| 电热原子吸收光谱法测定奥沙利铂中的铅和砷 |
| |
| 引用本文： | 熊敏,普绍平,刘春侠,贺与平,何素芳,单云.电热原子吸收光谱法测定奥沙利铂中的铅和砷[J].光谱实验室,2011,28(2):640-644. |
| |
| 作者姓名： | 熊敏 普绍平 刘春侠 贺与平 何素芳 单云 |
| |
| 作者单位： | 1. 昆明理工大学分析测试研究中心,昆明市学府路253号,650093
2. 昆明贵研药业有限公司,昆明市,660106 |
| |
| 基金项目： | 云南省级科研院所技术开发专项课题 |
| |
| 摘 要： | 采用电热原子吸收光谱法测定抗肿瘤新药奥沙利铂中的痕量铅和砷,实验优选了灰化、原子化的最佳温度条件,进行了加标回收实验和精密度实验,加标回收率铅在97.88%—103.96%之间,砷在92.12%—105.72%之间。奥沙利铂是含贵金属的原料药,价格昂贵,检测时不耗费大量的样品、降低成本很重要。本法取样量少,不需要高温灰化和繁琐的样品富集和前处理技术,简单的酸溶解处理配成溶液后,即可直接上机测定,试样中的有机成分在灰化阶段可被除去。
|
| 关 键 词： | 奥沙利铂 铅 砷 电热原子吸收光谱法 |
Determination of Lead and Arsenic in Oxaliplatin by Electrothermal Atomic Absorption Spectrometry |
| |
| XIONG Min,PU Shao-Ping,LIU Chun-Xia,HE Yu-Ping,HE Su-Fang,SHAN Yun.Determination of Lead and Arsenic in Oxaliplatin by Electrothermal Atomic Absorption Spectrometry[J].Chinese Journal of Spectroscopy Laboratory,2011,28(2):640-644. |
| |
| Authors: | XIONG Min PU Shao-Ping LIU Chun-Xia HE Yu-Ping HE Su-Fang SHAN Yun |
| |
| Institution: | XIONG Min PU Shao-Pinga LIU Chun-Xia HE Yu-Ping HE Su-Fang SHAN Yun(Research Center for Analysis and Measurement,Kunming University of Science and Technology,Kunming 650093,P.R.China)a(Kunming Guiyan Pharmaceutical Co.Ltd.,Kunming 650106,P.R.China) |
| |
| Abstract: | The trace levels of lead and arsenic in anti-cancer drug oxaliplatin were determined by electrothermal atomic absorption spectrometry.In the method,the best ashing and atomization conditions were optimized.Since the oxaliplatin was a kind of raw material medicine had precious metals and very expensive.It was important to reduce the cost of the determination and the amount of samples was needed without high-temperature ashing and the tedious sample pretreatment technology.The samples were dissolved by nitric... |
| |
| Keywords: | Oxaliplatin Lead Arsenic Electrothermal Atomic Absorption Spectrometry |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
