| 丙酮酸乙酯多相不对称催化加氢反应的初始过渡期研究 |
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| 引用本文： | 陶国忠,卢冠忠,郭耘,王艳芹,郭杨龙,张志刚,刘晓晖,王筠松.丙酮酸乙酯多相不对称催化加氢反应的初始过渡期研究[J].催化学报,2009,30(5). |
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| 作者姓名： | 陶国忠 卢冠忠 郭耘 王艳芹 郭杨龙 张志刚 刘晓晖 王筠松 |
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| 作者单位： | 华东理工大学工业催化研究所结构可控先进功能材料及其制备教育部重点实验室,上海,200237 |
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| 基金项目： | 上海市科委纳米专项基金 |
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| 摘 要： | 采用奎宁修饰的Pt/Al2O3为催化剂,研究了在常压下,乙酸溶剂中丙酮酸乙酯的不对称加氢反应.考察了奎宁修饰剂浓度、反应温度、预修饰时间、底物起始浓度及氧的加入对内酮酸乙酯不对称氢化反应初始过渡期(ITP)特征的影响.结果表明,在不对称氢化反应的初期,存在对映选择性随底物转化率的增加而不断升高的现象(即ITP现象),反应条件的变化能不同程度地改变ITP特征,在奎宁修饰催化剂时加入O2能明显提高催化剂对产物的对映选择性,改善ITP现象.ITP特征取决于反应起始阶段反应体系中各组分在催化剂表面的相互作用及达到平衡的速度,其实质是手性修饰型催化剂表面的重排过程.
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| 关 键 词： | 丙酮酸乙酯 铂 氧化铝 奎宁修饰型催化剂 不对称加氢 初始过渡期 |
Studies on the Initial Transient Period of Heterogeneous Asymmetric Catalytic Hydrogenation of Ethyl Pyruvate |
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| TAO Guozhong,LU Guanzhong,GUO Yun,WANG Yanqin,GUO Yanglong,ZHANG Zhigang,LIU Xiaohui,WANG Yunsong.Studies on the Initial Transient Period of Heterogeneous Asymmetric Catalytic Hydrogenation of Ethyl Pyruvate[J].Chinese Journal of Catalysis,2009,30(5). |
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| Authors: | TAO Guozhong LU Guanzhong GUO Yun WANG Yanqin GUO Yanglong ZHANG Zhigang LIU Xiaohui WANG Yunsong |
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| Institution: | TAO Guozhong,LU Guanzhong,GUO Yun,WANG Yanqin,GUO Yanglong,ZHANG Zhigang,LIU Xiaohui,WANG Yunsong Laboratory for Advanced Materials,Research Institute of Industrial Catalysis,East China University of Science , Technology,Shanghai 200237,China |
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| Abstract: | The asymmetric hydrogenation of ethyl pyruvate over the Pt/Al2O3 catalyst modified by quinine was studied under atmospheric pressure in acetic acid.The effects of quinine modifier concentration,reaction temperature,pre-modification time,initial substrate concentra-tion,and O2 addition on the character of the initial transient period(ITP) of reaction were investigated.The results showed that the enanti-oselectivity of product gradually increases with the increase of the reactant conversion in the ITP of hydr... |
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| Keywords: | ethyl pyruvate platinum alumina quinine-modified catalyst asymmetric hydrogenation initial transient period |
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