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Cusinato Marco Guercilena Federico Maria Perego Albino Logoteta Domenico Radice David Bernuzzi Sebastiano Ansoldi Stefano 《The European Physical Journal A - Hadrons and Nuclei》2022,58(5):1-69
The European Physical Journal A - PUMA, antiProton Unstable Matter Annihilation, is a nuclear-physics experiment at CERN aiming at probing the surface properties of stable and rare isotopes by use... 相似文献
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Giorgio Facchetti Michael S. Christodoulou Lina Barragn Mendoza Federico Cusinato Lisa Dalla Via Isabella Rimoldi 《Molecules (Basel, Switzerland)》2020,25(23)
The synthesis of a small library of 8-substituted 2-methyl-5,6,7,8-tetrahydroquinoline derivatives is presented. All the compounds were tested for their antiproliferative activity in non-cancer human dermal microvascular endothelial cells (HMEC-1) and cancer cells: human T-lymphocyte cells (CEM), human cervix carcinoma cells (HeLa), human dermal microvascular endothelial cells (HMEC-1), colorectal adenocarcinoma (HT-29), ovarian carcinoma (A2780), and biphasic mesothelioma (MSTO-211H). Compounds 3a, 5a, and 2b, showing significant IC50 values against the whole panel of the selected cells, were further synthesized and tested as pure enantiomers in order to shed light on how their stereochemistry might impact on the related biological effect. The most active compound (R)-5a was able to affect cell cycle phases and to induce mitochondrial membrane depolarization and cellular ROS production in A2780 cells. 相似文献
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