| Studies on Synthesis and Intramolecular Catalyzed Hydrolysis of Thiophosphoramidate Derivatives of Nucleoside |
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| 作者姓名： | 苗志伟 付华 冯玉萍 韩波 涂光忠 赵玉芬 |
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| 作者单位： | MIAO，Zhi-Wei a FU，Hua a FENG，Yu-Ping a HAN，Bo a TU，Guang-Zhong b ZHAO，Yu-Fen，a a Key Laboratory of Bioorganic Phosphorus Chemistry，Ministry of Education，Department of Chemistry，School of Life Sciences and Engineering |
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| 基金项目： | theNationalNaturalScienceFoundationofChina (Nos .2 990 2 0 0 3and 39870 415 ) ,theMinistryofScienceandTechnology ,theEducationMinistryofChinaandDoctorCandidateInnovationFoundationinTsinghuaUniversity (No .0 92 430 30 5 ) |
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| 摘 要： | ＩｎｔｒｏｄｕｃｔｉｏｎＮｕｃｌｅｏｓｉｄｅｓａｎｄｔｈｅｉｒａｎａｌｏｇｕｅｓａｓｐｏｔｅｎｔｉａｌａｎｔｉ ｃａｎｃｅｒａｎｄａｎｔｉｖｉｒｕｓａｇｅｎｔｓｈａｖｅｂｅｅｎｓｔｕｄｉｅｄｅｘｔｅｎｓｉｖｅｌｙ .Ｍｏｓｔｏｆｔｈｅｃｕｒｒｅｎｔｌｙｌｉｃｅｎｓｅｄａｎｔｉｖｉｒａｌｄｒｕｇｓａｎｄｍａｎｙｏｆｔｈｅｄｒｕｇｓｕｓｅｄｉｎａｎｔｉｃａｎｃｅｒｃｈｅｍｏｔｈｅｒａｐｙａｒｅｎｕｃｌｅｏｓｉｄｅａｎａｌｏｇｕｅｓ .1Ｆｏｒｔｈｅｍａｊｏｒｉｔｙｏｆｔｈｅｓｅａｎａｌｏｇｕｅｓｓｈｏｗｎ…
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Studies on Synthesis and Intramolecular Catalyzed Hydrolysis of Thiophosphoramidate Derivatives of Nucleoside |
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| MIAO,Zhi-Wei a FU,Hua a FENG,Yu-Ping a HAN,Bo a TU,Guang-Zhong b ZHAO,Yu-Fen,a a Key Laboratory of Bioorganic Phosphorus Chemistry,Ministry of Education.Studies on Synthesis and Intramolecular Catalyzed Hydrolysis of Thiophosphoramidate Derivatives of Nucleoside[J].Chinese Journal of Chemistry,2002,20(11):1434-1438. |
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| Authors: | MIAO Zhi-Wei a FU Hua a FENG Yu-Ping a HAN Bo a TU Guang-Zhong b ZHAO Yu-Fen a a Key Laboratory of Bioorganic Phosphorus Chemistry Ministry of Education |
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| Institution: | MIAO,Zhi-Wei a FU,Hua a FENG,Yu-Ping a HAN,Bo a TU,Guang-Zhong b ZHAO,Yu-Fen,a a Key Laboratory of Bioorganic Phosphorus Chemistry,Ministry of Education,Department of Chemistry,School of Life Sciences and Engineering |
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| Abstract: | Novel thiophosphoramidate derivatives of nucleoside analogue as membrane‐soluble prodrugs of the bioactive free nucleotides have been prepared by thiophosphorylation reaction. 2′,3′‐O, O′‐Isopropylidene uridine‐5′‐yl N‐thiophosphoryl serine and threonine methyl esters underwent the intramolecular catalyzed hydrolysis reaction. |
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| Keywords: | synthesis thiophosphoramidate nucleoside analogue hydrolysis reaction mechanism |
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