Identification of pyrrolo-pyridine derivatives as novel class of antibacterials

Molecular Diversity - A series of 5-oxo-4H-pyrrolo[3,2-b]pyridine derivatives was identified as novel class of highly potent antibacterial agents during an extensive large-scale high-throughput...     

Formation, cascade development, and rupture of the X-pinch neck

Data from high-resolution x-ray shadow photography of an X-pinch in the diode of a high-power dense-plasma generator are presented. The processes leading to the formation of a minidiode, the compression of the neck arising in it, and the cutoff and subsequent emptying of the neck are studied. Cascade formation of short-lived structures, which consistently reproduce the form of the minidiode on small scales before the x-ray burst, is observed in the course of the implosion. The position of the x-ray emission points is determined.     

Determination of the Efficient Number of Interferefnce Sources in the Problem of Adaptive Estimation of Temporal Waveforms of Narrow-Band Signals Using Antenna Arrays

Radiophysics and Quantum Electronics - We consider the problem of estimating temporal waveforms of the signals, which are generated by a spatially distributed set of sources, by using antenna...     

Electrons in a Nonideal Partially Degenerated Plasma with Multiple Ionization

We consider peculiarities in the behavior of free electrons in an extremely-dense hot plasma with multiple ionization and partial degeneration. In different ways, we exhibit the strong Coulomb coupling of electrons and ions in the behavior of low- and high-kinetic-energy electrons. As a result, a necessity arises to consider, along with classical fast Debye electrons, their complementary cellular group of electrons constantly interacting with central ions of cells. We discuss the distribution of free electrons between the two groups, along with the role of two-group effects, of a not point character of ions in electron-transfer processes, and the consequences of the X-ray emitting X-pinch hot spot for the plasma. The existence of the physical limits for X-pinch plasma compression is among those consequences.     

Estimation of the background noise level with a horizontal array against spatially uncorrelated and structural interferences

A method of estimating the isotropic sea noise level with a horizontal array in the presence of uncorrelated interference and interference with a complex spatial structure is proposed and experimentally tested. The algorithm is based on the approximation of the Capon spatial spectrum of the received signal using a model Capon spectrum for the sum of isotropic noise and uncorrelated interference. A numerical simulation is carried out to study the dependence of the accuracy of the proposed method on the interference intensity, the distance from the array to the sources of structural interference, and the number of structural interference sources. It is shown that the use of the Capon spectrum provides a strong suppression of an intense structural interference source positioned near the array. The efficiency of the proposed method is confirmed experimentally.     

New ASGPR-targeted ligands based on glycoconjugated natural triterpenoids

Russian Chemical Bulletin - New ligands for targeted delivery to the liver based on glycoconjugated natural triterpenoids are proposed. Simple chemical transformations of starting lupane...     

Dynamics of thin exploded-wire plasma with a cold dense core

Ideas are put forward regarding the possibility of a cold dense core, surrounded by a plasma corona, forming near the axis at the initial stage of a nanosecond electric explosion of metal wires, and the influence of such a radial structure on the plasma compression dynamics is discussed. Experimental evidence supporting these suppositions is presented. It includes both indirect confirmations, based on optical and x-ray diagnostics data, and direct observations of the core by new means of x-ray probing employing an X pinch as a source of radiation. Zh. éksp. Teor. Fiz. 114, 1215–1229 (October 1998)     

Time-resolved X-ray spectroscopy of hot spots in an X-pinch

The plasma parameters in hot spots of an X-pinch are determined by using time-resolved data from X-ray spectroscopy in experiments on the implosion of crossed Ti wires in the XP device with a current of 480 kA and pulse duration of 100 ns. The electron densities and temperatures calculated from these data are in the ranges (0.8–3)×10²³cm^–3 and 1–2.5 keV, respectively. An analysis performed shows that the plasma processes are highly nonequilibrium.