A node formulation for multistage stochastic programs with endogenous uncertainty

Computational Management Science - This paper introduces a node formulation for multistage stochastic programs with endogenous (i.e., decision-dependent) uncertainty. Problems with such structure...     

Nonlinear vibrations and damping of fractional viscoelastic rectangular plates

Nonlinear Dynamics - A new model-free robust control scheme for payload swing angle attenuation of two-dimensional crane systems with varying rope length is introduced in this work. The proposed...     

Synthesis of lupeol derivatives and their antileishmanial and antitrypanosomal activities

The natural product lupeol 1 was isolated from aerial parts of Vernonia scorpioides with satisfactory yield, which made it viable to be used as starting material in semisynthetic approach. Ten lupeol derivatives 2–11 were prepared by classical procedures. Including, five new esters derivatives 7–11, which were obtained by structural modifications in the isopropylidene fragment. All semisynthetic compounds and lupeol 1–11 were confirmed by ¹H NMR, ¹³C NMR and HRMS. Their antiprotozoal activity was evaluated in vitro against L. amazonensis and T. cruzi. Derivative 6 showed the best antitrypanosomal activity (IC₅₀ = 12.48 μg/mL) and the lowest cytotoxic derivative (CC₅₀ = 161.50 μg/mL). The mechanism of action of the most active derivatives (4, 6 and 11) is not dependent from the enzyme trypanothione reductase.     

Asymptotic results for weighted means of linear combinations of independent Poisson random variables

ABSTRACT

In this paper we prove the large deviation principle for a class of weighted means of linear combinations of independent Poisson distributed random variables, which converge weakly to a normal distribution. The interest in these linear combinations is motivated by the diffusion approximation in Lansky [On approximations of Stein's neuronal model, J. Theoret. Biol. 107 (1984), pp. 631–647] of the Stein's neuronal model (see Stein [A theoretical analysis of neuronal variability, Biophys. J. 5 (1965), pp. 173–194]). We also prove an analogue result for sequences of multivariate random variables based on the diffusion approximation in Tamborrino, Sacerdote, and Jacobsen [Weak convergence of marked point processes generated by crossings of multivariate jump processes. Applications to neural network modeling, Phys. D 288 (2014), pp. 45–52]. The weighted means studied in this paper generalize the logarithmic means. We also investigate moderate deviations.     

Host–Guest Chemistry of a Bis‐Calix[4]pyrrole Derivative Containing a trans/cis‐Switchable Azobenzene Unit with Several Aliphatic Bis‐Carboxylates

The azobenzene unit used as a photochemically and thermally switchable linker in the assembly of a bis‐calix[4]pyrrole receptor provides a means to modulate the binding of bis‐carboxylates of significant biological importance in cancer research. Conversely, the complexation of different bis‐anionic guests has significant kinetic effects on both the photochemical and thermal trans/cis isomerization of the azobenzene unit.     

Isolation of Bisphenol A-Tolerating/degrading Shewanella haliotis Strain MH137742 from an Estuarine Environment

Applied Biochemistry and Biotechnology - The human exposure to bisphenol A (BPA) occurs frequently. Once, this compound was one of the highest volume chemicals produced worldwide and used as a...     

Unprecedented Diastereoselective Arylogous Michael Addition of Unactivated Phthalides

The first highly enantioselective arylogous Michael reaction (AMR) of 3-unsubstituted phthalides has been described. This phase-transfer methodology, which uses catalytic amounts of KOH/18-crown-6 catalyst in mesitylene in the presence of N,O-bis(trimethylsilyl)acetamide (BSA), gives access to a broad range of 3-monosubstituted phthalides with high levels of syn diastereoselectivity and good yields, starting from 3-unsubstituted derivatives and diverse α,β-unsaturated carbonyl compounds. The reaction also applies to unactivated 3-alkyl phthalides to afford 3,3-dialkyl derivatives. A plausible mechanism has been suggested. DFT analysis of possible transition states gives a rationale of the high syn diastereoselectivity observed and its correlation with the solvent's dielectric constant.