微波作用下1-苯基-5-[5-(芳胺羰基甲硫基)-4-苯基-1,2,4-三唑-3-甲硫基]四唑的合成及生物活性

采用微波和相转移催化法通过1-苯基-5-(4-苯基-1,2,4-三唑-5-巯基-3-甲硫基)四唑(2)与2-氯乙酰芳胺(3)反应高效、快速地合成了10种尚未见文献报道的1-苯基-5-5-(芳胺羰基甲硫基)-4-苯基-1,2,4-三唑-3-甲硫基]四唑. 其结构经 IR, ¹H NMR, ¹³C NMR 和元素分析表征. 生物活性实验结果表明, 该类化合物在较低浓度下部分化合物对小麦芽有很好的促进作用.

Synthesis and Biological Activity of 1-Phenyl-5-[5-(substituted anili-nocarbonylmethylthio)-4-phenyl-1,2,4-triazol-3-ylmethylthio]-tetrazole

Ten novel derivatives of 1-phenyl-5-5-(substituted anilinocarbonylmethylthio)-4-phenyl-1,2,4- triazol-3-ylmethylthio]-tetrazole were synthesized rapidly in high yields by the reaction of N-(substituted phenyl)-2-chloryacetanilide (3) with 1-phenyl-5-(5-mercapto-4-phenyl-1,2,4-triazol-3-ylmethylthio)-tetrazo- le (2) under microwave irradiation and phase transfer catalysis conditions. Their structures were characterized by IR, ¹H NMR ,¹³C NMR spectra and elemental analysis. The plant growth regulating activity tests showed that some compounds have good activity at low concentrations as plant growth regulators.