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1.
Redondo Mara Julia Romn Lucrecia Rossi Bertone Fiorela Verdecchia Melina 《Algebras and Representation Theory》2022,25(4):1037-1059
Algebras and Representation Theory - Let A and B be two Morita equivalent finite dimensional associative algebras over a field . It is well known that Hochschild cohomology is... 相似文献
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Potential of prodendronic polyamines with modulated segmental charge density as novel coating for fast and efficient analysis of peptides and basic proteins by CE and CE‐MS 下载免费PDF全文
Tanize Acunha Clara Ibáñez María Isabel Pascual Reguera Mariagiovanna Sarò Rodrigo Navarro Juan Alfonso Redondo Helmut Reinecke Alberto Gallardo Carolina Simó Alejandro Cifuentes 《Electrophoresis》2015,36(14):1564-1571
In this work, the suitability of a new polymer family has been investigated as capillary coatings for the analysis of peptides and basic proteins by CE. This polymer family has been designed to minimize or completely prevent protein–capillary wall interactions and to modify the EOF. These coating materials are linear polymeric chains bearing as side cationizable moiety a dentronic triamine derived from N,N,N’,N’‐tetraethyldiethylenetriamine (TEDETA), which is linked to the backbone through a spacer (unit labeled as TEDETAMA). Four different polymers have been prepared and evaluated: a homopolymer which comprised only of those cationizable repetitive units of TEDETAMA, and three copolymers that randomly incorporate TEDETAMA together with neutral hydrosoluble units of N‐(2‐hydroxypropyl) methacrylamide (HPMA) at different molar percentages (25:75, 50:50 and 75:25). It has been demonstrated that the composition of the copolymers influences the EOF and therefore the separation of the investigated biopolymers. Among the novel polymers studied, poly‐(TEDETAMA‐co‐HPMA) 50:50 copolymer was successfully applied as coating material of the inner capillary surface in CE‐UV and CE‐MS, providing EOF reversing together with fast and efficient baseline separation of peptides and basic proteins. Finally, the feasibility of the polymer‐coated capillary was shown through the analysis of lysozyme in a cheese sample. 相似文献
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Juan Alfonso Redondo Enrique Martínez‐Campos Laetitia Plet Mnica Prez‐Perrino Rodrigo Navarro Guillermo Corrales Abhay Pandit Helmut Reinecke Alberto Gallardo Jos Luis Lpez‐Lacomba Alfonso Fernndez‐Mayoralas Carlos Elvira 《Macromolecular rapid communications》2016,37(7):575-583
The incorporation of cyclodextrins (CDs) to nonviral cationic polymer vectors is very attractive due to recent studies that report a clear improvement of their cytocompatibility and transfection efficiency. However, a systematic study on the influence of the CD derivatization is still lacking. In this work, the relevance of β‐CD permethylation has been addressed by preparing and evaluating two series of copolymers of the cationic N‐ethyl pyrrolidine methacrylamide (EPA) and styrenic units bearing pendant hydroxylated and permethylated β‐CDs (HCDSt and MeCDSt, respectively). For both cell lines, CDs permethylation shows a strong influence on plasmid DNA complexation, “in vitro” cytocompatibility and transfection efficiency of the resulting copolymers over two murine cell lines. While the incorporation of the hydroxylated CD moiety increased the cytotoxicity of the copolymers in comparison with their homopolycationic counterpart, the permethylated copolymers have shown full cytocompatibility as well as superior transfection efficiency than the controls. This behavior has been related to the different chemical nature of both units and tentatively to a different distribution of units along the polymeric chains. Cellular internalization analysis with fluorescent copolymers supports this behavior.
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An experimental study of mixing across density interfaces produced by laterally heterogenous turbulence is presented in this paper. The turbulence is generated by a flow or air bubles rising through a density interface produced by brine and fresh water. The mixing efficiency, , of the process is measured comparing the increase in potential energy with the available kinetic energy. We find that there is a decrease in the global mixing efficiency of the process with the length of the tank, the shape of (Ri) depends also on the air flow producing the turbulence, showing a geometrical limit to the ammount of kinetic energy which may be used for mixing. 相似文献
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Dedicated to Elliott Lieb on the occasion of his 60th birthday. 相似文献
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Dr. Paula Morales Dr. Gemma Navarro Marc Gómez-Autet Laura Redondo Prof. Dr. Javier Fernández-Ruiz Dr. Laura Pérez-Benito Dr. Arnau Cordomí Prof. Dr. Leonardo Pardo Prof. Dr. Rafael Franco Dr. Nadine Jagerovic 《Chemistry (Weinheim an der Bergstrasse, Germany)》2020,26(68):15839-15842
Single chemical entities with potential to simultaneously interact with two binding sites are emerging strategies in medicinal chemistry. We have designed, synthesized and functionally characterized the first bitopic ligands for the CB2 receptor. These compounds selectively target CB2 versus CB1 receptors. Their binding mode was studied by molecular dynamic simulations and site-directed mutagenesis. 相似文献
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J. L. Redondo J. Fernández I. García P. M. Ortigosa 《Journal of Global Optimization》2011,50(4):557-573
We consider a continuous location problem in which a firm wants to set up two or more new facilities in a competitive environment.
Both the locations and the qualities of the new facilities are to be found so as to maximize the profit obtained by the firm.
This hard-to-solve global optimization problem has been addressed in Redondo et al. (Evol. Comput.17(1), 21–53, 2009) using
several heuristic approaches. Through a comprehensive computational study, it was shown that the evolutionary algorithm uego is the heuristic which provides the best solutions. In this work, uego is parallelized in order to reduce the computational time of the sequential version, while preserving its capability at finding
the optimal solutions. The parallelization follows a coarse-grain model, where each processing element executes the uego algorithm independently of the others during most of the time. Nevertheless, some genetic information can migrate from a
processor to another occasionally, according to a migratory policy. Two migration processes, named Ring-Opt and Ring-Fusion2,
have been adapted to cope the multiple facilities location problem, and a superlinear speedup has been obtained. 相似文献