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1.
Redondo Mara Julia Romn Lucrecia Rossi Bertone Fiorela Verdecchia Melina 《Algebras and Representation Theory》2022,25(4):1037-1059
Algebras and Representation Theory - Let A and B be two Morita equivalent finite dimensional associative algebras over a field . It is well known that Hochschild cohomology is... 相似文献
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A.?Arhrib R.?BenbrikEmail author Chuan-Hung?Chen Melina?Gomez-Bock Souad?Semlali 《The European Physical Journal C - Particles and Fields》2016,76(6):328
We study the constraints of the generic two-Higgs-doublet model (2HDM) type-III and the impacts of the new Yukawa couplings. For comparisons, we revisit the analysis in the 2HDM type-II. To understand the influence of all involving free parameters and to realize their correlations, we employ a \(\chi \)-square fitting approach by including theoretical and experimental constraints, such as the S, T, and U oblique parameters, the production of standard model Higgs and its decay to \(\gamma \gamma \), \(WW^*/ZZ^*\), \(\tau ^+\tau ^-\), etc. The errors of the analysis are taken at 68, 95.5, and \(99.7~\%\) confidence levels. Due to the new Yukawa couplings being associated with \(\cos (\beta -\alpha )\) and \(\sin (\beta -\alpha )\), we find that the allowed regions for \(\sin \alpha \) and \(\tan \beta \) in the type-III model can be broader when the dictated parameter \(\chi _F\) is positive; however, for negative \(\chi _F\), the limits are stricter than those in the type-II model. By using the constrained parameters, we find that the deviation from the SM in \(h\rightarrow Z\gamma \) can be of \(\mathcal{O}(10~\%)\). Additionally, we also study the top-quark flavor-changing processes induced at the tree level in the type-III model and find that when all current experimental data are considered, we get \(Br(t\rightarrow c(h, H) )< 10^{-3}\) for \(m_h=125.36\) and \(m_H=150\) GeV, and \(Br(t\rightarrow cA)\) slightly exceeds \(10^{-3}\) for \(m_A =130\) GeV. 相似文献
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We consider four-dimensional variational data assimilation (4DVar) and show that it can be interpreted as Tikhonov or L2-regularisation, a widely used method for solving ill-posed inverse problems. It is known from image restoration and geophysical problems that an alternative regularisation, namely L1-norm regularisation, recovers sharp edges better than L2-norm regularisation. We apply this idea to 4DVar for problems where shocks and model error are present and give two examples which show that L1-norm regularisation performs much better than the standard L2-norm regularisation in 4DVar. (© 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim) 相似文献
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The aim of this study was to develop a fast CE separation method by using multiple short-end injections in a capillary coated with quaternary ammonium chitosan (HACC), in order to determine the iodide content of pharmaceutical formulations. The BGE was composed of 20 mM tris(hydroxymethyl)aminomethane and 11 mM hydrochloric acid, at pH 8. The internal standard used was thiocyanate. Separations were performed in a fused silica capillary (32 cm total length, 8.5 cm effective length and 50 μm i.d.) coated with HACC and direct UV detection at 220 nm. EOF was modified by flushing the capillary with polymeric solution, resulting in a semi-permanent coating of controlled and stable EOF. The EOF was anodic at pH 8. Different strategies, using single and multiple injection short-end configurations, were studied to develop a CE method that resulted in a maximum number of iodide samples analyzed per hour: one plug and flush (Sflush) 35 samples/h, one plug without flush (SWflush) 76 samples/h, four plugs and flush (Mflush) 61 samples/h, and four plugs without flush (MWflush) 80 samples/h. Using the multiple injection configuration, it was possible to inject up to four plugs using spacer electrolytes with good separation efficiency and selectivity. The voltage application time needed to separate the eight peaks (iodide and thiocyanate) with MWflush was only 12s. The method was validated and samples were analyzed using MWflush. Good linearity (R(2)>0.999); a limit of detection 0.4 mg L(-1); intermediate precision better than 3.8% (peak area) and recovery in the range of 99-102% were obtained. 相似文献
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Tatiane Melina Guerreiro Diogo Noin de OliveiraMônica Siqueira Ferreira Rodrigo Ramos Catharino 《Analytica chimica acta》2014
Balsamic vinegar (BV) is a typical and valuable Italian product, worldwide appreciated thanks to its characteristic flavors and potential health benefits. Several studies have been conducted to assess physicochemical and microbial compositions of BV, as well as its beneficial properties. Due to highly-disseminated claims of antioxidant, antihypertensive and antiglycemic properties, BV is a known target for frauds and adulterations. For that matter, product authentication, certifying its origin (region or country) and thus the processing conditions, is becoming a growing concern. Striving for fraud reduction as well as quality and safety assurance, reliable analytical strategies to rapidly evaluate BV quality are very interesting, also from an economical point of view. This work employs silica plate laser desorption/ionization mass spectrometry (SP-LDI-MS) for fast chemical profiling of commercial BV samples with protected geographical indication (PGI) and identification of its adulterated samples with low-priced vinegars, namely apple, alcohol and red/white wines. 相似文献
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Carrasco H Raimondi M Svetaz L Di Liberto M Rodriguez MV Espinoza L Madrid A Zacchino S 《Molecules (Basel, Switzerland)》2012,17(1):1002-1024
Twenty one phenylpropanoids (including eugenol and safrole) and synthetic analogues, thirteen of them new compounds, were evaluated for antifungal properties, first with non-targeted assays against a panel of human opportunistic pathogenic fungi. Some structure-activity relationships could be observed, mainly related to the influence of an allyl substituent at C-4, an OH group at C-1 and an OCH(3) at C-2 or the presence of one or two NO(2) groups in different positions of the benzene ring. All active compounds were tested in a second panel of clinical isolates of C. albicans and non-albicans Candida spp., Cryptococcus neoformans and dermatophytes. The eugenol derivative 4-allyl-2-methoxy-5-nitrophenol (2) was the most active structure against all strains tested, and therefore it was submitted to targeted assays. These studies showed that the antifungal activity of 2 was not reversed in the presence of an osmotic support such as sorbitol, suggesting that it does not act by inhibiting the fungal cell wall synthesis or assembly. On the other hand, the Ergosterol Assay showed that 2 did not bind to the main sterol of the fungal membrane up to 250 μg mL-1. In contrast, a 22% of fungal membrane damage was observed at concentrations = 1 × MIC and 71% at 4× MIC, when 2 was tested in the Cellular Leakage assay. The comparison of log P and MICs for all compounds revealed that the antifungal activity of the eugenol analogues would not to be related to lipophilicity. 相似文献
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We present a new fast algorithm to compute the real stability radius with respect to the open left half plane which is an important problem in many engineering applications. The method is based on a well-known formula for the real stability radius and the correspondence of singular values of a transfer function to pure imaginary eigenvalues of a three-parameter Hamiltonian matrix eigenvalue problem. We then apply the implicit determinant method, used previously by the authors to compute the complex stability radius, to find the critical point corresponding to the desired singular value. This corresponds to a two-dimensional Jordan block for a pure imaginary eigenvalue in the parameter dependent Hamiltonian matrix. Numerical results showing quadratic convergence of the algorithm are given. 相似文献
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Neel A. Mansukhani Erica B. Peters Miranda M. So Mazen S. Albaghdadi Zheng Wang Mark R. Karver Tristan D. Clemons Jeffrey P. Laux Nick D. Tsihlis Samuel I. Stupp Melina R. Kibbe 《Macromolecular bioscience》2019,19(6)
The rising prevalence of cardiovascular disease worldwide necessitates novel therapeutic approaches to manage atherosclerosis. Intravenously administered nanostructures are a promising noninvasive approach to deliver therapeutics that reduce plaque burden. The drug liver X receptor agonist GW3965 (LXR) can reduce atherosclerosis by promoting cholesterol efflux from plaque but causes liver toxicity when administered systemically at effective doses, thus preventing its clinical use. The ability of peptide amphiphile nanofibers containing apolipoprotein A1–derived targeting peptide 4F to serve as nanocarriers for LXR delivery (ApoA1‐LXR PA) in vivo is investigated here. These nanostructures are found to successfully target atherosclerotic lesions in a mouse model within 24 h of injection. After 8 weeks of intravenous administration, the nanostructures significantly reduce plaque burden in both male and female mice to a similar extent as LXR alone in comparison to saline‐treated controls. Furthermore, they do not cause increased liver toxicity in comparison to LXR treatments, which may be related to more controlled release by the nanostructure. These findings demonstrate the potential of supramolecular nanostructures as safe, effective drug nanocarriers to manage atherosclerosis. 相似文献
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Melina Knezevic Michael Heilmann Giovanni Maria Piccini Konrad Tiefenbacher 《Angewandte Chemie (International ed. in English)》2020,59(30):12387-12391
The site‐selective C?H oxidation of unactivated positions in aliphatic ammonium chains poses a tremendous synthetic challenge, for which a solution has not yet been found. Here, we report the preferential oxidation of the strongly deactivated C3/C4 positions of aliphatic ammonium substrates by employing a novel supramolecular catalyst. This chimeric catalyst was synthesized by linking the well‐explored catalytic moiety Fe(pdp) to an alkyl ammonium binding molecular tweezer. The results highlight the vast potential of overriding the intrinsic reactivity in chemical reactions by guiding catalysis using supramolecular host structures that enable a precise orientation of the substrates. 相似文献