Conjugated polymer nanoparticles with aggregation induced emission characteristics for intracellular Fe3+ sensing

In this article, a novel zwitterionic conjugated polyelectrolyte containing tetraphenylethene unit was synthesized via Pd‐catalyzed Sonogashira reaction. The resulting polymer (P2), which exhibited typical aggregation‐induced emission (AIE) properties, was weakly fluorescent in dilute DMSO solution and showed bright fluorescence emissions when aggregated in DMSO/water mixtures or fabricated into conjugated polymer nanoparticles (CPNs). The nanoparticles from P2 could be prepared by reprecipitation method with an average diameter around 23 nm. Notably, the cell‐staining efficiencies of lipid‐P2 nanoparticles could be enhanced with lipid encapsulation and these nanoparticles were endocytosed via caveolae‐mediated and clathrin‐mediated endocytosis pathways. Furthermore, the lipid‐P2 nanoparticles with low cytotoxicity, high photostability and efficient cell staining ability could be employed for in vitro detection of Fe³⁺ ions in A549 cells. © 2016 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2016 , 54, 1686–1693     

Antimicrobial and antioxidant activities of a new benzamide from endophytic Streptomyces sp. YIM 67086

A new benzamide (1) and four known compounds (2–5) were isolated from endophytic Streptomyces YIM67086, and their structures were determined as 2-amino-3,4-dihydroxy-5-methoxybenzamide (1), 4-hydroxy-3-methoxybenzoic acid (2), phenylacetic acid (3), N-acetyltyramine (4) and p-hydroxytruxinic acid (5). Compound 5 was first found in the microorganism. The antimicrobial activities of compounds 1–5 and antioxidant activity of compound 1 were investigated.     

A new natural nucleotide and other antibacterial metabolites from an endophytic Nocardia sp.

Nine compounds were isolated from Nocardia sp. YIM 64630, and their structures were elucidated as 5′-O-acetyl-2′-deoxyuridine (1), 22E,24R-5α,6α-epoxyergosta-8(14),22-diene-3β,7α-diol (2), 22E,24R-5α,6α-epoxyergosta-8,22-diene-3β,7α-diol (3), 22E,24R-ergosta-7,22-diene-3β,5α,6β-triol (4), 5α,8α-epidioxyergosta-6,22-dien-3β-ol (5), 4′,5,6-trihydroxy-7-methoxyisoflavone (6), 2,4,4′-trihydroxy-deoxybenzoin (7), methyl [4-hydroxyphenyl]acetate (8) and daidzein by extensive spectroscopic analyses. Compound 1 was isolated from natural resources for the first time. The antimicrobial and antioxidant activities of compounds 1–8 were investigated.     

A USM-Θ two-phase turbulence model for simulating dense gas-particle flows

A second-order moment two-phase turbulence model for simulating dense gas-particle flows (USM- model), combining the unified second-order moment two-phase turbulence model for dilute gas-particle flows with the kinetic theory of particle collision, is proposed. The interaction between gas and particle turbulence is simulated using the transport equation of two-phase velocity correlation with a two-time-scale dissipation closure. The proposed model is applied to simulate dense gas-particle flows in a horizontal channel and a downer. Simulation results and their comparison with experimental results show that the model accounting for both anisotropic particle turbulence and particle-particle collision is obviously better than models accounting for only particle turbulence or only particle-particle collision. The USM- model is also better than the k--kp- model and the k--kp-p- model in that the first model can simulate the redistribution of anisotropic particle Reynolds stress components due to inter-particle collision, whereas the second and third models cannot.The project supported by the Special Funds for Major State Basic Research of China (G-1999-0222-08), the National Natural Science Foundation of China (50376004), and Ph.D. Program Foundation, Ministry of Education of China (20030007028)     

给定寿命下的焊趾疲劳裂纹深度尺寸分析

本文提供并用统计方法研究了焊趾疲劳裂纹扩展的Ｎ～α曲线族，给出了联系给定裂纹尺寸下的疲劳分布，给定疲劳寿命下的裂纹尺寸分布以及随机初始条件的概率相容条件。研究表明，给定寿命下的焊趾疲劳裂纹深度尺寸α服从分布Ф［（μ（ａ）－ｌｏｇＮ）／σ（ａ）］。     

双柱单锥型液-液旋流管内流场的激光诊断

应用激光测速仪，对一种双柱单锥型液 液旋流管内的流动结构，进行了全场范围内的多工况流动诊断研究．揭示出其切向速度由内旋流区和外旋流区构成，其中内旋流区中的速度分布符合准强制涡关系，外旋流区中的速度分布符合准自由涡关系；轴向速度由上行流动区和下行流动区构成，两者之间在直管段以零速点作分界，在锥体段则以零速区作过渡并伴随有一定的回流出现，且该过渡区或回流区的大小随锥体截面的收缩而减小，直到进入直管段后消失；各湍流量的分布以管芯处最大向外逐渐减小，沿轴向是直管段中的湍流度大于锥体段中的湍流度，而且湍流度在旋流管内具有各向异性的特性．     

二阶矩两相湍流模型中的改进算法

建立了融合SIMPLEC算法在内的考虑了浓度修正影响的颗粒压力修正方程。提出了二阶矩湍流模型下考虑浓度修正值影响的两相湍流流动的算法,并将它和没有考虑浓度修正值影响的二阶矩湍流模型进行了对照。结果表明在二阶矩模型中是否考虑浓度修正影响会不同程度地影响流场的速度以及浓度等参数分布,考虑浓度修正影响的二阶矩湍流模型更能有效地预测稠密两相湍流流动。     

Pairwise distance-based heteroscedasticity test for regressions

Science China Mathematics - In this study, we propose nonparametric testing for heteroscedasticity in nonlinear regression models based on pairwise distances between points in a sample. The test...     

Functional Carbazole-Fullerene Complexes: A New Perspective of Carbazoles Acting as Nano-Octopus to Capture Globular Fullerenes

Fullerene host-guest constructs have attracted increasing attention owing to their molecular-level hybrid arrangements. However, the usage of simple carbazolic derivatives to bind with fullerenes is rare. In this research, three novel carbazolic derivatives, containing a tunable bridging linker and carbazole units for the capturing of fullerenes, are rationally designed. Unlike the general concave-convex interactions, fullerenes could interact with the planar carbazole subunits to form 2-dimensional hexagonal/quadrilateral cocrystals with alternating stacking patterns of 1 : 1 or 1 : 2 stoichiometry, as well as the controllable fullerene packing modes. At the meanwhile, good electron-transporting performances and significant photovoltaic effects were realized when a continuous C_60⋅⋅⋅C₆₀ interaction channel existed. The results indicate that the introduction of such carbazolic system into fullerene receptor would provide new insights into novel fullerene host-guest architectures for versatile applications.