Synthesis,Characterization and Application of Cellulose Based Nano-Biocomposite Hydrogels |
| |
| Authors: | Samaneh Saber-Samandari Saeed Saber-Samandari Mustafa Gazi Fevzi Ç Cebeci Emad Talasaz |
| |
| Institution: | 1. Department of Chemistry , Eastern Mediterranean University , Gazimagusa , TRNC , Turkey;2. New Technologies Research Center , Amirkabir University of Technology , Tehran , Iran;3. Faculty of Engineering &4. Natural Sciences , Sabanci University , Tuzla , Istanbul , Turkey |
| |
| Abstract: | Nano-hydroxyapatite/cellulose-graft-polyacrylamide biocomposite hydrogels of different molar ratios were prepared to examine their potential application as a carrier for colon targeted drug delivery in vitro. The particle size of the synthesized nano-hydroxyapatite was found to be 122 nm. The swelling behavior of the composite hydrogels was observed in acidic and basic aqueous solution that simulated lower small intestine, colon and stomach fluids. The hydrogel could be applied in drug-delivery systems and acetylsalicylic acid was used as a model compound to test such a possibility. Finally, the synthesized biocomposite hydrogels with the 96.97% maximum encapsulation and 85.67% release efficiency in the basic medium were found to be a suitable candidate to carry and release of colon-targeted drugs. |
| |
| Keywords: | acrylamide cellulose composite hydrogel nano-hydroxyapatite |
|
|
