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The Combination of Benzaldehyde and Nickel‐Catalyzed Photoredox C(sp3)−H Alkylation/Arylation |
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| Authors: | Lumin Zhang Xiaojia Si Yangyang Yang Marc Zimmer Sina Witzel Kohei Sekine Matthias Rudolph A Stephen K Hashmi |
| Abstract: | Herein we report a highly selective photoredox C(sp3)?H alkylation/arylation of ethers through the combination of a photo‐organocatalyst (benzaldehyde) and a transition‐metal catalyst (nickel). This method provides a simple and general strategy for the C(sp3)?H alkylation/arylation of ethers. A selective late‐stage modification of (?)‐ambroxide has also been conducted to demonstrate the applicability of the method. |
| Keywords: | alkylation arylation benzaldehyde nickel catalysis photoredox reaction |