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Mahdieh Darroudi Sara Ranjbar Mohammad Esfandiar Mahsima Khoshneviszadeh Mahshid Hamzehloueian Mehdi Khoshneviszadeh Yaghoub Sarrafi 《应用有机金属化学》2020,34(12):e5962
In the present work, novel 5-((1-benzyl-1,2,3-triazol-4-yl)methoxybenzylidene)-2-(arylamino)thiazol-4-one thiazolone incorporated triazole derivatives have been designed as tyrosinase inhibitors. The compounds were synthesized through click reaction in good yield. Moreover, the antityrosinas activity of the synthesized derivatives was evaluated. In the search for establishing a click copper-catalyzed azide/alkyne cycloaddition (CuAAC) reaction under strict conditions, in terms of a novel air-stable, a recyclable and efficient magnetic catalyst was planned for new triazole derivatives as a well-organized copper iodide supported on the functionalized Fe3O4@SiO2 core-shell (CuI/Fe3O4@SiO2(TMS-EDTA) nanoparticles). The engineered nanocatalyst synthesized for the first time and characterized by different methods, including FT-IR spectroscopy, XRD, FESEM, EDX, TEM, TGA, and BET analysis. The excellent catalytic performance in ethanol with high surface area (351.7 m2g−1) and short reaction time for diverse functional groups (120–200 min), no use of toxic solvents, reusability of the catalyst, and using eco-friendly conditions are the advantageous of this work. Moreover,the nanocatalyst can be used at least five times without any significant decrease in the yield of the reaction. The thiazolidine-triazole derivatives 9a , 9c , 9e , and 9 g showed promising tyrosinase inhibitory activity with IC50 values in the range of 5.90–9.81 μM. The compounds were found to be considerably more potent tyrosinase inhibitors than the reference inhibitor kojic acid (IC50 = 18.36 μM). 相似文献
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Tahmineh Akbarzadeh Saeedeh Noushini Somayeh Taban Mohammad Mahdavi Mahsima Khoshneviszadeh Mina Saeedi Saeed Emami Mohammad Eghtedari Yaghoub Sarrafi Mehdi Khoshneviszadeh Maliheh Safavi Kouros Divsalar Mohammad Hassan Moshafi Ali Asadipour Reyhaneh Sabourian Najmeh Edraki Omidreza Firouzi Ramin Miri Abbas Shafiee Alireza Foroumadi 《Molecular diversity》2015,19(2):273-281
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Karimian Somaye Ranjbar Sara Dadfar Mahsa Khoshneviszadeh Mahsima Gholampour Maryam Sakhteman Amirhossein Khoshneviszadeh Mehdi 《Molecular diversity》2021,25(4):2339-2349
Molecular Diversity - A series of ethyl 2-amino-4H-benzo[h]chromene-3-carboxylate derivatives, having phenyl ring with diverse substituents at C4 position of 4H-benzochromene nucleus, were... 相似文献
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