A facility location and installation of resources model for level of repair analysis

The Level of Repair Analysis – LORA – is an analytic methodology aimed at determining: (i) the optimal location of facilities that compose a maintenance structure; (ii) the quantity of required resources in each facility; and (iii) the best repair policies, i.e., rules that determine if a given component should be discarded or repaired, and where those actions should take place. This work presents a mixed-integer programming model for LORA that is more comprehensive than others in the literature, being suitable to many practical situations. The model was applied to 15 substantial real world problems, and considering distinct maintenance policies to some of them, resulted in 22 different solutions, all of which could be achieved by a commercial Mixed-Integer Programming (MIP) solver in reasonable times.     

Extraction methods of red blood cell membrane proteins for Multidimensional Protein Identification Technology (MudPIT) analysis

Since red blood cells (RBCs) lack nuclei and organelles, cell membrane is their main load-bearing component and, according to a dynamic interaction with the cytoskeleton compartment, plays a pivotal role in their functioning. Even if erythrocyte membranes are available in large quantities, the low abundance and the hydrophobic nature of cell membrane proteins complicate their purification and detection by conventional 2D gel-based proteomic approaches. So, in order to increase the efficiency of RBC membrane proteome identification, here we took advantage of a simple and reproducible membrane sub-fractionation method coupled to Multidimensional Protein Identification Technology (MudPIT). In addition, the adoption of a stringent RBC filtration strategy from the whole blood, permitted to remove exhaustively contaminants, such as platelets and white blood cells, and to identify a total of 275 proteins in the three RBC membrane fractions collected and analysed. Finally, by means of software for the elaboration of the great quantity of data obtained and programs for statistical analysis and protein classification, it was possible to determine the validity of the entire system workflow and to assign the proper sub-cellular localization and function for the greatest number of the identified proteins.     

顺序式X射线荧光光谱仪常见故障的诊断方法

介绍顺序式X射线荧光光谱仪5种常见故障的诊断及处理方法。故障部位包括X射线装置、样品室和光谱室的真空、探测器、晶体和测角仪。     

光纤传感器测量FRP加固结构的损伤

A distributed fiber optic sensor is developed for condition monitoring of civil infrastructure sys-tems. The fiber optic sensor is especially useful in applications involving structures strengthened by fiberreinforced polymer (FRP) composites. The sensor principles are simple and therefore, practical for detec-tion of cracks, debonding and deformation measurements. Structural monitoring capability of the sensor     

Optimising a general repair kit problem with a service constraint

Field services are a particular type of after-sales service performed at the customer’s location where technicians repair malfunctioning machines. The inventory decisions about which spare part types to take to the repair site and in what quantities is called the repair kit problem. This problem is characterized by an order-based performance measure since a customer is only satisfied when all required spare parts are available to fix the machine. As a result, the service level in the decision making process is defined as a job fill rate. In this paper we derive a closed-form expression for the expected service level and total costs for the repair kit problem in a general setting, where multiple units of each part type can be used in a multi-period problem. Such an all-or-nothing strategy is a new characteristic to investigate, but commonly used in practice. Namely, items are only taken from the inventory when all items to perform the repair are available in the right quantity. We develop a new algorithm to determine the contents of the repair kit both for a service and cost model while incorporating this new expression for the job fill rate. We show that the algorithm finds solutions which differ on average 0.2% from optimal costs. We perform a case study to test the performance of the algorithm in practice. Our approach results in service level improvements of more than 30% against similar holding costs.     

计及预防维修时间的一个故障维修模型

本文研究了单部件一个修理工组成的可修系统，为延长其使用寿命，在故障前考虑了预防维修，且假定预防维修能“修复如新”，而故障维修为“修复非新”时，利用几何过程，以系统２次数Ｎ为更换策略，选择最优的Ｎ，使得系统经长期运行单位时间的期望费用最小，最后，还对预防维修的定长间隔时间及更换策略进行了讨论。     

Generation,Spectroscopic Characterization by EPR,and Decay of a Pyranine‐Derived Radical

The pyraninoxyl radical is readily formed from the MnO₂‐promoted oxidation of pyranine. The free radical can be formed in high concentrations (mM ), and presents a characteristic EPR spectrum that indicates a high spin‐density delocalization. It is relatively stable under nitrogen (half‐life ca. 50 min) but readily decays in presence of O₂. In spite of its high stability, the radical readily reacts with antioxidants (phenols and ascorbic acid) with a partial recovery of the parent pyranine. High concentrations of the pyraninoxyl radical (ca. 9 μM ) are present when pyranine is exposed to a free radical source (10 mM 2,2′‐azobis[2‐amidinopropane], 37°). The fact that these radicals readily react with antioxidants (ascorbic acid and caffeic acid) supports the proposal that protection by antioxidants of peroxyl radical‐promoted pyranine bleaching is mainly due to the occurrence of a repair mechanism.     

A model for maintenance service contract design,negotiation and optimization

A model is presented in this paper for maintenance service contract design, negotiation and optimization. The model was developed under the assumption that there are one customer and one unique service provider who is the Original Equipment Manufacturer (OEM) and is called the agent in this paper. This is typically applied to the situation where the OEM is the only possible service supplier such as in the case of major military equipment in the defense sector. Three contract options were considered, depending on the extent of outsourced maintenance activities. From an agent point of view, they are, (1), the agent carries out all repairs and inspections; (2), the agent carries out failure based repairs, and (3), the agent does inspections and repairs to the defects identified at inspections. For options two and three, the customer does the rest of maintenance. The relationship between inspections and failures was modeled using the delay time concept and a numerical example was illustrated. The cases of perfect information to both parties and information asymmetry were also discussed in the example. The model developed can be used for contract design, negotiation and optimization.