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排序方式: 共有103条查询结果,搜索用时 77 毫秒
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Gun'ko V. M. Mikhalovskii S. V. Melillo M. Voronin E. F. Nosach L. V. Pakhlov E. M. 《Theoretical and Experimental Chemistry》2004,40(3):137-143
The interaction of ibuprofen [2-(4-isobutylphenyl)propionic acid] with the surface of carbon and oxide adsorbents was investigated. The significant role of wide pores during the adsorption of ibuprofen on carbon adsorbents in the presence of protein molecules was demonstrated. At low concentrations ibuprofen is adsorbed on the surface of hydrophilic and hydrophobic adsorbents in the form of a monomer, but the contribution from the adsorbed dimer increases with increase in its concentration. 相似文献
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TERESA HŁADOŃ JAN Pawlaczyk BARBARA Szafran 《Journal of inclusion phenomena and macrocyclic chemistry》2000,36(1):1-8
The ibuprofen--cyclodextrin inclusion complex was prepared by theco-precipitation method. The identity of the obtained product was verified by X-ray and thermogravimetric techniques. The effect of -cyclodextrin on the stability of ibuprofen was analysed. 相似文献
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固定化酶不对称合成(S)+—(+)—布洛芬的研究 总被引:3,自引:0,他引:3
能够不对称水解布洛芬乙酯的酵母菌T158固定化在壳聚糖珠中,固定化酵母菌的活力回收达60%,最适温度为45℃,半衰期为75d以上。 相似文献
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The enantiomeric resolution of (+/-)-ibuprofen into its enantiomers was achieved by TLC on silica gel plate using optically pure (-)-brucine as a chiral selector and acetonitrile-methanol (5:1, v/v) as the solvent system. Spots were located in an iodine chamber. The detection limit was 4.9 microg. The effect of concentration of the chiral selector, temperature and pH on resolution has been studied. 相似文献
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In recent years, nanomaterial-based drug delivery carriers have become some of the most attractive to be studied. The purpose of this study is to investigate the interaction of C60 fullerene, carbon nanotube and graphene having porphyrin-like FeN4 clusters with a non-steroidal anti-inflammatory drug (ibuprofen) by means of the density functional theory. Results showed that the graphene with FeN4 clusters could remarkably increase the tendency of graphene for adsorption of ibuprofen drug. Also, our ultraviolet–visible results show that the electronic spectra of the complexes exhibit a blue shift toward lower wavelengths (higher energies). It was found that Ibp/FeN4-graphene had high chemical reactivity, which was important for binding of the drug onto the target site. In order to go further and gain insight into the binding features of considered systems with ibuprofen drug, the Atoms in Molecules analysis was performed. Our results determine the electrostatic features of the Ibp/FeN4-graphene bonding. Consequently, the results demonstrated that the FeN4-graphene could be used as potential carriers for the delivery of ibuprofen drug. 相似文献
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Facile synthesis of novel ibuprofen bearing polyurethane 1 has been achieved for the first time and found to display the release pattern of ibuprofen based on the easy cleavage of ester linkages. Thorough characterizations (FT‐IR, UV‐Vis, NMR, and elemental analysis) were performed to ascertain the structure of polyurethane 1. 相似文献
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Abstract A novel drug-polysaccharide conjugate with konjac glucomannan (KGM) as a drug carrier was fabricated through the esterification of ibuprofen (IBU), an anti-inflammatory drug, with KGM. The influences of the reaction conditions, such as the amount of ibuprofen acryl chloride, reaction time, reaction temperature, and the amount of catalyst, on the degree of substitution were investigated. KGM ibuprofen ester (KGM-IBU) was characterized by Fourier transform infrared spectrometry (FTIR), X-ray diffraction (XRD), solid-state 13C NMR, scanning electron microscopy (SEM), transmission electron microscopy (TEM), thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), and dynamic mechanical analysis (DMA). The hydrophobic structure of IBU in KGM-IBU was proven by the fluorescence emission spectra of pyrene. In addition, by using commercially available ibuprofen sustained-release capsules (IBU-SRC) as a control, the in vitro controlled release performance of KGM-IBU was evaluated. The cumulative release of IBU-SRC within 36?h was 94%, while that of KGM-IBU within 36?h was 77%. The results showed that KGM-IBU had better sustained-release performance without a burst release effect. The obtained products could be used as a potential biocompatible sustained-release drug delivery system. 相似文献
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