后MOOC时期高职分析化学混合式教学模式构建

为了全面提高后MOOC时期的高职院校分析化学课程教学质量，提出了基于SPOC的分析化学课程混合式教学模式。首先分析了高职学生的特点和分析化学课程教学中的主要问题；然后根据基于SPOC的混合式教学模式构建流程，依次阐述了课程分析、整体设计、资源开发、教学过程和评价考核设计的原则与思路；最后探讨了基于翻转课堂的分析化学课程混合式教学环境与实施过程。     

生源多样化背景下医药卫生类高职分析化学教学改革实践

为提高医药卫生类高职院校专业人才培养质量,针对生源多样化情况下的分析化学课程进行教学改革探索。围绕教师教材教法,从优化理论教学资源、构建实践实训平台、课程思政元素应用、教师教学创新能力培养等方面开展建设,深度融合信息技术,助推高职学生自主、泛在、个性化学习,形成了培育学生成就教师的良性循环,改进了医药卫生类高职院校分析化学课程教学效果。为生源多样化背景下职业教育相关专业理论性较强的基础课程教学改革提供了参考。     

基于Excel的分析化学实验课程成绩评价系统构建与应用

借助Excel的自编公式、IF函数和跨工作表求和功能构建了分析化学实验课程成绩评价系统,研究了分析化学实验课程成绩评价系统的影响指标和指标权重,并运用该系统对学生课程成绩进行了评价,效果良好。     

高职院校企业化课堂管理的效果评价——以有机化学课为例

随着职业教育的快速发展,高职院校转型发展势在必行。将企业化管理模式应用到高职院校的课堂管理中,通过观念转变、角色转变、制度转变对此管理模式进行了分析;并以有机化学课为例,运用模糊层次分析法对其管理效果进行客观、科学地评价。结果表明企业化课堂管理模式能较好地适应高职院校转型发展的需要,对其教学改革具有一定的参考价值。     

新建师范院校分析化学精品课程的建设与实践

结合学校分析化学精品课程建设的实践,从课程目标制定、课程师资建设、课程体系和教学内容优化、教学方法和手段转变、课程资源开发、教学评价变革等方面对课程建设情况进行了描述。     

分析化学课程思政建设的举措

为全面推进课程思政建设,实施教学改革势在必行。本文基于分析化学学科特点以及课程培养目标,从提高教师思政教育能力、构建课程思政体系、深挖分析化学课程思政元素、优化教学评价四个方面出发,提出了全面推进分析化学课程思政建设的一些举措,以促进课程思政有效融入课堂。将思政教育与专业知识进行融合,有利于学生在掌握分析化学理论知识和操作技能的同时,培养以爱国主义为核心的民族精神和以改革创新为核心的时代精神,树立唯物主义的辩证思维、严谨认真和求真务实的科学态度、科学发展观等,形成广泛的课程思政理念共识并深入人心,从而实现教书与育人、立德与树人的有机统一。     

高职专业课的课程思政教学探索与实践——以“配位化合物”的思政教学为例

以医学专业医用化学课程的重难点内容“配位化合物”的思政为例,从教学实施、教学评价及教学反馈等3个方面探讨了高职院校专业课程的思政教学,以期为高职院校开展以课程思政为理念的课堂教学改革提供借鉴。     

高职《高聚物合成技术》课程项目化教学改革研究

通过对国家骨干高职院校建设项目之课程建设的探索,从课程体系的整合、课程标准的更新、课程项目内容的选择与实施、考核评价体系的建立以及资源库建设等方面,阐述了目前我院《高聚物合成技术》专业课程项目化教学改革的具体思路及做法,体现了工学结合项目化教学改革对学生职业技能培养的重要性,旨在通过加强课程建设,优化课程结构,创设工学...     

高职高专药学专业分析化学教学改革的探索与实践

针对分析化学课程教学中存在的问题,结合课程特点和专业人才培养目标,从基于专业特色设置课程、有针对性地展开教学、完善教学评价模式、提高教学资源利用率等4个方面对分析化学教学改革进行了探索。     

高职无机及分析化学实验教学改革探讨

简要阐述了高职院校无机及分析化学实验教学中存在的主体地位不突出、教学模式陈旧、师资力量薄弱、忽视职业素质培养等问题，提出转变教学思想、开展岗位调查、整合教学内容、改革教学策略、改进考核方法等具体的改革思路。认为高职无机及分析化学实验教学应以培养学生职业素质为核心。     

二氧化碳和丙烯直接合成甲基丙烯酸的NiPMo/TiO2催化剂的研究

用溶胶-凝胶法以磷钼酸(MPA)的镍盐溶液水解钛酸四丁酯制备了NiPMo/TiO2催化剂.使用ICP、 XRD、 TG-DTA、 IR、 TPD-MS和微反应技术研究了催化剂的化学组成、热稳定性、化学吸附性质和催化反应性能.杂多钼酸盐与TiO2通过O2-在TiO2表面发生了键合.在623 K下,杂多阴离子仍保持原有的Keggin结构.CO2在Lewis酸位Ni(Ⅱ)和Lewis碱位Ni-O-Mo的桥氧协同作用下生成CO2卧式吸附态Ni(Ⅱ)←O-(CO)←(O--Ni).丙烯有多种吸附态在催化剂上吸附.在563 K、 1 MPa和空速1500 h-1的反应条件下,丙烯的摩尔转化率为3.2%,产物MAA选择性为95%.     

α-Amino acid derived enaminones and their application in the synthesis of N-protected methyl 5-substituted-4-hydroxypyrrole-3-carboxylates and other heterocycles

A new and simple synthesis of novel N-protected methyl 5-substituted-4-hydroxypyrrole-3-carboxylates, which exist in equilibrium with their 4-oxo tautomers, has been developed in two steps starting from N-protected α-amino acids. The key intermediates are enaminones, which can also be isolated, characterized, and used for the construction of other functionalized heterocycles, before they spontaneously decompose to pyrrole products. 4-Hydroxypyrroles are prone to partial aerial oxidation but can be efficiently alkylated or reduced to stable polysubstituted pyrrolidine derivatives.     

Specific intramolecular aromatic CH insertion of diazosulfonamides

The chemoselectivity in the intramolecular CH insertion of various diazosulfonamides has been experimentally studied. The results reveal that the aliphatic 1,4-, 1,5-, or 1,6-C(sp³)?H insertions of diazosulfonamides are not accessible, while the aromatic 1,5-C(sp²)?H insertion can be realized specifically by adjusting the diazo-adjacent group. In addition, the general chemoselectivities in the intramolecular CH insertions of diazosulfonyl compounds are summarized. Generally, diazosulfones undergo both aromatic 1,5-C(sp²)?H and aliphatic 1,5- and 1,6-C(sp³)?H insertions, while diazosulfonates undergo aliphatic 1,5- and 1,6-C(sp³)?H insertions. However, diazosulfonamides only undergo aromatic 1,5-C(sp²)?H insertion.     

Toward new camptothecins. Part 6: Synthesis of crucial ketones and their use in Friedländer reaction

In the context of the preparation of camptothecin and luotonin A analogs, the synthesis of some key keto-precursors and their use in Friedländer condensation are described. This paper also focuses on the stability of these keto intermediates and emphasizes the major differences between indolizinones and pyrroloquinazolinones series. Noteworthy is also the report of some original structures isolated as by-products of some experiments.     

N-Heterocyclic carbene-palladacyclic complexes: synthesis,characterization and their applications in the C-N coupling and α-arylation of ketones using aryl chlorides

N-Heterocyclic carbene-palladacyclic complexes 3 were successfully achieved in a one-pot procedure under mild conditions. The structure of 3a was unambiguously confirmed by X-ray single crystal diffraction and it was an active catalyst in the Buchwald-Hartwig amination and α-arylation of ketones even at very low catalyst loadings (0.01?mol%).     

Iodine-mediated oxidative Pictet-Spengler reaction using terminal alkyne as the 2-oxoaldehyde surrogate for the synthesis of 1-aroyl-β-carbolines and fused-nitrogen heterocycles

An efficient iodine-mediated oxidative Pictet-Spengler reaction in dimethyl sulphoxide (DMSO) using terminal alkynes as the 2-oxoaldehyde surrogate for the synthesis of aryl (9H-pyrido[3,4-b]indol-1-yl)methanones is described. The scope of the protocol includes the total synthesis of Fascaplysin, Eudistomins Y₁ and Y₂. The methodology is extended for preparing pyrrolo[1,2-a]-quinoxaline and indolo[1,5-a]quinoxaline derivatives. The utility of 1-aroyl-β-carbolines was demonstrated by performing palladium-catalyzed β-carboline directed ortho-C(sp2)-H functionalization of the phenyl ring with thiomethyl (SMe) group using DMSO as source and for accessing 4-aryl-canthin-6-ones.     

Facile synthesis of bicyclic 1-arylpyrazol-5-ones

In this Letter, we described a facile method for constructing fused bicyclic 1-arylpyrazol-5-one ring system. We employed various methylene-containing carboxylic acids as the substrates and proved that the pyrazolone ring closure requires activated methylene group in intermediate II. Accordingly, a series of structurally diversified, fused bicyclic 1-arylpyrazol-5-ones was prepared in moderate to high yields using the requisite substrates.     

CoFe2O4自形成磁性液体场致结构化对磁化的影响

The Langevin paramagnetic theory can’t describe the relation between magnetization of ferrofluids and applied magnetic field. The structuralization of ferrofluids, which is considered the main influence factor of the magnetization, is regarded. The part of magnetization works is deposited when the structure is forming. This action influences the magnetization of ferrofluids directly or indirectly. On the base of the “compressing” model, the Langevin function that usually describes the magnetization of ferrofluid is modified, and a well-fitted curve is obtained. An equation of the relation between the equivalent volume fraction after being “compressed” and the intensity of magnetic field is discovered, which approximately describes the process of magnetization. The relation between the approximate initial susceptibility and the volume fraction can be obtained from modified formula.     

KMnO4-mediated oxidative CN bond cleavage of tertiary amines: Synthesis of amides and sulfonamides

KMnO₄-mediated oxidative CN bond cleavage of tertiary amines producing secondary amine was introduced, which was trapped by electrophiles (acyl chloride and sulfonyl chloride) to form amides and sulfonamides. The reaction could take place at mild condition, tolerating a wide range of function groups and affording products in moderate to excellent yields.     

Highly regioselective Buchwald–Hartwig amination at C-2 of 2,4-dichloropyridine enabling a novel approach to 2,4-bisanilinopyridine (BAPyd) libraries

The highly regioselective Buchwald–Hartwig amination at C-2 of the cheap and readily accessible reagent, 2,4-dichloropyridine with a range of anilines and heterocyclic amines is described. This new methodology is robust and provides a facile access to 4-chloro-N-phenylpyridin-2-amines on 0.25 mol scale. These intermediates undergo a further Buchwald–Hartwig amination at higher temperature to enable rapid exploration of the chemical space at C-4 and to provide a library of 2,4-bisaminopyridines.