共查询到18条相似文献,搜索用时 797 毫秒
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经新疆富科思生物技术发展有限公司科研人员的共同努力,成功研发了具有自主知识产权、光机电一体化的“光纤传感药物溶出度分析仪”。 相似文献
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采用硫酸显色法对两家药厂生产的阿奇霉素片及胶囊剂进行了溶出度考察。结果表明,阿奇霉素在10-100μg/mL范围内线性关系良好,平均 回收率为99.83%(n=6)。阿奇霉素片及胶囊剂在45min时的溶出量均不低于标示量的80%。而两厂产品体外溶出度结果均达到要求。 相似文献
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光纤药物原位溶出度/释放度监测仪实时监测复方氯唑沙宗片体外溶出度 总被引:1,自引:0,他引:1
研制了光纤-光学传感-药物溶出监测仪并应用于复方氯唑沙宗片的实时-原位体外溶出度.分支光纤的一端与光源相接,另一端与检测器连接,其公共端部探头浸入于盛于溶出杯中的溶解液中.借联机的计算机进行数据记录及处理,对复方氯唑沙宗片的组分对乙酰氨基酚和氯唑沙宗的回收率在低、中、高三个浓度水平进行了试验,结果依次为98.3%,102.3%和103.1%及108.6%,98.7%和97.7%,其相应的RSD值为1.0%,1.4%和0.4%及1.7%,1.6%及1.3%.应用此监测仪对药片的溶出全过程进行了监控,并显示了药物的溶解曲线,相关的溶出参数可随时提取.试验证明,使用该仪器可获得药物溶出全过程的真实情况的信息. 相似文献
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采用基于荧光猝灭原理的多通道光纤化学传感器连续在位监测固体制剂的体外溶出度。采用自制光纤荧光溶出度监测仪与ZRS-4型智能溶出仪联用,连续在位监测氧氟沙星片、甲硝唑片、呋喃妥因肠溶片的体外溶出度,溶出曲线经微机从五种常用数学模型中根据相关系数r值,优选最佳模型进行拟合。方法的回收率分别为97.4%-104.4%、97.4%-103.8%、96.6%-102.1%,日内、日间的RSD<5%。经与中国药典2000版方法及美国药典23版方法对照,各时间药物累积溶出量和拟合后提取的参数均无显著性差异(P>0.05)。 相似文献
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建立了阿司匹林双嘧达莫片溶出度和含量的测定方法。采用Amethyst C18-H色谱柱(4.6 mm×250 mm, 5μm),以磷酸盐缓冲液-甲醇-乙腈为流动相,梯度洗脱,流速1.0 mL/min,检测波长235 nm。溶出度实验采用篮法,以0.1 mol/L盐酸溶液和磷酸盐缓冲液(pH 6.8)为溶出介质。结果表明:溶出度实验中双嘧达莫、阿司匹林和水杨酸质量浓度分别在0.5508~49.57、1.668~150.1和0.2004~18.04μg/mL范围内线性关系良好(r2≥0.9998),回收率在97.7%~102.0%之间(RSD≤1.0%,n=6)。含量测定实验中阿司匹林和双嘧达莫质量浓度分别在29.71~267.4μg/mL和10.42~93.78μg/mL范围内线性关系良好(r2≥0.9999),回收率在98.1%~101.0%之间(RSD<1.0%,n=9)。本方法准确性好、精密度高、操作简单,适用于阿司匹林双嘧达莫片溶出度和含量测定。 相似文献
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The dissolution of the polar polymer, polyacrylamide (PAM), in water is studied kinetically. The rate of dissolution, ?, of PAM is determined by means of measuring the conductivity of water as dissolution of the polymer proceeds. The thickness of the swollen surface layer, δ, and the rate of swelling, ?, are determined with the aid of penetration and followed surface track by conductometric electrode. A kinetic equation reflecting PAM dissolution in water is obtained directly as 2? + ? = D?s/δ, where D?s is the average diffusion coefficient of solvent in polymer and is shown to be true in cases of nonpolar as well as polar polymers. © 1996 John Wiley & Sons, Inc. 相似文献
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H.G. Linge 《Advances in colloid and interface science》1981,14(4):239-250
The status of surface dissolution mechanisms for ionic crystals is surveyed. The mechanisms which best rationalize the unusual form of the experimental rate law for the surface dissolution of ionic crystals are described and compared. These mechanisms are effectively limited to the case of stoichiometric crystals dissolving in water. The electrochemistry of the crystal/solution interphase has not yet been satisfactorily introduced into crystal dissolution models and this extension needs more active and wider investigation. 相似文献
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P. Jara‐Ulloa P. Salgado‐Figueroa C. Yañez L. J. Núñez‐Vergara J. A. Squella 《Electroanalysis》2012,24(8):1751-1757
We report the adsorptive voltammetric determination of nifedipine on multiwalled carbon nanotubes (MWCNT)‐modified glassy carbon electrode (GCE). Nifedipine was adsorbed on the MWCNT and then reduced using linear sweep and cyclic voltammetry (LSV and CV). Parameters such as pH and accumulation time were tested. The MWCNT‐modified GCE showed enhanced currents and good signal‐to‐noise characteristics in comparison with the bare GCE. Consecutive measurements with the modified electrode were highly repeatable and reproducible. The MWCNT/GCE was used for the determination of nifedipine and is recommended for quantitation in dissolution test studies. In this study we have tested normal and extended‐release pharmaceutical formulations of nifedipine using USP apparatus 2 and tracking the released drug in solution by the proposed voltammetric method. The main advantage of the voltammetric determination is the feasibility to detect the drug in‐situ avoiding tedious intermediate steps such as filtration, collection and replenishment of sample solutions. This work seeks to demonstrate the feasibility of applying voltammetric techniques in dissolution test studies. 相似文献
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纤维素的绿色溶解体系 总被引:1,自引:0,他引:1
纤维素是一种天然的可再生资源,将其溶解是对其有效利用的关键。本文从溶解机理的角度对环境友好的非反应型纤维素溶剂,包括无机溶剂和有机溶剂体系,进行了重点介绍。无机溶剂体系包括碱/尿素/水体系、碱/硫脲/水体系等,其是在低温下通过尿素或硫脲小分子形成稳定的氢键网络包裹自由的纤维素大分子,使之不能相互结合,从而使碱不断打开纤维素分子间、分子内氢键获得更多的自由纤维素分子,并最终使其溶解。有机溶剂体系包括胺氧化物和离子液体,其是通过电子给予体和电子接受体与纤维素羟基作用实现纤维素的溶解。 相似文献
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Co‐polymeric hydrogels consisting of N‐vinyl‐2‐pyrrolidone (NVP) and acrylic acid (AAc) were synthesized and evaluated for release of a model drug, i.e., vitamin B12. Release studies in simulated gastric fluid (pH 1.2) and intestinal fluid (pH 7.4), at 37°C, showed the hydrogels to be pH sensitive. An in vitro release study by ‘traditional dissolution test’ (TDT) showed that percent drug released from the hydrogel was nearly 8.6±2.1 and 83.2±4.8 in the media of pH 1.2 and 6.8, respectively. However, in order to incorporate in vivo GI conditions such as acidic pH and high water content in the stomach, low water content and the presence of a semi–solid mass in the large intestine, a new test model, called flow through diffusion cell (FTDC) was also used. The two approaches yielded almost different release profiles. The gels were characterized by thermogravimetric analysis and FTIR spectroscopy. 相似文献
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J. P. Glatz I. Garcia-Alonso T. Kameyama L. Koch G. Pagliosa T. Tsukada H. Yokoyama 《Journal of Radioanalytical and Nuclear Chemistry》1996,203(1):11-18
In order to study the dissolution behavior of a highly burnt LWR fuel, a fuel pin irradiated in the DR3 test reactor in Risoe National Laboratory, has been characterized by microstructural examination and then dissolved under PUREX type conditions. The dissolution behavior was investigated and the residues analyzed by scanning electron microscopy and by ICP-MS and IDMS after dissolution. 相似文献