditions (densely ionizing) and with ¹³⁷Cs γ-photons (sparsely ionizing) as a function of dose. To evaluate the relevance of indirect effects, i.e. influences of diffusion limited radical induced DNA damage triggered by water radiolysis, the experiments were performed at various concentrations of the radical scavenger mannitol. Agarose gel electrophoresis was employed to quantify the DNA damage. At low scavenger concentration for a given dose DNA damage is higher for γ-photons than for ¹²C. For the latter, the microscopic dose distribution is inhomogeneous, with very high dose deposited along the few tracks through the solution. This is in agreement with the concept that scavengers efficiently reduce damage for γ-photons, implying that the underlying damage mechanism is single strand break induction by OH radicals. For ¹²C induced damage, the fraction of SSB and DSB that is unaffected by radical scavengers and thus due to direct effect is quantified.     

Dynamics of superheavy system in 86Kr + 208Pb reaction

The dynamics of the excited superheavy system with Z = 118 in the reaction ⁸⁶Kr + Pb at E _Kr = 600 MeV has been investigated. The mass and kinetic energy of binary fragments were measured by the time-of-flight method. Double differential distributions of neutrons and α particles were measured in coincidence with fragments. Neutron and α-particle probes were used for determination of the fragmentation time scale. Evidence of the neck fragmentation was obtained from analysis of double differential α spectra. Properties of the α-particle neck fragmentation component are close to those known from the ternary fission of actinide nuclei, but the multiplicity is much larger. The total kinetic energy distribution of fragments tagged by neutrons or α particles shifts towards lower energies. Fragment yields in the symmetric region increase substantially when fragments are tagged by α particles.     

“Tunnelling” Black-Hole Radiation with ϕ 3 Self-Interaction: One-Loop Computation for Rindler Killing Horizons

Tunnelling processes through black hole horizons have recently been investigated in the framework of WKB theory discovering interesting interplay with the Hawking radiation. A more precise and general account of that phenomenon has been subsequently given within the framework of QFT in curved spacetime by two of the authors of the present paper. In particular, it has been shown that, in the limit of sharp localization on opposite sides of a Killing horizon, the quantum correlation functions of a scalar field appear to have thermal nature, and the tunnelling probability is proportional to exp{?β _Hawking E}. This local result is valid in every spacetime including a local Killing horizon, no field equation is necessary, while a suitable choice for the quantum state is relevant. Indeed, the two-point function has to verify a short-distance condition weaker than the Hadamard one. In this paper we consider a massive scalar quantum field with a ? ³ self-interaction and we investigate the issue whether or not the black hole radiation can be handled at perturbative level, including the renormalisation contributions. We prove that, for the simplest model of the Killing horizon generated by the boost in Minkowski spacetime, and referring to Minkowski vacuum, the tunnelling probability in the limit of sharp localization on opposite sides of the horizon preserves the thermal form proportional to exp{?β _H E} even taking the one-loop renormalisation corrections into account. A similar result is expected to hold for the Unruh state in the Kruskal manifold, since that state is Hadamard and looks like Minkowski vacuum close to the horizon.     

Radiobiological response of human hepatoma and normal liver cells exposed to carbon ions generated by Heavy Ion Research Facility in Lanzhou

Human hepatoma and normal liver cells were irradiated with ¹²C⁶⁺ ion beams (LET = 96.05 keV/μm) and γ-rays at Heavy Ion Research Facility in Lanzhou (HIRFL). The chromatid breaks and break types were detected using the premature chromosome condensation technique. Our experimental results showed that chromatid breaks seem to have a good relation with ¹²C⁶⁺ absorbed dose and ¹²C⁶⁺ are more effective to induce chromatid breaks as compared to the γ-rays. For ¹²C⁶⁺ ion irradiation the major break was isochromatid break, while chromatid breaks were dominant for γ-ray irradiation. We also observed that the Relative Biology Effectiveness (RBE) of ¹²C⁶⁺ ion is about 2.5 times higher than that of γ-rays.     

Proton spin-lattice relaxation in iron fluosilicate

Proton T₁ of FeSiF₆·6H₂O is proportional to exp (Δ/kT)at liquid helium temperatures, with Δ ≈ D - 3E. We find the crystal field splitting of the Fe²⁺ ion in this salt to be D = (12.2 ± 1.0) cm^-1 using E = 0.54 cm^-1.     

An improved model for band tail states inn-type degenerate semiconductors

Summary Using two screened donor potential energy models and a wave vectork-positionr uncertainty relation, the results of the exponential band tail states, inn-type degenerate semiconductors, obtained in our previous paper, are improved. The second-order cumulant or the correlation functionW (ϱ,E) is expressed as a function of the total donor concentration ϱ and total carrier energyE. Near band edges, the conduction and valence band tails are, respectively, proportional to exp [E/E ₀(ϱ)] and exp [−E/E ₀(ϱ)], whereE ₀(ϱ) is the energy characteristic of the appropriate band tail, in good accordance with those experimentally obtained by Pankove. Far below the conduction band edge, our result of the conduction band tail is proportional to exp [−BE ² exp [A ]], whereA andB are the functions of ϱ, which is reduced to zero more rapidly in comparison with the corresponding result obtained by Halperin and Lax (i.e. exp [−|E| ⁿ , wheren varies between 1/2 and 2). To speed up publication, the authors of this paper have agreed to not receive the proofs for correction.     

Calculation of quasi-stationary state parameters within the algebraic version of the resonating-group method

The dynamical equations of the algebraic version of the resonatinggroup method are used to determine the positionsE _res,l and the widths _l of quasi-stationary states or, what is equivalent, to find the polesE _l =E _resl –i _l /2 of theS-matrix in the fourth quadrant of thek-plane. Concrete calculations are performed for the -decay of⁸Be. A comparison with the results of other authors and with experiment is made.     

Mutagenic effect of accelerated heavy ions on bacterial cells

The heavy ion accelerators of the Joint Institute for Nuclear Research were used to study the regularities and mechanisms of formation of different types of mutations in prokaryote cells. The induction of direct (lac⁻, ton B⁻, col B) mutations for Esherichia coli cells and reverse his⁻ → His⁺ mutations of Salmonella typhimurium, Bacillus subtilis cells under the action of radiation in a wide range of linear energy transfer (LET) was studied. The regularities of formation of gene and structural (tonB trp-) mutations for Esherichia coli bacteria under the action of accelerated heavy ions were studied. It was demonstrated that the rate of gene mutations as a function of the dose under the action of Γ rays and accelerated heavy ions is described by linear-quadratic functions. For structural mutations, linear “dose-effect” dependences are typical. The quadratic character of mutagenesis dose curves is determined by the “interaction” of two independent “hitting” events in the course of SOS repair of genetic structures. The conclusion made was that gene mutations under the action of accelerated heavy ions are induced by δ electron regions of charged particle tracks. The methods of SOS chromotest, SOS lux test, and λ prophage induction were used to study the regularities of SOS response of cells under the action of radiations in a wide LET range. The following proposition was substantiated: the molecular basis for formation of gene mutations are cluster single-strand DNA breaks, and that for structural mutations, double-strand DNA breaks. It was found out that the LET dependence of the relative biological efficiency of accelerated ions is described by curves with a local maximum. It was demonstrated that the biological efficiency of ionizing radiations with different physical characteristics on cells with different genotype, estimated by the lethal action, induction of gene and deletion mutations, precision excision of transposons, is determined by the specific features of energy transfer of the radiations that affect the character of induced DNA damage, and the efficiency inducible and constitutive cell repair systems. The growth of relative biological efficiency of heavy charged particles is determined by the growth of the damage yield of the DNA participating in the formation of radiation-induced effects, and higher efficiency of inducible repair systems. It was established that the LET value (L _max) for which the maximum (according to the applied irradiation criteria) coefficients of relative biological efficiency are observed varies depending on the character of the registered radiation induced effect. It was demonstrated that for gene mutations and induction of precision excision of mobile elements the values of L _max are realized in a LET range of ≈20 keV/μm. For lethal effects of irradiation and induction of deletion mutations the value of L _max is ≈ 100 and 50 keV/μm, respectively. The differences in the L _max for the studied radiation gene effectis are determined by the different type of DNA damage participating in the mutation process. A molecular model of the formation of gene mutations in Escherichia coli cells under the action of ionizing radiation was proposed. Basic DNA radiation damage and main repair ways were considered in the framework of this model. The basis is the idea of the decisive role of mutagenic, error-prone, branch of SOS repair in fixing premutation DNA damage into point mutations. It was demonstrated that the central mechanism in this process is the formation of an inducible multi-enzymatic complex including the DNA polymerase V (Umu C), RecA-protease, SSB proteins, subunits of DNA polymerase III, performing erroneous DNA synthesis on the damaged matrix. A mathematical model of induction of gene mutations under ultraviolet cell irradiation was developed based on the molecular model.