| 全血胆固醇、甘油三酯近红外光谱分析与模型优化 |
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| 引用本文： | 黄富荣,罗云瀚,郑仕富,陈哲.全血胆固醇、甘油三酯近红外光谱分析与模型优化[J].光学学报,2011(10). |
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| 作者姓名： | 黄富荣 罗云瀚 郑仕富 陈哲 |
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| 作者单位： | 暨南大学光电信息与传感技术广东普通高校重点实验室;暨南大学第一附属医院临床检验中心; |
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| 基金项目： | 国家863计划(2009AA04Z315); 广东省自然科学青年基金(S2011040001850,8151063201000017); 中央高校基本科研业务费专项资金(21611342)资助课题 |
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| 摘 要： | 为验证近红外光谱测量全血中胆固醇和甘油三酯的可行性,采用近红外透射光谱结合化学计量学方法建立胆固醇和甘油三酯定量分析模型。获取全血在近红外全波段800～2500nm范围的透射光谱后,通过采用间隔偏最小二乘法(iPLS)进行特征波段的选择实现对分析模型的优化。经优化后的胆固醇、甘油三酯分析模型的特征吸收波段分别为1650～1730nm和2260～2340nm,预测相关系数分别为0.79和0.865,预测均方根误差分别为0.5mol/kL和0.28mol/kL。研究结果表明近红外光谱技术可用于测量全血胆固醇、甘油三酯的含量,运用间隔偏最小二乘法可确定特征吸收波段和优化分析模型。
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| 关 键 词： | 近红外光谱术 全血 胆固醇 甘油三酯 间隔偏最小二乘法 |
Near-Infrared Spectroscopic Analysis and Model Optimization on Cholesterol and Triglyceride in Whole Blood |
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| Huang Furong Luo Yunhan Zheng Shifu Chen Zhe.Near-Infrared Spectroscopic Analysis and Model Optimization on Cholesterol and Triglyceride in Whole Blood[J].Acta Optica Sinica,2011(10). |
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| Authors: | Huang Furong Luo Yunhan Zheng Shifu Chen Zhe |
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| Institution: | Huang Furong1 Luo Yunhan1 Zheng Shifu2 Chen Zhe1(1Key Laboratory of Optoelectronic Information and Sensing Technologies of Guangdong Higher Education Institutes,Jinan University,Guangzhou,Guangdong 510632,China 2Clinical Laboratory Center,First Affiliated Hospital,China) |
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| Abstract: | The quantitative models of cholesterol and triglyceride analysis in whole blood are established by using near-infrared transmission spectroscopy combined with chemo-metrics methods.First the transmission spectra of whole blood in wavelength range of near infrared full spectrum(800~2500 nm) is acquired,and then the calibration models for cholesterol and triglyceride analysis are optimized by using interval partial least squares(iPLS).The results show that the optimal wave band of calibration models for chole... |
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| Keywords: | near infrared spectroscopy whole blood cholesterol triglyceride interval partial least square method |
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