硝酸铈对大鼠体内酯酶酶谱的影响

采用聚丙烯酰胺凝胶电泳技术，研究了含不同浓度的稀土饲料喂养大鼠对大鼠体内9种器官和组织中（心脏，肝脏，肾脏，肌肉，胃，血清，睾丸，胰腺，肺）酯酶酶谱的影响，结果表明：稀土的作用导致酯酶酶谱发生显著的变化，原有的一些谱带消失，出现了一些新的谱带，这种影响随器官和组织的不同而不同，谱带强度的改变也因器官和稀土浓度不同而异。特别是在心，肝，肾，肌，胃中酯酶（EST）同工酶酶谱和稀土的浓度之间具有一定的相关性，对酶活性起着抑制或和激活作用，面对血清，睾丸，胰腺，肺中EST同工酶的影响则相对较小，可见，稀土对大鼠体内酯酶酶谱的影响是广泛而显著的。     

反相液相色谱质谱法分离鉴定3,4,6,7,9,10-6H-3,3,6,6-四甲基-9-对硝基苯基吖啶-1,8二酮

应用反相高效液相色谱法，分离和鉴定3，4，6，7，9，10－6H－3，3，6，6－四甲基－9－对硝基苯基吖啶－1，8－二酮（化合物Ⅰ），分离系统包括Zorbax SB C18及苯基柱，紫外检测器检测波长为285nm，等比和线性梯度淋洗，液相色谱－质谱联用和光导二极和列检测系统被用来鉴定主要化合物及其它杂质，此方法可达到分离效果好，灵敏度高。     

稀土生物功能化合物的应用研究

稀土元素及其化合物对生物具有某些特殊的生理功能和生物效应，使其在农业，林业，牧草，畜牧业，水产养殖业，微生物和发酵工业，医药和临床方面的研究日前深入广泛，本文就目前国内外应用研究的进展作了概括综述。     

北京宏剑讯科软件技术有限公司常用化学软件

Gaussian03——业界应用最广泛的量子化学软件，是作半经验计算和从头计算使用最广泛的量子化学软件。可以研究：分子能量和结构，过渡态的能量和结构化学键以及反应能量，分子轨道，偶极矩和多极矩，原子电荷和电势，振动频率，红外和拉曼光谱，NMR，极化率和超极化率，热力学性质，反应路径。计算可以模拟在气相和溶液中的体系，模拟基态和激发态，还可以对周期边界体系进行计算。公司每月一期G03软件培训。     

脑卒中患者血清中8种必需微量元素水平的研究

１１０例脑卒中患者血清中铁，锌，铜，锰，硒，铬，钴，镍的含量水平与对照组比较，结果显示：１．血清的，铜和铬的含量升高，锌，钴和镍的含量降低，两者之间的差异均有高度显著性，Ｐ〈０．０１；２．血清锰和硒的含量与对照组差异无显著性，Ｐ〉０．０５；３．在临床上述元素含量变化可用于脑座中的辅助诊断和治疗。     

希土—芳香异羟肟酸荧光固态配合物的合成及其性质的研究

本文首次报道了十种三价希土（Ｌａ，Ｃｅ，Ｐｒ，Ｎｄ，Ｓｍ，Ｅｕ，Ｇｄ，Ｔｂ，Ｔｍ和Ｙ）离子与芳香异羟肟酸，即水杨酰异肟酸（ＳＨＡ），苯甲酰异羟肟酸（ＢＨＡ）和邻苯二甲酰异羟肟（ＯＰＨＡ）配合物的合成方法和性质，元素分析，热重一差热分析测定和证实了这些新型希土配合物的组成。对这些配合物进行了红外光谱，核磁共振谱和荧光光谱研究。实验证明，铕和铽的芳香异羟肟酸固态配合物有很好的荧光性质。对这些配合物...     

海带中生命元素的ICP—AES研究

应用ＩＣＰ－ＡＥＳ技术测定了Ｓｒ，Ｃａ，Ｍｇ，Ｐ，Ｆｅ，Ｃｕ，Ｍｎ和Ｚｎ等８种生命元素在海带中的分布，发现三种分布模式；（１）Ｆｅ，Ｃｕ，Ｍｎ，Ｚｎ在叶状体末端和边缘，固着器末端含量高，其余部位含量低；（２）Ｓｒ和Ｃａ的分布规律与第一类相似，但固着器基部高于固着器末端；（３）Ｍｇ和Ｐ均匀分布。     

Zr-Ni/Al2O3催化剂上苯由H2O2氧化直接氨基化制苯胺

用浸渍法制备了Ni／Al2O3和Zr-Ni／Al2O3催化剂，用于以过氧化氢为氧化剂的苯直接氧化胺化制苯胺反应，并对催化剂进行了程序升温还原、室温氧吸附和氢吸附及XRD表征，结果表明，我们所制的Ni基催化剂对苯胺的生成都有活性，加入Zr后，催化剂中Ni物种更分散，低温可还原物种增加，室温吸氧和吸氢能力都增强，反应活性和对目标产物的选择性增大，Zr一方面使Ni物种进一步分散，增大催化剂的吸氢量和表面可还原Ni物种，有利于C-H键的活化；同时Zr与Ni的相互作用，促进了低温可还原物种的生成，使催化剂室温吸氧量增大，有利于苯的氧化，这种Zr和Ni的协同作用提高了催化剂的活性和选择性，催化剂的制备方法影响Zr与Ni的协同作用，使含Zr的两个催化剂的活性和选择性显示出差异。     

用ICP研究鹿科动物骨质疏松症的微量元素特征

鹿科动物的骨质疏松症是近几年出现的一种疾病，它影响鹿的生长发育和繁殖，病重者死亡。我们采集梅花鹿和白唇鹿的毛，血样，用低温灰化方法和温法消解处理样品，用ＩＣＰ分析了毛，血清中微量元素的含量。病梅花鹿毛样中Ｍｇ，Ａｌ，Ｃａ，Ｔｉ，Ｆｅ，Ｃｕ，Ｚｎ的含量比正常组高，Ｔｉ，Ｃｕ，Ｚｎ的偏差率大于１５％，而Ｓｉ，Ｍｎ，Ｐ，Ｐ，Ａｇ，Ｂａ，Ｌａ，Ｃｅ，Ｐｂ比正常组低，Ｖ，Ａｇ，Ｂａ，Ｌａ，Ｃｅ，Ｐｂ存在...     

必需微量元素与儿童健康研究进展

就14种必需微量元素对儿童健康的利弊进行了综述，其中包括：铁、锌、锰、碘、铜和钼，铬、镍和钴，硒和锡，氟和钒，硅。必需微量元素与儿童生长发育息息相关，但过量则会对儿童产生不利影响。     

二氧化碳和丙烯直接合成甲基丙烯酸的NiPMo/TiO2催化剂的研究

用溶胶-凝胶法以磷钼酸(MPA)的镍盐溶液水解钛酸四丁酯制备了NiPMo/TiO2催化剂.使用ICP、 XRD、 TG-DTA、 IR、 TPD-MS和微反应技术研究了催化剂的化学组成、热稳定性、化学吸附性质和催化反应性能.杂多钼酸盐与TiO2通过O2-在TiO2表面发生了键合.在623 K下,杂多阴离子仍保持原有的Keggin结构.CO2在Lewis酸位Ni(Ⅱ)和Lewis碱位Ni-O-Mo的桥氧协同作用下生成CO2卧式吸附态Ni(Ⅱ)←O-(CO)←(O--Ni).丙烯有多种吸附态在催化剂上吸附.在563 K、 1 MPa和空速1500 h-1的反应条件下,丙烯的摩尔转化率为3.2%,产物MAA选择性为95%.     

α-Amino acid derived enaminones and their application in the synthesis of N-protected methyl 5-substituted-4-hydroxypyrrole-3-carboxylates and other heterocycles

A new and simple synthesis of novel N-protected methyl 5-substituted-4-hydroxypyrrole-3-carboxylates, which exist in equilibrium with their 4-oxo tautomers, has been developed in two steps starting from N-protected α-amino acids. The key intermediates are enaminones, which can also be isolated, characterized, and used for the construction of other functionalized heterocycles, before they spontaneously decompose to pyrrole products. 4-Hydroxypyrroles are prone to partial aerial oxidation but can be efficiently alkylated or reduced to stable polysubstituted pyrrolidine derivatives.     

Specific intramolecular aromatic CH insertion of diazosulfonamides

The chemoselectivity in the intramolecular CH insertion of various diazosulfonamides has been experimentally studied. The results reveal that the aliphatic 1,4-, 1,5-, or 1,6-C(sp³)?H insertions of diazosulfonamides are not accessible, while the aromatic 1,5-C(sp²)?H insertion can be realized specifically by adjusting the diazo-adjacent group. In addition, the general chemoselectivities in the intramolecular CH insertions of diazosulfonyl compounds are summarized. Generally, diazosulfones undergo both aromatic 1,5-C(sp²)?H and aliphatic 1,5- and 1,6-C(sp³)?H insertions, while diazosulfonates undergo aliphatic 1,5- and 1,6-C(sp³)?H insertions. However, diazosulfonamides only undergo aromatic 1,5-C(sp²)?H insertion.     

N-Heterocyclic carbene-palladacyclic complexes: synthesis,characterization and their applications in the C-N coupling and α-arylation of ketones using aryl chlorides

N-Heterocyclic carbene-palladacyclic complexes 3 were successfully achieved in a one-pot procedure under mild conditions. The structure of 3a was unambiguously confirmed by X-ray single crystal diffraction and it was an active catalyst in the Buchwald-Hartwig amination and α-arylation of ketones even at very low catalyst loadings (0.01?mol%).     

CoFe2O4自形成磁性液体场致结构化对磁化的影响

The Langevin paramagnetic theory can’t describe the relation between magnetization of ferrofluids and applied magnetic field. The structuralization of ferrofluids, which is considered the main influence factor of the magnetization, is regarded. The part of magnetization works is deposited when the structure is forming. This action influences the magnetization of ferrofluids directly or indirectly. On the base of the “compressing” model, the Langevin function that usually describes the magnetization of ferrofluid is modified, and a well-fitted curve is obtained. An equation of the relation between the equivalent volume fraction after being “compressed” and the intensity of magnetic field is discovered, which approximately describes the process of magnetization. The relation between the approximate initial susceptibility and the volume fraction can be obtained from modified formula.     

Iodine-mediated oxidative Pictet-Spengler reaction using terminal alkyne as the 2-oxoaldehyde surrogate for the synthesis of 1-aroyl-β-carbolines and fused-nitrogen heterocycles

An efficient iodine-mediated oxidative Pictet-Spengler reaction in dimethyl sulphoxide (DMSO) using terminal alkynes as the 2-oxoaldehyde surrogate for the synthesis of aryl (9H-pyrido[3,4-b]indol-1-yl)methanones is described. The scope of the protocol includes the total synthesis of Fascaplysin, Eudistomins Y₁ and Y₂. The methodology is extended for preparing pyrrolo[1,2-a]-quinoxaline and indolo[1,5-a]quinoxaline derivatives. The utility of 1-aroyl-β-carbolines was demonstrated by performing palladium-catalyzed β-carboline directed ortho-C(sp2)-H functionalization of the phenyl ring with thiomethyl (SMe) group using DMSO as source and for accessing 4-aryl-canthin-6-ones.     

Facile synthesis of bicyclic 1-arylpyrazol-5-ones

In this Letter, we described a facile method for constructing fused bicyclic 1-arylpyrazol-5-one ring system. We employed various methylene-containing carboxylic acids as the substrates and proved that the pyrazolone ring closure requires activated methylene group in intermediate II. Accordingly, a series of structurally diversified, fused bicyclic 1-arylpyrazol-5-ones was prepared in moderate to high yields using the requisite substrates.     

Highly regioselective Buchwald–Hartwig amination at C-2 of 2,4-dichloropyridine enabling a novel approach to 2,4-bisanilinopyridine (BAPyd) libraries

The highly regioselective Buchwald–Hartwig amination at C-2 of the cheap and readily accessible reagent, 2,4-dichloropyridine with a range of anilines and heterocyclic amines is described. This new methodology is robust and provides a facile access to 4-chloro-N-phenylpyridin-2-amines on 0.25 mol scale. These intermediates undergo a further Buchwald–Hartwig amination at higher temperature to enable rapid exploration of the chemical space at C-4 and to provide a library of 2,4-bisaminopyridines.     

Sulfur-directed metal-free and regiospecific methyl C(sp3)–H imidation of thioanisoles

Regiospecific and direct imidation of the methyl C(sp³)–H bond of thioanisoles is realized under mild and metal-free conditions with N-fluorobis(benzenesulfonyl)imide as an oxidant and nitrogen source. Proposed mechanism suggests that thionium ion intermediates and a Pummerer-type reaction are involved. The imidation has advantages such as high step-economy, excellent functionality tolerance, and regiospecificity, giving structurally diverse imidation products.