Comparative biological study between quinazolinyl–triazinyl semicarbazide and thiosemicarbazide hybrid derivatives

Molecular Diversity - Practical synthesis and biological activities of quinazolinyl–triazinyl semicarbazides (10a–j) and quinazolinyl–triazinyl thiosemicarbazides (11a–j)...     

Palladium-catalyzed [5+2] oxidative annulation of N-Arylhydrazones with alkynes through CH activation to synthesize Benzo[d][1,2]diazepines

An efficient and novel method using palladium catalyst for the synthesis of benzo[d][1,2]diazepines by [5 + 2] annulation of N-arylhydrazones with alkynes has been developed. This methodology undergoes through eight membered palladacycle serving as a backbone for the formation of CC/CN bond to provide benzodiazepine derivatives in moderate to good yield.     

Palladium catalyzed annulation of benzylamines and arynes via C–H activation to construct 5,6-dihydrophenanthridine derivatives

An efficient and versatile strategy employing palladium catalyst to synthesize 5,6-dihydrophenanthridine derivatives by annulation of benzylamines and arynes through C–H activation has been reported. This is promising one pot methodology which includes the use of Kobayashi's aryne precursor to construct plethora of 5,6-dihydrophenanthridine derivatives in moderate to good yield.