Diversity-oriented synthesis and antifungal activities of novel pimprinine derivative bearing a 1,3,4-oxadiazole-5-thioether moiety

Molecular Diversity - Based on the strategy of diversity-oriented synthesis and the structures of natural product pimprinine and streptochlorin, two series of novel pimprinine derivatives...     

Influence of flexible solar arrays on vibration isolation platform of control moment gyroscopes

A high-performance vibration isolation platform (VIP) has been developed for a cluster of control moment gyroscopes (CMGs). CMGs have long been used for satellite attitude control. In this paper, the influence of flexible solar arrays on a passive multi-strut VIP of CMGs for a satellite is analyzed. The reasonable parameters design of flexible solar arrays is discussed. Firstly, the dynamic model of the integrated satellite with flexible solar arrays, the VIP and CMGs is conducted by Newton-Euler method. Then based on reasonable assumptions, the transmissibility matrix of the VIP is derived. Secondly, the influences of the flexible solar arrays on both the performance of the VIP and the stability of closed-loop control systems are analyzed in detail. The parameter design limitation of these solar arrays is discussed. At last, by selecting reasonable parameters for both the VIP and flexible solar arrays, the attitude stabilization performance with vibration isolation system is predicted via simulation.     

Detection of catecholamine metabolites in urine based on ultra-high-performance liquid chromatography–tandem mass spectrometry

The excretion of neurotransmitter metabolites in normal individuals is of great significance for health monitoring. A rapid quantitative method was developed with ultra-performance liquid chromatography–tandem mass spectrometry. The method was further applied to determine catecholamine metabolites vanilymandelic acid (VMA), methoxy hydroxyphenyl glycol (MHPG), dihydroxy-phenyl acetic acid (DOPAC), and homovanillic acid (HVA) in the urine. The urine was collected from six healthy volunteers (20–22 years old) for 10 consecutive days. It was precolumn derivatized with dansyl chloride. Subsequently, the sample was analyzed using triple quadrupole mass spectrometry with an electrospray ion in positive and multireaction monitoring modes. The method was sensitive and repeatable with the recoveries 92.7–104.30%, limits of detection (LODs) 0.01–0.05 μg/mL, and coefficients no less than 0.9938. The excretion content of four target compounds in random urine samples was 0.20 ± 0.086 μg/mL (MHPG), 1.27 ± 1.24 μg/mL (VMA), 3.29 ± 1.36 μg/mL (HVA), and 1.13 ± 1.07 μg/mL (DOPAC). In the urine, the content of VMA, the metabolite of norepinephrine and adrenaline, was more than MHPG, and the content of HVA, the metabolite of dopamine, was more than DOPAC. This paper detected the levels of catecholamine metabolites and summarized the characteristics of excretion using random urine samples, which could provide valuable information for clinical practice.     

A new organically-templated cobalt borophosphate with a novel borophosphatic anionic partial structure

A novel cobalt borophosphate, (NH₄)₂(C₄H₁₂N₂)[Co₂B₄P₆O₂₄(OH)₂]·H₂O with the mixed cations has been synthesized under mild hydrothermal conditions. Its crystal structure was determined by the single-crystal X-ray diffraction (tetragonal, I4₁/a (no. 88), a=14.207(3) Å, c=24.956(6) Å, V=5037.09(2) Å³, Z=8). The crystal structure consists of a new type of three-dimensional borophosphatic anionic partial framework, which is built from the condensation of the fundamental building unit (FBU) [B₂P₃O₁₄(OH)]. The CoO₆ octahedra are enchased in such borophosphate network to form a complex open framework with a three-dimensional intersecting channel system, the voids of which are occupied by ammonium, dipronated piperazine ions and water molecules, respectively. The magnetic measurement of the title compound has also been investigated.     

New bactericide derived from Isatin for treating oilfield reinjection water

ABSTRACT: Isatin, an extract from Strobilanthes cusia (Nees) Kuntze, was the base for synthesizing derivatives that were screened for antibacterial activity against oilfield water-borne bacteria. The bacterial groups are sulfate reducing, iron and total. The derivatives were characterized by spectrums and they showed good to moderate activity against sulfate reducing bacteria.     

Error analysis and a new steering law design for spacecraft control system using SGCMGs

Based on the singular value decomposition theory,this paper analyzed the mechanism of escaping/avoiding singularity using generalized and weighted singularity-robust steering laws for a spacecraft that uses single gimbal control moment gyros (SGCMGs) as the actuator for the attitude control system.The expression of output-torque error is given at the point of singularity,proving the incompatible relationship between the gimbal rate and the output-torque error.The method of establishing a balance between the gimbal rate and the output-torque error is discussed,and a new steering law is designed.Simulation results show that the proposed steering law can effectively drive SGCMGs to escape away from singularities.     

基于刻蚀策略的多孔氧化铜的合成及其在葡萄糖电化学传感中的应用

采用单宁酸对铜金属有机骨架材料蚀刻的策略,制备得到一种疏松多孔的CuO（记为E-CuO）,并将E-CuO修饰在玻碳电极上（E-CuO/GCE）用于葡萄糖的电化学传感研究。结果表明：在0.25~2 000 μmol·L^-1葡萄糖浓度范围内,E-CuO/GCE具有0.273 μA·μL·mol^-1·cm^-2的较高灵敏度及良好的抗干扰性能、重现性和稳定性。在实际样品分析中,E-CuO/GCE在蜂蜜和水果糖的加标回收率实验中表现良好,可用于葡萄糖注射液中葡萄糖的直接测定。     

米托蒽醌分子印迹传感器的研究及其应用

在弱酸性条件下, 以邻氨基酚为单体交联剂, 米托蒽醌为模板分子, 用循环伏安法电聚合成米托蒽醌分子印迹聚邻氨基酚敏感膜传感器. 该传感器对米托蒽醌具有良好的选择性和敏感度, 米托蒽醌浓度分别在3.3×10-7~1.0×10-5 mol/L及1.0×10-5~5.0×10-5 mol/L范围内与峰电流减小量呈线性关系, 检测下限为1.6×10-7 mol/L, 同时对分子印迹膜的结构和性能进行了研究.     

米托蒽醌在金电极上的电化学研究及其应用

米托蒽醌(MTX)在0.2 mol/L B-R缓冲溶液(pH=1.5)中循环伏安扫描时,在金电极上会产生一个灵敏的氧化峰P1(峰电位为1.087 V)和两个灵敏的还原峰P2(峰电位为0.817 V)、P3(峰电位为0.764 V)。P1峰电流值与MTX浓度在1.0×10-9~1.0×10-6mol/L范围内呈良好的线性关系;其检出限可达5.6×10-10mol/L。本研究优化了测定米托蒽醌的最佳实验条件,建立了可灵敏测定米托蒽醌的新方法;同时对米托蒽醌在金电极上的电化学行为进行了较为详细的研究。     

改进的全矢量有效折射率方法分析光子晶体光纤的色散特性

得到了全矢量有效折射率方法中归一化等效纤芯半径(p/Λ)随归一化空气孔直径(d/Λ)和归一化频率(Λ/λ)的变化关系，修正了p/Λ为固定值的不合理取法，得到了改进的全矢量有效折射率方法(IFVEIM).用IFVEIM计算的基模有效折射率和总色散等模式特性与多极法的结果和试验值相比较都具有很好的一致性，将基模有效折射率的误差减小了2—3个数量级.用IFVEIM详细地分析了光子晶体光纤的色散特性，得到了色散值、波长、孔间距、d/Λ之间的相互变化关系. 关键词： 光子晶体光纤 有效折射率方法 等效纤芯半径 色散