Weighted Empirical Likelihood Ratio Confidence Intervals for the Mean with Censored Data

We propose a procedure to construct the empirical likelihood ratio confidence interval for the mean using a resampling method. This approach leads to the definition of a likelihood function for censored data, called weighted empirical likelihood function. With the second order expansion of the log likelihood ratio, a weighted empirical likelihood ratio confidence interval for the mean is proposed and shown by simulation studies to have comparable coverage accuracy to alternative methods, including the nonparametric bootstrap-t. The procedures proposed here apply in a unified way to different types of censored data, such as right censored data, doubly censored data and interval censored data, and computationally more efficient than the bootstrap-t method. An example of a set of doubly censored breast cancer data is presented with the application of our methods.     

Empirical likelihood inference for censored median regression model via nonparametric kernel estimation

An alternative to the accelerated failure time model is to regress the median of the failure time on the covariates. In the recent years, censored median regression models have been shown to be useful for analyzing a variety of censored survival data with the robustness property. Based on missing information principle, a semiparametric inference procedure for regression parameter has been developed when censoring variable depends on continuous covariate. In order to improve the low coverage accuracy of such procedure, we apply an empirical likelihood ratio method (EL) to the model and derive the limiting distributions of the estimated and adjusted empirical likelihood ratios for the vector of regression parameter. Two kinds of EL confidence regions for the unknown vector of regression parameters are obtained accordingly. We conduct an extensive simulation study to compare the performance of the proposed methods with that normal approximation based method. The simulation results suggest that the EL methods outperform the normal approximation based method in terms of coverage probability. Finally, we make some discussions about our methods.     

区间数据均值的经验似然估计

本文提出了估计区间数据均值的经验似然方法,通过构造区间数据的无偏转换,导出了渐近服从χ2分布的对数经验似然函数,从而得到了均值的置信区间.通过若干模拟例子说明,用本文提出的方法得到的估计,优于用渐近正态法得到的估计.     

Empirical Likelihood Semiparametric Regression Analysis under Random Censorship

This paper considers large sample inference for the regression parameter in a partly linear model for right censored data. We introduce an estimated empirical likelihood for the regression parameter and show that its limiting distribution is a mixture of central chi-squared distributions. A Monte Carlo method is proposed to approximate the limiting distribution. This enables one to make empirical likelihood-based inference for the regression parameter. We also develop an adjusted empirical likelihood method which only appeals to standard chi-square tables. Finite sample performance of the proposed methods is illustrated in a simulation study.     

Asymptotic distribution of the nonparametric distribution estimator based on a martingale approach in doubly censored data

For analysis of time-to-event data with incomplete information beyond right-censoring, many generalizations of the inference of the distribution and regression model have been proposed. However, the development of martingale approaches in this area has not progressed greatly, while for right-censored data such an approach has spread widely to study the asymptotic properties of estimators and to derive regression diagnosis methods. In this paper, focusing on doubly censored data, we discuss a martingale approach for inference of the nonparametric maximum likelihood estimator (NPMLE). We formulate a martingale structure of the NPMLE using a score function of the semiparametric profile likelihood. Finally, an expression of the asymptotic distribution of the NPMLE is derived more conveniently without depending on an infinite matrix expression as in previous research. A further useful point is that a variance-covariance formula of the NPMLE computable in a larger sample is obtained as an empirical version of the limit form presented here.     

截断情况下线性回归模型响应变量均值的经验似然

本文讨论了在带有截断情况的线性回归模型中 ,响应变量均值的估计问题 .将经验似然的方法应用到带有截断情况的回归模型中 ,在估计响应变量的均值时构造了调整的经验似然统计量 ,证明了在一定的条件下 ,该统计量渐近服从 χ2 分布 ,给出了均值的置信区间 ,并与正态下得到的结果进行了比较 ,模拟的结果说明了经验似然的优良性 .     

基于左截断右删失数据的单参数Pareto分布参数估计

基于EM算法及极大似然法研究了左截断右删失数据下单参数Pareto分布的参数估计,导出其迭代式,并应用随机模拟对参数估计式进行了模拟检验,结果表明迭代式能够快速收敛,EM估计值较为精确.     

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??In survival analysis, most existing approaches for analysing right-censored failure time data assume that the censoring time is independent of the failure time. However, investigators often face problems involving dependent censoring, i.e., failure time and censoring time are possibly dependent and they may be censored one another, especially in clinical trials. Without accounting for such dependence, survival distributions cannot be estimated consistently. Numerous attempts to model this dependence have been made. Among them, copula models are of particular interest because of their simple structure. Proportional hazard model analysis for informative right-censored data has been discussed in this paper. An Archimedean copula is assumed for the joint distribution function of failure time and censoring time variables. Under the conditions of identifiability of the parameter of the Archimedean copula, the maximum likelihood estimators of the parameter of Archimedean copula, the parameters and the cumulative hazard function of PH model are worked out. Extensive simulation studies show that the feasibility of the proposed method and the consistency of the estimators.     

截断与删失数据的极大似然估计的中偏差

本文研究了截断与删失模型,运用Taylor渐近展开方法,得到模型的极大似然估计的中偏差,比渐近正态性结果更加精细.     

左截断右删失数据分位差估计及其渐近性质

我们研究了左截断右删失数据分位差,基于左截断右删失数据乘积限构造了分位差的经验估计,同时克服经验估计的非光滑性,提出了分位数差的核光滑估计.利用经验过程理论推导出这两个估计的渐近偏差和渐近方差,并且在左截断右删失数据下研究了这两个分位差的大样本性质,获得分位差估计的相合性和渐近正态性.同时给出计算模拟以验证光滑分位差估计的表现,在均方损失的意义下模拟结果表明光滑估计比经验估计具有更好的性质.     

A New Approach to Censored Quantile Regression Estimation

Quantile regression provides an attractive tool to the analysis of censored responses, because the conditional quantile functions are often of direct interest in regression analysis, and moreover, the quantiles are often identifiable while the conditional mean functions are not. Existing methods of estimation for censored quantiles are mostly limited to singly left- or right-censored data, with some attempts made to extend the methods to doubly censored data. In this article, we propose a new and unified approach, based on a variation of the data augmentation algorithm, to censored quantile regression estimation. The proposed method adapts easily to different forms of censoring including doubly censored and interval censored data, and somewhat surprisingly, the resulting estimates improve on the performance of the best known estimators with singly censored data. Supplementary material for this article is available online.     

右删失数据下非线性回归模型的经验似然推断

考虑随机右删失数据下非线性回归模型,提出了模型中未知参数的调整的经验对数似然比统计量.在一定的条件下,证明了.所提出的的统计量具有渐近χ~2分布,由此结果构造了兴趣参数的置信域.通过模拟研究,对经典的经验似然、调整的经验似然和非线性最小二乘方法在有限样本下进行了比较,并对氯离子浓度试验数据进行了分析.     

Empirical likelihood inference for median regression models for censored survival data

Recent advances in median regression model have made it possible to use this model for analyzing a variety of censored survival data. For inference on the model parameter vector, there are now semiparametric procedures based on normal approximation that are valid without strong conditions on the error distribution. However, the accuracy of such procedures can be quite low when the censoring proportion is high. In this paper, we propose an alternative semiparametric procedure based on the empirical likelihood. We define the empirical likelihood ratio for the parameter vector and show that its limiting distribution is a weighted sum of chi-square distributions. Numerical results from a simulation study suggest that the empirical likelihood method is more accurate than the normal approximation based method of Ying et al. (J. Amer. Statist. Assoc. 90 (1995) 178).     

具有随机右删失随机变量分位数的经验似然推断

本文研究了具有随机右删失随机变量分位数的置信域的构造.利用经验似然和截尾值估算相结合的方法,给出了分位数的对数经验似然比统计量,在较少的条件下证明了该统计量的极限分布为自由度为1的x~2分布.使得完全数据下的分位数的经验似然推断方法应用到非完全数据中.     

Empirical likelihood inference for linear transformation models

Empirical likelihood inference is developed for censored survival data under the linear transformation models, which generalize Cox's [Regression models and life tables (with Discussion), J. Roy. Statist. Soc. Ser. B 34 (1972) 187-220] proportional hazards model. We show that the limiting distribution of the empirical likelihood ratio is a weighted sum of standard chi-squared distribution. Empirical likelihood ratio tests for the regression parameters with and without covariate adjustments are also derived. Simulation studies suggest that the empirical likelihood ratio tests are more accurate (under the null hypothesis) and powerful (under the alternative hypothesis) than the normal approximation based tests of Chen et al. [Semiparametric of transformation models with censored data, Biometrika 89 (2002) 659-668] when the model is different from the proportional hazards model and the proportion of censoring is high.     

Empirical likelihood inference for censored median regression with weighted empirical hazard functions

In recent years, median regression models have been shown to be useful for analyzing a variety of censored survival data in clinical trials. For inference on the regression parameter, there have been a variety of semiparametric procedures. However, the accuracy of such procedures in terms of coverage probability can be quite low when the censoring rate is heavy. In this paper, based on weighted empirical hazard functions, we apply an empirical likelihood (EL) ratio method to the median regression model with censoring data and derive the limiting distribution of EL ratio. Confidence region for the regression parameter can then be obtained accordingly. Furthermore, we compared the proposed method with the standard method through extensive simulation studies. The proposed method almost always outperformed the existing method.     

艾拉姆咖分布参数的Bayes估计及检验

首先给出了艾拉姆咖分布在定数截尾场合下参数的极大似然估计;其次由"平均剩余寿命"的概念得到了参数的拟矩估计;然后取共轭先验分布给出了参数的经验Bayes估计、区间估计及假设检验;最后通过实例给出了不同截尾样本下参数的点估计和区间估计.     

右删失时间序列AR模型参数估计

通过Kaplan-Meier估计和Nelson-Aalen估计得到了平稳时间序列被另一平稳序列右删失下.AR模型的参数估计.首先,通过与完全数据下的参数估计进行对比,说明了两种估计方法的效果.然后,根据计算机模拟的样本量以及删失率的不同,对比了两种估计的优劣,并且模拟结果表明两种估计是有效的.     

Bayesian Inference and Prediction of Gaussian Random Fields Based on Censored Data

This work develops a Bayesian approach to perform inference and prediction in Gaussian random fields based on spatial censored data. These type of data occur often in the earth sciences due either to limitations of the measuring device or particular features of the sampling process used to collect the data. Inference and prediction on the underlying Gaussian random field is performed, through data augmentation, by using Markov chain Monte Carlo methods. Previous approaches to deal with spatial censored data are reviewed, and their limitations pointed out. The proposed Bayesian approach is applied to a spatial dataset of depths of a geologic horizon that contains both left- and right-censored data, and comparisons are made between inferences based on the censored data and inferences based on “complete data” obtained by two imputation methods. It is seen that the differences in inference between the two approaches can be substantial.     

Comparisons among some predictors of exponential distributions using Pitman closeness

The bias, mean squared error and likelihood optimality criteria are used frequently to compare estimators and predictors. Recently, the probability of nearness around a statistic (estimator or predictor) has received a considerable attention in the literature. In this article, we adopt the Pitman’s measure of closeness (PMC) as an optimality criterion to compare the maximum likelihood, best linear unbiased, best linear invariant, median unbiased and conditional median predictors of a future ordered statistic based on a type II censored sample from an exponential distribution with unknown scale parameter. Numerical computations of the PMC for all comparisons among these predictors are performed and presented.