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天然黄酮碳糖苷化合物特有的稳定性和显著的生物活性, 使其化学合成成为当今糖化学领域的研究热点之一. 本工作立体专一性地全合成了天然黄酮碳苷Parkinsonin B. 通过控制物质的量比, 首先高选择性合成了2-羟基-4,6-二甲氧基苯乙酮(3), 并与糖给体O-(2,3,4,6-四-O-苄基-α-D-葡萄糖基)三氯乙酰亚胺酯(7)发生立体专一性糖基化反应得到碳糖苷化合物8, 化合物8经查耳酮路线进而合成黄酮碳苷Parkinsonin B (1). 经IR, MS, 1H NMR及元素分析证实了产物及中间体的结构, 同时讨论了全合成反应的主要影响因素, 并对其1H NMR解析进行了探讨. 相似文献
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研究了穿心莲中抗血栓的活性成分. 应用AB-8大孔吸附树脂、聚酰胺柱色谱及薄层色谱进行分离, 应用波谱学(1H NMR, 13C NMR, DQFCOSY, TOCSY, HMQC, HMBC, NOESY等)方法进行结构鉴定. 分离得到两个黄酮苷类化合物, 确定了1H NMR, 13C NMR信号的全归属. 化合物1鉴定为5,4'-二羟基-7-甲氧基黄酮-6-O-β-D-葡萄糖苷, 化合物2鉴定为5,4'-二羟基-7-甲氧基黄酮-8-O-β-D-葡萄糖苷, 化合物1为首次从该植物中分得, 首次对两个化合物的碳谱和氢谱进行了全归属. 相似文献
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为改善二唑及三唑类化合物的生物活性, 设计合成了一系列多氟烷基乙基取代的1,3,4-噁二唑-2-硫酮6a~6l及1,2,4-三唑-5-硫酮类化合物9a~9l. 1H NMR, 19F NMR, IR和MS谱以及元素分析表征了它们的结构; 实验结果与Materials Studio 3.0中的Dmol3计算模块理论计算表明了唑环上的NH较之CONH中的NH更易进行烷基化反应. 相似文献
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采用微波和相转移催化法通过1-苯基-5-(4-苯基-1,2,4-三唑-5-巯基-3-甲硫基)四唑(2)与2-氯乙酰芳胺(3)反应高效、快速地合成了10种尚未见文献报道的1-苯基-5-[5-(芳胺羰基甲硫基)-4-苯基-1,2,4-三唑-3-甲硫基]四唑. 其结构经 IR, 1H NMR, 13C NMR 和元素分析表征. 生物活性实验结果表明, 该类化合物在较低浓度下部分化合物对小麦芽有很好的促进作用. 相似文献
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N-多氟烷基取代和葡萄糖基取代的1,2,4-三唑-5-硫酮类席夫碱的合成及其杀虫活性 总被引:3,自引:0,他引:3
为改善三唑类化合物的生物活性, 以3-苯基-4-氨基-1,2,4-三唑-5-硫酮为原料, 将其与芳香醛在冰醋酸体系中反应, 得到3-苯基-4-芳基亚甲氨基-1,2,4-三唑-5-硫酮类席夫碱(4a~4i). 在此基础上, 化合物4a~4i分别与多氟烷基碘代烷和溴代乙酰基葡萄糖反应合成了一系列1,2,4-三唑-5-硫酮类席夫碱的多氟烷基取代物5a~5r和葡萄糖基取代物6a~6d, 并用1H NMR, 19F NMR, IR和MS谱以及元素分析表征了它们的结构. 初步生物活性测试结果表明, 部分目标化合物具有明显的杀虫活性. 相似文献
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聚缩醛螺胞二醚的合成及结构表征 总被引:3,自引:0,他引:3
在I2催化剂的作用下, 利用苯甲醛与季戊四醇反应, 制备了聚缩醛螺胞二醚的模型化合物3,9-二苯基-2,4,8,10-四氧杂螺[5.5]十一烷(1). 在此基础上, 利用1,3-苯二甲醛与不同摩尔比的季戊四醇合成了化合物1,3-二(2,6-二氧杂-4,4-二羟甲基环己基)苯(2)和2,4,8,10-四氧杂-3,9-二(3'-甲酰基苯基)螺[5.5]十一烷(3). 化合物2与化合物3反应, 制成标题化合物聚缩醛螺胞二醚4, 收率为95.4%. 用FTIR, 1H NMR对化合物1~4的结构进行了表征. 发现在含有手性轴化合物1, 3, 4的1H NMR谱中, 4个亚甲基中的8个氢原子裂分为4组双峰, 而不含有手性轴化合物中的4个亚甲基中的8个氢原子不裂分, 是个单峰. 这种不同不是由于化合物中刚性环所致, 而是由于有无手性轴造成的. 相似文献
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以豆腐果苷为原料, 在冰醋酸催化下和邻苯二胺缩合生成中间体2-(4-β-D-吡喃阿洛糖苷-苯基)-苯并咪唑(2), 2与卤代烃在K2CO3作用下以乙醇为溶剂合成了一系列1-烃基-2-(4-β-D-吡喃阿洛糖苷-苯基)-苯并咪唑类化合物3a~3h. 新化合物2和3a~3h的结构经1H NMR, IR和MS (HRMS)确认, 并对2和3a~3h进行了药理活性筛选. 结果表明, 部分化合物具有良好的镇静活性; 其中化合物2 (100 mg•kg-1), 3f (100 mg•kg-1)与豆腐果苷相比较具有更强的药理活性. 相似文献
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Ozgur Ozay Mehmet Yildirim 《Phosphorus, sulfur, and silicon and the related elements》2017,192(3):307-315
Three novel fully substituted urea derivative cyclotriphosphazene compounds 5–7 were synthesized by alkyne-azide 1,3-dipolar cycloaddition reaction of propargyl substituted ureas 2–4 with hexaazide substituted cyclotriphosphazene 1 in the presence of Cu(I) catalyst. All compounds were characterized with spectroscopic techniques such as FT-IR, 1H, 13C, and 31P nuclear magnetic resonance and mass spectroscopy. Also, the usefulness of compounds 5–7 as anion carriers was investigated by 1H NMR spectroscopy. For this purpose, 1H NMR spectra of compounds 5–7 were recorded in the presence of tetrabutylammonium fluoride in DMSO-d6. It was determined, that the urea protons in the compounds interact with fluoride. 相似文献
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Two new coumarins, euonidiol (1) and euoniside (2), and a known flavone, luteolin 7-methyl ether, were isolated from the aerial parts of the plant Euonymus hamiltanianus Wall. All the compounds were characterized on the basis of spectral analysis viz. 1H NMR, 13C NMR, DEPT, IR, UV, ESI-MS, and elemental analysis.
Published in Khimiya Prirodnykh Soedinenii, No. 1, pp. 10–11, January–February, 2008. 相似文献
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Wei Liu Yanting Tang Yu Guo Bo Sun Hemin Zhu Yanyan Xiao Dandan Dong Cheng Yang 《应用有机金属化学》2012,26(4):189-193
Fourteen new ferrocene derivatives containing urea linker were synthesized from the reaction of ferrocenecarbonyl azide with aromatic amines. The structures of the synthetic compounds were confirmed by 1H NMR, 13C NMR, IR, mass spectrometry and elemental analysis. These organometallic compounds were evaluated by in vitro protease assay using fluorogenic substrate peptide, and several showed potent inhibition against HIV‐1 protease. Copyright © 2012 John Wiley & Sons, Ltd. 相似文献
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《Tetrahedron》2003,59(8):1283-1288
Substituted 3-amino-1H,3H-quinoline-2,4-diones react with urea in acetic acid to give novel 2,6-dihydro-imidazo[1,5-c]quinazoline-3,5-diones in high yields. The same compounds were obtained, albeit with small yields, from 3-chloro-1H,3H-quinoline-2,4-diones and urea. In the proposed reaction mechanism, a molecular rearrangement of the primarily formed mono-substituted urea takes place. The prepared 2,6-dihydro-imidazo[1,5-c]quinazoline-3,5-diones were characterized by their 1H, 13C, 15N NMR and IR spectra and atmospheric pressure chemical ionisation mass spectra. 相似文献
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Hong-Yu Fan 《Natural product research》2020,34(14):1962-1970
AbstractRegioselective synthesis of three novel palmitates of 20(R)-ginsenoside Rg3 was accomplished via a facile strategy, along with complete assignment of their 1H and 13C NMR resonances by 1D and 2D NMR (1H-1H COSY, DEPT 135, HSQC, HMBC, and NOESY) techniques. The derivatives were tested for in vitro anti-proliferative activities against pancreatic cancer PANC-1 cells. Compounds 2, 3, and 4 exhibited more potent activity than did 20(R)-ginsenoside Rg3. 相似文献
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A series of novel N-, S-, and O-substituted p-chloranil derivatives were synthesized from the reactions of p-chloranil (1) and related nucleophiles in sodium carbonate (Na2CO3) solution of acetonitrile or in chloroform with Et3N. The structures of novel compounds were characterized by using microanalysis, Fourier transform–infrared, 1H NMR, 13C NMR, and mass spectrometry. 相似文献
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Wei Wang Min-Zhen Mao Xiao-Guang Zhang Xiao-Rui Zheng Xiao-Ying Huang 《Phosphorus, sulfur, and silicon and the related elements》2018,193(3):164-167
A series of novel ethyl 2-(5-methyl-3-arylisoxazole-4-carboxamido)-4-alkylthiazole-5-carboxylates I-1-6 were synthesized. The structures of all target compounds were characterized by 1H NMR, 13C NMR, IR, MS and elemental analyses. Their fungicidal and herbicidal activities were evaluated. The results of preliminary bioassays show that the title compounds I-4 possess 20–50% inhibition against most of the tested plants at the dosage of 150 g ai/ha, while the title compounds I-1-5 possess 32–58% inhibition against FusaHum graminearum, Thanatephorus cucumeris, Botrytis cinereapers and Fusarium oxysporum in vitro at the concentration of 100 mg/L. 相似文献
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Navneet Kishore Bhuwan Bhushan Mishra Vinod Kumar Tiwari Vyasji Tripathi 《Chemistry of Natural Compounds》2010,46(4):517-519
A novel naphthoquinone (1) was isolated from the methanol extract of P. zeylanica roots in addition to a known compound plumbagin (2). Their structures were determined by UV, IR, MS, 1H, and 13C NMR spectroscopic analysis, including 2D NMR. 相似文献
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Synthesis of novel bis-(3-methyl-5-nitro-2-oxo-2,3-dihydro-2λ 5benzo[1,3,2]oxazaphosphol-2yl)substituted aryl methanes was accomplished by Pudovik reaction. Addition of equimolar quantities of 2-methylamino-4-nitro phenol (1) and ethanol to PCl3 afforded cyclic condensation product. On reaction with respective aldehydes followed by treatment with phosphorus(III) monochloride of 1, and on subsequent reaction at reflux temperature, this rearranged from P(III) to P(V) state. Their structures were determined by IR, 1H NMR, 13C NMR, 31P NMR, and mass spectral data. 相似文献
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Watchara Sangsopha Ratsami Lekphrom Somdej Kanokmedhakul 《Natural product research》2020,34(7):988-994
AbstractA new tocotrienol, 5-hydroxy-8-methyltocotrienol (1) was isolated from the roots and branches of A. cobbe (L.) Raeusch, together with seventeen known compounds (2–18). Their structures were elucidated by analysis of spectroscopic data and by comparison of 1H and 13C NMR data with previous literature reports. This is the first phytochemical investigation of the roots and branches of Allophylus cobbe (L.) Raeusch. 相似文献