Synthesis and Electrospray Ionization Mass Spectra of N-（1,3, 2-Dioxaphosphorinan-2-ylmethyl）thiophosphoramidates

N-（1,3,2-Dioxaphosphorinan-2-ylmethyl）thiophosphoramidates were synthesized and determined by NMR spectra and positive ion electrospray ionization mass spectrometry （ESI-MS） in conjunction with tandem mass spectrometry （MS/MS）. The fragmentation pathways were investigated. The results show that these characteristic ions in ESI mass spectra are useful in the structural determination of N-（1,3,2-dioxaphosphorinan-2-ylmethyl）- thiophosphoramidates.     

Synthesis and Novel Properties of Alkyl Thiophosphoramidate Derivatives of Nucleosides

Ｉｎｔｒｕｄｕｃｔｉｏｎ　　Ｔｈｅｄｅｖｅｌｏｐｍｅｎｔｏｆｎｕｃｌｅｏｓｉｄｅｐｒｏｄｒｕｇｓｃａｐａｂｌｅｏｆｕｎｄｅｒｇｏｉｎｇｉｎｔｒａｃｅｌｌｕｌａｒａｃｔｉｖａｔｉｏｎｔｏｔｈｅｃｏｒｒｅｓｐｏｎｄｉｎｇｎｕｃｌｅｏｔｉｄｅｈａｓｂｅｃｏｍｅａｎａｒｅａｏｆｉｎｔｅｎｓｅｉｎｔｅｒｅｓｔ.1Ｓｅｖｅｒ ａｌｐｕｒｉｎｅａｎｄｐｙｒｉｍｉｄｉｎｅｂａｓｅｓａｎｄｎｕｃｌｅｏｓｉｄｅａｎａｌｏｇｓａｒｅｉｍｐｏｒｔａｎｔｗｅａｐｏｎｓｉｎｔｈｅａｎｔｉｃａｎｃｅｒａｎｄａｎｔｉｖｉｒａｌｃ…     

Studies on Synthesis and Intramolecular Catalyzed Hydrolysis of Thiophosphoramidate Derivatives of Nucleoside

ＩｎｔｒｏｄｕｃｔｉｏｎＮｕｃｌｅｏｓｉｄｅｓａｎｄｔｈｅｉｒａｎａｌｏｇｕｅｓａｓｐｏｔｅｎｔｉａｌａｎｔｉ ｃａｎｃｅｒａｎｄａｎｔｉｖｉｒｕｓａｇｅｎｔｓｈａｖｅｂｅｅｎｓｔｕｄｉｅｄｅｘｔｅｎｓｉｖｅｌｙ .Ｍｏｓｔｏｆｔｈｅｃｕｒｒｅｎｔｌｙｌｉｃｅｎｓｅｄａｎｔｉｖｉｒａｌｄｒｕｇｓａｎｄｍａｎｙｏｆｔｈｅｄｒｕｇｓｕｓｅｄｉｎａｎｔｉｃａｎｃｅｒｃｈｅｍｏｔｈｅｒａｐｙａｒｅｎｕｃｌｅｏｓｉｄｅａｎａｌｏｇｕｅｓ .1Ｆｏｒｔｈｅｍａｊｏｒｉｔｙｏｆｔｈｅｓｅａｎａｌｏｇｕｅｓｓｈｏｗｎ…     

Crystal and Molecular Structure of N－Isopropyl－O－（p－Chlorophenyl）－O＇－（1，2：3，4－Di－O＂－isopropylidene－α－D－galactopyranosyl） Thiophosphoramidate

ＣｒｙｓｔａｌａｎｄＭｏｌｅｃｕｌａｒＳｔｒｕｃｔｕｒｅｏｆＮ－Ｉｓｏｐｒｏｐｙｌ－Ｏ－（ｐ－Ｃｈｌｏｒｏｐｈｅｎｙｌ）－Ｏ＇－（１，２：３，４－Ｄｉ－Ｏ＂－ｉｓｏｐｒｏｐｙｌｉｄｅｎｅ－α－Ｄ－ｇａｌａｃｔｏｐｙｒａｎｏｓｙｌ）Ｔｈｉｏｐｈｏｓｐｈ...     

Synthesis and Novel Properties of Alkyl Thiphosporamidate Derivatives of Nucleosides

Novel alkyl thiophosphoramidate derivatives of nucleosde analogues(5) have been prepared by phosphochloridothioate chemistry.O-Isopropyl 2‘,3‘-O-isopropylidene uridine-5‘-yl N-thiophosphoryl threonine and serine methyl esters(5a and 5b )underwent the intramolecular catalyzed hydrolysis reaction.