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排序方式: 共有1770条查询结果,搜索用时 15 毫秒
1.
Amano Yuki Ishikawa Satoshi Yoshitake Tatsuhiro Kondou Takahiro 《Nonlinear dynamics》2021,104(3):1917-1935
Nonlinear Dynamics - Rectangular flat-bottom liquid tanks known as tuned liquid dampers (TLDs) are often used as passive mechanical dampers. Sloped- and triangular-bottom TLDs have been reported to... 相似文献
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Optical Review - This paper demonstrates a method to estimate the depth of a fluorescence object in turbid media using dual-wavelength excited photodynamic diagnosis, to aid in the invasion depth... 相似文献
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Kentarou Sakamoto Dr. Misao Akishiba Takahiro Iwata Dr. Kazuya Murata Dr. Seiya Mizuno Dr. Kenichi Kawano Dr. Miki Imanishi Prof. Dr. Fumihiro Sugiyama Prof. Dr. Shiroh Futaki 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2020,132(45):20165-20173
Endocytic pathways are practical routes for the intracellular delivery of biomacromolecules. Along with this, effective strategies for endosomal cargo release into the cytosol are desired to achieve successful delivery. Focusing on compositional differences between the cell and endosomal membranes and the pH decrease within endosomes, we designed the lipid-sensitive and pH-responsive endosome-lytic peptide HAad. This peptide contains aminoadipic acid (Aad) residues, which serve as a safety catch for preferential permeabilization of endosomal membranes over cell membranes, and His-to-Ala substitutions enhance the endosomolytic activity. The ability of HAad to destabilize endosomal membranes was supported by model studies using large unilamellar vesicles (LUVs) and by increased intracellular delivery of biomacromolecules (including antibodies) into live cells. Cerebral ventricle injection of Cre recombinase with HAad led to Cre/loxP recombination in a mouse model, thus demonstrating potential applicability of HAad in vivo. 相似文献
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Chin-Soon Phan Takashi Kamada Takahiro Ishii Toshiyuki Hamada 《Natural product research》2019,33(6):808-813
One new compound, 12-epi-9-deacetoxyxenicin (1) along with a hydroperoxide product, 12-epi-9-deacetoxy-8-hydroperoxyxenicin (2) and two known sesquiterpenoids (3–4) were isolated from a population of Bornean soft coral Xenia sp. The structures of these secondary metabolites were elucidated based on their spectroscopic data. Compounds 1 and 2 showed cytotoxic activity against ATL cell line, S1T. In addition, compound 3 exhibited hyphal inhibition of Lagenidium thermophilum. 相似文献
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Takahiro Moriyama Daiki Mizukami Dr. Makoto Yoritate Dr. Kazuteru Usui Dr. Daisuke Takahashi Dr. Eisuke Ota Prof. Dr. Mikiko Sodeoka Prof. Dr. Tadashi Ueda Prof. Dr. Satoru Karasawa Prof. Dr. Go Hirai 《Chemistry (Weinheim an der Bergstrasse, Germany)》2022,28(11):e202103925
Minimalist photo-reactive probes, which consist of a photo-reactive group and a tag for detection of target proteins, are useful tools in chemical biology. Although several diazirine-based and aryl azide-based minimalist probes are available, no keto-based minimalist probe has yet been reported. Here we describe minimalist probes based on a 2-thienyl-substituted α-ketoamide bearing an alkyne group on the thiophene ring. The 3-alkyne probe showed the highest photo-affinity labeling efficiency. 相似文献
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We develop the exact WKB analysis of an M2P1T (merging two simple poles and one simple turning point) Schrödinger equation. In Part II, using a WKB-theoretic transformation to the algebraic Mathieu equation constructed in Part I, we calculate the alien derivative of its Borel transformed WKB solutions at each fixed singular point relevant to the simple poles through the analysis of Borel transformed WKB solutions of the Legendre equations. In the course of the calculation of the alien derivative we make full use of microdifferential operators whose symbols are given by the infinite series that appear in the coefficients of the algebraic Mathieu equation and the Legendre equation. 相似文献
10.
Yumiko Ohtsuka Prof. Takahiro Seki Prof. Yukikazu Takeoka 《Angewandte Chemie (International ed. in English)》2015,54(51):15368-15373
We report the preparation of thermally tunable hydrogels displaying angle‐independent structural colors. The porous structures were formed with short‐range order using colloidal amorphous array templates and a small amount of carbon black (CB). The resultant porous hydrogels prepared using colloidal amorphous arrays without CB appeared white, whereas the hydrogels with CB revealed bright structural colors. The brightly colored hydrogels rapidly changed hues in a reversible manner, and the hues varied widely depending on the water temperature. Moreover, the structural colors were angle‐independent under diffusive lighting because of the isotropic nanostructure generated from the colloidal amorphous arrays. 相似文献