| 纤维素衍生物涂敷型高效液相色谱手性固定相的制备及手性拆分研究 |
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| 引用本文： | 侯经国,周宏英,蒋生祥,周志强,陈立仁,欧庆瑜.纤维素衍生物涂敷型高效液相色谱手性固定相的制备及手性拆分研究[J].高等学校化学学报,1998,19(4):538-542. |
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| 作者姓名： | 侯经国 周宏英 蒋生祥 周志强 陈立仁 欧庆瑜 |
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| 作者单位： | 中国科学院兰州化学物理研究所, 兰州, 730000 |
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| 摘 要： | 合成了纤维素-三(苯甲酯)(CTB)和纤维素-三(氨基苯甲酸酯)(CTPC)衍生物,并涂敷于自制的球形硅胶上(5μm,13nm),制备了用于高效液相色谱手性拆分的固定相.考察了涂敷量、流动相等因素对手性拆分的影响,测定了一个不对称氢化酯化反应的对映体过剩值(e.e.值).
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| 关 键 词： | 高效液相色谱 纤维素衍生物 手性固定相 手性拆分 不对称氢化酯化 |
| 收稿时间： | 1997-05-13 |
| 修稿时间： | 1997年5月13日 |
Preparation of Chiral Stationary Phases Coated Using Cellulose Derivatives and Study of Chiral Resolution in HPLC |
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| HOU Jing-Guo,ZHOU Hong-Ying,JIANG Sheng-Xiang,ZHOU Zhi-Qiang,CHEN Li-Ren,OU Qing-Yu.Preparation of Chiral Stationary Phases Coated Using Cellulose Derivatives and Study of Chiral Resolution in HPLC[J].Chemical Research In Chinese Universities,1998,19(4):538-542. |
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| Authors: | HOU Jing-Guo ZHOU Hong-Ying JIANG Sheng-Xiang ZHOU Zhi-Qiang CHEN Li-Ren OU Qing-Yu |
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| Institution: | Lanzhou Institute of Chemical Physics, Academia Sinica, Lanzhou, 730000 |
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| Abstract: | Optical resolution of a range of racemic compounds was investigated using cellulose tribenzate and trisphenylcarbamate coated onto a small partial spherical organosilane modified silica. The influence on chiral discrimination of factors such as coated loadings and mobile phase was performed. The loadings of 15% on the support gave the best results. The regioselectivity of an asymmetric hydroesterification of styrene was determined by HPLC using a chiral stationary phase(CTPC CSP). A satisfactory result had been obtained on CTPC chiral column with n hexane/2 propanol(98/2 in volume ratio) as mobile phase. |
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| Keywords: | HPLC Cellulose derivatives Chiral stationary phase Optical resolution Asymmetric hydroesterification |
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