异三尖杉酯碱侧链酸的合成

本文报道了异三尖杉酯碱侧链酸(3)的立体选择性合成。(R,R)-(+)-酒石酸先制成酒石酸二甲酯缩丙酮(8), 然后经烷基化、构型转换、催化加氢、碱性水解、部分酯化和酸性水解, 首次成功地得到了预期产物3。

Synthesis of side chain acid of isoharringtonine

The stereocontrolled synthesis of side chain acid I of isoharringtonine from (R,R)-(+)-tartaric acid was reported. Thus, (R,R)-(+)-tartaric acid was converted to (2R,3R)-dimethyl tartrate acetonide, which then was transformed through alkylation, isomerization, hydrogenation, basic hydrolysis, partial esterification and acid hydrolysis to give the title compound I.