The polybuffer separation of the alkaloids of Vinca erecta

Summary By separating the total alkaloids ofV.erecta according to their basicities in an APS, in addition to bases known previously we have isolated ervincidine, apovincamine, (+)-quebrachamine, dl-eburnamine, (–)-1,2-dehydroaspidospermidine, and kopsanone. This is the first time that these alkaloids have been obtained from this plant. Thin-layer chromatography showed the presence of another 10–12 uncharacterized alkaloids.The region of the passage into the buffer solutions of some alkaloids has also been established.Institute of the Chemistry of Plant Substances, Academy of Sciences of the Uzbek SSR. Translated from Khimiya Prirodnykh Soedinenii, No. 6, pp. 713–717, November–December, 1970.     

Alkaloids ofAndrachne rotundifolia

Summary 1. The content of total alkaloids in the hypogeal parts ofAndrachne rotundifolia C. A. Mey. (family Euphorbicease) is 0.2–0.3% and in the epigeal parts 0.06–0.08%.The total alkaloids in both the hypogeal and the epigeal parts ofAndrachne rotundifolia consist of five or six non-phenolic bases.2. Three individual substances have been isolated: andrachnine C₁₁H₁₇NO₂, which is a new alkaloid; base (II), giving a perchlorate with mp 139°–140° C; and base (III) with mp 135°–136° C.Khimiya Prirodnykh Soedinenii, Vol. 2, No. 4, pp. 257–260, 1966     

The biosynthesis of the alkaloids of Goebelia pachycarpa

Summary 1. Qualitative and quantitative compositions of the main alkaloids in five development phases of theGoebelia pachycarpa C. A. Mey. have been determined.2. The radioactivities of the alkaloids isolated after feeding the plant with assumed precursors -[2-¹⁴C] lysine and [1,5-¹⁴C] cadaverine — show that vigorous synthesis of alkaloids takes place in the flowering and budding periods.3. The results of an investigation of the oxidation products and of the alkaloids introduced and isolated after the feeding of plants with labelled matrine and labelled sophocarpine show that the alkaloids undergo interconversion without intramolecular changes.V. I. Lenin Tashkent State University. Translated from Khimiya Prirodnykh, Soedinenii, No. 4, pp. 549–552, July–August, 1977.     

Alkaloids ofVeratrum,Petilium, andKorolkowia

The review is devoted to a study of the steroid alkaloids of plants of the generaVeratrum, Petilium, andKorolkowia. Characteristic reactions, spectra, and some chemical transformations of the alkaloids subdivided into groups according to structure are discussed. Some methods for determining their structures are considered.Institute of the Chemistry of Plant Substances, Academy of Sciences of the Uzbek SSR, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 1, pp. 3–22, January–February, 1980.     

Alkaloids of Papaver fugax

Papaver fugax growing on the shore of Lake Kazenoi Am in the Checheno-Ingushskii ASSR at the boundary with the Dagestan ASSR has yielded 0.39% of alkaloids. Seven alkaloids have been isolated, of which cheilanthifoline, scoulerine, and reticuline have been detected in this species for the first time, while it is the first time that d-remeroline has been found in a plant of thePapaver genus.Pyatigorsk Pharmaceutical Institute. Institute of the Chemistry of Plant Substances, Academy of Sciences of the Uzbek SSR, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 4, pp. 559–562, July–August, 1988.     

2,10-Didemethylcolchicine — A new alkaloid from Merendera robusta

The alkaloid complex ofMerendera robusta Bge. (familyLiliaceae) growing in the Tashkent province of the Uzbek SSR has been investigated. The main alkaloids of this plant are colchicine and colchamine. Eleven tropolone alkaloids and their photochemical isomers have been isolated and identified. A new alkaloid of phenolic nature has been isolated for which the structure of 2,10-didemethylcolchicine has been established.V. I. Lenin Tashkent State University. Translated from Khimiya Prirodnykh Soedinenii, No. 1, pp. 67–71, January–February, 1991.     

An investigation of the alkaloids of Lolium cuneatum

Summary In addition to three known alkaloids, the seeds ofL. cuneatum have yielded N-formylloline, N-acetylnorloline, and the new alkaloids N-methylloline and N-formylloline methiodide.Institute of the Chemistry of Plant Substances, Academy of Sciences of the Uzbek SSR, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 1, pp. 60–63, January–February, 1976.     

Alkaloids of Aconitum talassicum

Three new C-20 diterpene alkaloids (talassamine (I), talassimidine (II), and talassimine (III)) and the known alkaloid lappaconitine have been isolated from the epigeal part ofAconitum talassicum (Ranunculaceae). The structures of the new alkaloids proposed on the basis of spectral characteristics and chemical transformations have been confirmed by an x-ray structural analysis of talassimine.Institute of Chemistry of Plant Substances, Academy of Sciences of the Uzbek SSR, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 1, pp. 93–98, January–February, 1991.     

Alkaloids of four species of Argemone

The alkaloid compositions of four species of plants of the genusArgemone (A. mexicana L.,A. alba L.,A. platyceras Link et Otto., andA. hybrida) collected in the flowering phase in the Tashkent Botanical Garden have been studied. They have yielded 16 alkaloids. Corydine and isocorydine have been detected in plants of this genus for the first time, and O-methyl-platycerine has been found in nature for the first time.Institute of the Chemistry of Plant Substances, Academy of Sciences of the Uzbek SSR, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 2, pp. 204–206, March–April, 1986.     

Extraction of the total alkaloids from the epigeal part of Aconitum orientale

The process of extracting the total alkaloids fromAconitum orientale with aqueous solutions of a number of electrolytes has been investigated. It has been established that it is most desirable to use 2% solutions of H₂SO₄ and 5% solutions of CH₃COOH. The optimum parameters of the process have been found, under which the degree of extraction of the total alkaloids averages 96%.I. G. Kutateladze Institute of Pharmacochemistry, Georgian Academy of Sciences. Translated from Khimiya Prirodnykh Soedinenii, No. 6, pp. 816–821, November–December, 1991.     

Alkaloids ofColchicum luteum

The paper gives a review of the alkaloids ofColchium luteum Baker from various growth sites. The structure of luteidine — one of the main alkaloids of the plant — has been established. In addition, two new alkaloids have been isolated from the plant and the structure of one of them has been established as collutine N-oxide.M. I Kalinin Turkmen Agricultural Institute, Ashkhabad, and V. I. Lenin Tashkent State University. Translated from Khimiya Prirodnykh Soedinenii, No. 6, pp. 810–815, November–December, 1985.     

Berberis alkaloids. XV. Structure of bargustanine

Bargustanine (I), belonging to a new type of isoquinoline alkaloids, has been isolated from the phenolic fraction of the total alkaloids from the roots ofBerberis vulgaris L. Its structure has been established by chemical and spectral methods.Institute of Chemistry of Plant Substances, Uzbekistan Republic Academy of Sciences, Tashkent. Andizhan State Medical Institute. Translated from Khimiya Prirodnykh Soedinenii, No. 1, pp. 44–47, January–February, 1993.     

Determination of the position of the acyl groups and the nature of some amino alcohols in native ester alkaloids of the genusVeratrum

Conclusions 1. On the basis of literature data on the structure of theVeratrum alkaloids, a definite law for the arrangement of the acyl radicals in these ester alkaloids and an interrelationship between the melting point and the structure of the substituent in the C₇ position, and between the melting point and the types of amino alcohols upon which the ester alkaloids are based, has been found.2. The features mentioned may be used in studying the structure of theVeratrum ester alkaloids according to a scheme which we propose.Khimiya Prirodnykh Soedinenii, Vol. 6, No. 4, pp. 440–443, 1970     

Foliosidine acetonide

Summary Foliosidine acetonide has been isolated from the mixture of alkaloids fromH. foliosum.Institute of the Chemistry of Plant Substances, Academy of Sciences of the Uzbek SSR. Translated from Khimiya Prirodnykh Soedinenii, No. 6, pp. 724–727, November–December, 1970.     

An investigation of the alkaloids of Ammothamnus lehmanni the structure of lehmannine

Summary 1. The qualitative and quantitative composition of the combined alkaloids from the leaves, stems, seeds, and roots ofAmmothamnus lehmanni Bge. according to its vegetation periods have been studied.2. It has been found that the young plant contains predominantly the N-oxide forms of the matrine alkaloids, and as the plant develops these are reduced to the free bases.3. A new base lehmannine, C₁₅H₂₂ON₂ has been isolated for which 12,13-dehydromatrine is proposed as the most probable structure.V. I. Lenin Tashkent State University. Translated from Khimiya Prirodnykh Soedinenii, No. 3, pp. 377–380, May–June, 1975.     

Berberis alkaloids. XXII. Interbrinine and intebrimine — New alkaloids from Berberis integerrima

The known alkaloids reticuline, isoboldine, isocorydine, glaucine, armepavine, oxyacanthine, and heliamine and the new alkaloids intebrinine and intebrimine have been isolated from the total alkaloids of the leaves ofBerberis integerrima, and structures have been proposed for the latter two on the basis of spectral characteristics and independent synthesis.Andizhan State Medical Institute. Institute of the Chemistry of Plant Substances, Uzbekistan Republic Academy of Sciences, Tashkent. Translated from Khimiya Prirodnykh Soedeninii, No. 1, pp. 70–73, January–February, 1993.     

Applications of1H and13C NMR spectroscopy in structural investigations of Vinca indole alkaloids

This review considers the laws connecting the parameters of the¹H and¹³C NMR spectra with the structure of the substances and the use of these laws for solving structural and stereochemical problems of theVinca indole alkaloids and other compounds of closely related structure. For each type of alkaloids, characteristic features of the PMR and¹³C NMR spectra are given that permit the structures of similar bases to be established and their stereochemical identification to be performed.Institute of the Chemistry of Plant Substances, Academy of Sciences of the Uzbek SSR, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 1, pp. 3–15, January–February, 1986.     

The structure of pediculidine

Summary A new alkaloid pediculidine, C₁₀H₉NO, mp 74–75°C, has been isolated from the ethereal fraction of the combined alkaloids ofP. olgae. Structure (I) has been proposed for the new alkaloid on the basis of its UV, IR, NMR, and mass spectra.Order of the Red Banner of Labor Institute of the Chemistry of Plant Substances of the Academy of Sciences of the Uzbek SSR. Translated from Khimiya Prirodnykh Soedinenii, No. 3, pp. 304–306, May–June, 1971.     

Alkaloids from some species of Papaver and Roemeria,and the structure of Fugapavine

Summary Papaver cumrautatum Fisch. et Mey contains papaverine. FromPapaver fugax Poir we isolated armepavine, floripavine, and two new alkaloids, (+)-isoroemerine and fugapavine, which is 5,6-(methylenedioxy)-3-oxoaporphine.Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 3, pp. 502–509, March, 1965