| 毛细管区带电泳法快速测定复方布洛芬片的有效成分 |
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| 引用本文： | 陈恒武,黄棣华,陈青俊,李会林.毛细管区带电泳法快速测定复方布洛芬片的有效成分[J].色谱,1998(4). |
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| 作者姓名： | 陈恒武 黄棣华 陈青俊 李会林 |
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| 作者单位： | 杭州大学化学系(陈恒武)，浙江医科大学(黄棣华)，浙江省食品质量监督检验站(陈青俊)，浙江省药品检验所(李会林) |
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| 摘 要： | 研究了用毛细管区带电泳法快速测定复方布洛芬片中布洛芬和伪麻黄碱含量的方法。在０．０２５ｍｏｌ／Ｌ的磷酸盐缓冲液（ｐＨ８．１）中，上述两组分可在３ｍｉｎ内得以完全分离，用紫外检测器在２１０ｎｍ处检测，并以外标法定量。１１次测定含有９．５ｍｇ／Ｌ盐酸伪麻黄碱和６６．７ｍｇ／Ｌ布洛芬的试样溶液，相对标准偏差为２．９％（伪麻黄碱）和１．９％（布洛芬），回收率为１０３．１％（伪麻黄碱）和９７．６％（布洛芬）。应用毛细管区带电泳法测定复方布洛芬片剂的含量，所得结果与ＨＰＬＣ法一致。
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| 关 键 词： | 毛细管区带电泳，布洛芬，伪麻黄碱，复方布洛芬片，定量分析 |
Rapid Determination of Active Constituents in Compound Ibuprofen Tablets by Capillary Zone Electrophoresis |
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| Chen Hengwu a,Huang Dihua b,Chen Qingjun c and Li Huilin d.Rapid Determination of Active Constituents in Compound Ibuprofen Tablets by Capillary Zone Electrophoresis[J].Chinese Journal of Chromatography,1998(4). |
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| Authors: | Chen Hengwu a Huang Dihua b Chen Qingjun c and Li Huilin d |
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| Abstract: | A rapid capillary zone electrophoresis (CZE) method for the determination of ibuprofen and pseudoephedrine hydrochloride in compound ibuprofen tablets has been developed. CZE was performed in 0.025 mol/L phosphate buffer solution (pH 8.1). The two compounds were completely separated within 3 minutes, and quantified with a UV detector at 210nm by means of external standard method. Relative standard deviations of 2.9% for pseudoephedrine hydrochloride and 1.9% for ibuprofen were achieved for 11 determinations of the sample solution containing 9.5mg/L pseudoephedrine hydrochloride and 66.7mg/L ibuprofen, and recoveris of 103.1% and 97.6% were obtained respectively for the spiked pseudoephedrine hydrochloride and ibuprofen. The proposed method has been applied for the analysis of compound ibuprofen tablets, and the analytical results are in good agreement with those obtained by HPLC method. |
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| Keywords: | capillary zone eletrophoresis ibuprofen pseudoephedrine compound ibuprofen tablet quanitative analysis |
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