Simultaneous quantification of ondansetron and tariquidar in rat and human plasma using a high performance liquid chromatography‐ultraviolet method

Ondansetron, a widely used antiemetic agent, is a P‐glycoprotein (P‐gp) substrate and therefore expression of P‐gp at the blood–brain barrier limits its distribution to the central nervous system (CNS), which was observed to be reversed by coadministration with P‐gp inhibitors. Tariquidar is a potent and selective third‐generation P‐gp inhibitor, and coadministration with ondansetron has shown improved ondansetron distribution to the CNS. There is currently no reported bioanalytical method for simultaneously quantifying ondansetron with a third‐generation P‐gp inhibitor. Therefore, we aimed to develop and validate a method for ondansetron and tariquidar in rat and human plasma samples. A full validation was performed for both ondansetron and tariquidar, and sample stability was tested under various storage conditions. To demonstrate its utility, the method was applied to a preclinical pharmacokinetic study following coadministration of ondansetron and tariquidar in rats. The presented method will be valuable in pharmacokinetic studies of ondansetron and tariquidar in which simultaneous determination may be required. In addition, this is the first report of a bioanalytical method validated for quantification of tariquidar in plasma samples.     

A multigrid method for the ground state solution of Bose–Einstein condensates based on Newton iteration

BIT Numerical Mathematics - In this paper, a new kind of multigrid method is proposed for the ground state solution of Bose–Einstein condensates based on Newton iteration scheme. Instead of...     

奶粉功能化石墨烯的制备及其用于药物载体研究

本研究以奶粉为稳定剂和还原剂,绿色合成了新型的奶粉功能化石墨烯纳米片(mp-GNS),并且mp-GNS在水中和生理缓冲溶液中均表现出良好的分散性和稳定性.细胞毒性实验表明mp-GNS具有良好的生物相容性,药物吸附实验结果显示其对模型抗癌药物罗丹明6G(R6G)有较高的吸附容量.同时mp-GNS/R6G对R6G的释放具有...     

飞行试验测试采集的AFDX总线检测分析技术研究

在航空产品的航电系统跨代升级中,AFDX总线数据的检测分析是飞行试验对航空产品航电系统进行科研鉴定的一项重要技术手段,针对复杂航空电子环境下的采集记录的AFDX总线数据的多类、随机性等特点,提出了AFDX总线消息识别、帧检测、丢包检测分析方法及实现技术,并结合采用了AFDX总线周期检测分析算法,设计了AFDX总线的检测分析技术,实现了飞行试验AFDX总线的检测分析,最后在某试验机AFDX总线飞行试验测试中进行了应用,试验表明该AFDX总线检测分析技术满足飞行试验对航电系统进行科研鉴定的需求。     

基于关联ID的试飞FC总线ICD优化设计技术

为实现飞行试验航电总线FC数据海量ICD信息库的优化设计,从飞机航电总线设计数据库表中提取飞行试验FC总线数据分析所需的ICD信息,在关键的算法方面提出了解决方法;分析了新一代光纤通道航电总线FC的飞机设计ICD信息的数据结构特点,以及飞行试验传统航电总线ICD库的结构设计技术,针对新形势下的海量飞机设计航电总线FC的ICD信息的多重复杂结构,借鉴了飞行试验传统航电总线ICD库设计思想中成熟的四层结构技术,设计了飞行试验海量FC总线关联ID的ICD库设计技术,实现了飞行试验FC总线海量ICD信息的优化设计,最后在某试验机航电系统飞行试验中进行了应用,试验表明FC总线ICD优化设计技术满足海量FC数据的高效数据处理的需求。     

基于平稳小波变换的时域光学相干层析系统

以平衡检测原理为基础,利用中心波长为700 nm的宽带低相干白光光源,在自由空间中搭建了分辨率为0.93 m的基于平稳小波变换（SWT）的时域光学相干层析（TDOCT）系统,并将其应用于塑料薄片与透明胶纸多层薄膜结构的无损评价。针对现有算法重构效果不够理想的问题,通过对OCT成像过程中的图像增强手段的对比,提出利用SWT分解算法处理多层薄膜结构的光学相干层析二维图像。由薄膜检测的实验结果可知,从SWT细节系数中可以提取更显著的多层薄膜界面干涉信号,从而提高多层薄膜界面的增强效果。