全文获取类型
收费全文 | 743篇 |
免费 | 6篇 |
国内免费 | 1篇 |
专业分类
化学 | 242篇 |
晶体学 | 3篇 |
力学 | 26篇 |
数学 | 238篇 |
物理学 | 241篇 |
出版年
2021年 | 8篇 |
2020年 | 9篇 |
2019年 | 9篇 |
2018年 | 9篇 |
2016年 | 10篇 |
2015年 | 6篇 |
2014年 | 8篇 |
2013年 | 50篇 |
2012年 | 21篇 |
2011年 | 34篇 |
2010年 | 14篇 |
2009年 | 23篇 |
2008年 | 35篇 |
2007年 | 39篇 |
2006年 | 34篇 |
2005年 | 22篇 |
2004年 | 22篇 |
2003年 | 21篇 |
2002年 | 18篇 |
2001年 | 10篇 |
2000年 | 9篇 |
1997年 | 13篇 |
1996年 | 7篇 |
1995年 | 11篇 |
1994年 | 14篇 |
1993年 | 4篇 |
1992年 | 16篇 |
1991年 | 12篇 |
1990年 | 18篇 |
1989年 | 15篇 |
1988年 | 19篇 |
1987年 | 12篇 |
1986年 | 10篇 |
1985年 | 17篇 |
1984年 | 19篇 |
1983年 | 14篇 |
1982年 | 11篇 |
1981年 | 18篇 |
1980年 | 12篇 |
1979年 | 7篇 |
1978年 | 14篇 |
1977年 | 12篇 |
1976年 | 6篇 |
1975年 | 5篇 |
1974年 | 6篇 |
1973年 | 8篇 |
1972年 | 10篇 |
1971年 | 4篇 |
1969年 | 4篇 |
1967年 | 3篇 |
排序方式: 共有750条查询结果,搜索用时 15 毫秒
1.
Leah B. Casabianca 《Magnetic resonance in chemistry : MRC》2020,58(7):611-624
The nuclear magnetic resonance (NMR) chemical shift is extremely sensitive to molecular geometry, hydrogen bonding, solvent, temperature, pH, and concentration. Calculated magnetic shielding constants, converted to chemical shifts, can be valuable aids in NMR peak assignment and can also give detailed information about molecular geometry and intermolecular effects. Calculating chemical shifts in solution is complicated by the need to include solvent effects and conformational averaging. Here, we review the current state of NMR chemical shift calculations in solution, beginning with an introduction to the theory of calculating magnetic shielding in general, then covering methods for inclusion of solvent effects and conformational averaging, and finally discussing examples of applications using calculated chemical shifts to gain detailed structural information. 相似文献
2.
3.
Verena Bögelein Frank Duzaar Leah Schätzler Christoph Scheven 《Journal of Differential Equations》2019,266(11):7709-7748
We establish that solutions to the Cauchy–Dirichlet problem for functionals of linear growth can be obtained as limits of solutions to flows with p-growth in the limit . The result can be interpreted on the one hand as a stability result. On the other hand it provides an existence result for general flows with linear growth. 相似文献
4.
Patrick E. Hartnett Scott M. Dyar Eric A. Margulies Leah E. Shoer Andrew W. Cook Samuel W. Eaton Tobin J. Marks Michael R. Wasielewski 《Chemical science》2015,6(1):402-411
The photophysics of a covalently linked perylenediimide–diketopyrrolopyrrole–perylenediimide acceptor–donor–acceptor molecule (PDI–DPP–PDI, 1) were investigated and found to be markedly different in solution versus in unannealed and solvent annealed films. Photoexcitation of 1 in toluene results in quantitative charge separation in τ = 3.1 ± 0.2 ps, with charge recombination in τ = 340 ± 10 ps, while in unannealed/disordered films of 1, charge separation occurs in τ < 250 fs, while charge recombination displays a multiexponential decay in ∼6 ns. The absence of long-lived, charge separation in the disordered film suggests that few free charge carriers are generated. In contrast, upon CH2Cl2 vapor annealing films of 1, grazing-incidence X-ray scattering shows that the molecules form a more ordered structure. Photoexcitation of the ordered films results in initial formation of a spin-correlated radical ion pair (electron–hole pair) as indicated by magnetic field effects on the formation of free charge carriers which live for ∼4 μs. This result has significant implications for the design of organic solar cells based on covalent donor–acceptor systems and shows that long-lived, charge-separated states can be achieved by controlling intramolecular charge separation dynamics in well-ordered systems. 相似文献
5.
Levi Evans Yiqui Shen Abigail Bender Leah E. Burnett Musheng Li Justine S. Habibian Tong Zhou Bradley S. Ferguson 《Molecules (Basel, Switzerland)》2021,26(5)
Plant-based foods, like fruits, vegetables, whole grains, legumes, nuts, seeds and other foodstuffs, have been deemed as heart healthy. The chemicals within these plant-based foods, i.e., phytochemicals, are credited with protecting the heart. However, the mechanistic actions of phytochemicals, which prevent clinical endpoints, such as pathological cardiac hypertrophy, are still being elucidated. We sought to characterize the overlapping and divergent mechanisms by which 18 selected phytochemicals prevent phenylephrine- and phorbol 12-myristate 13-acetate-mediated cardiomyocyte enlargement. Of the tested 18 compounds, six attenuated PE- and PMA-mediated enlargement of neonatal rat ventricular myocytes. Cell viability assays showed that apigenin, baicalein, berberine hydrochloride, emodin, luteolin and quercetin dihydrate did not reduce cell size through cytotoxicity. Four of the six phytochemicals, apigenin, baicalein, berberine hydrochloride and emodin, robustly inhibited stress-induced hypertrophy and were analyzed further against intracellular signaling and genome-wide changes in mRNA expression. The four phytochemicals differentially regulated mitogen-activated protein kinases and protein kinase D. RNA-sequencing further showed divergence in gene regulation, while pathway analysis demonstrated overlap in the regulation of inflammatory pathways. Combined, this study provided a comprehensive analysis of cardioprotective phytochemicals. These data highlight two defining observations: (1) that these compounds predominantly target divergent gene pathways within cardiac myocytes and (2) that regulation of overlapping signaling and gene pathways may be of particular importance for the anti-hypertrophic actions of these phytochemicals. Despite these new findings, future works investigating rodent models of heart failure are still needed to understand the roles for these compounds in the heart. 相似文献
6.
G. P. Berman 《Journal of Applied Mechanics and Technical Physics》1974,15(3):424-426
The article discusses transverse vibrations of finite amplitude in an electron-ion ring. Far from the region of linear resonances, an equation is obtained for slowly varying amplitudes, and the conditions are found for the excitation of instability of the negative pressure type. Near the lower boundary of the region of linear instability, the conditions are found under which nonlinearity breaks down the stability of the vibrations with finite amplitudes.Translated from Zhurnal Prikladnoi Mekhaniki i Tekhnicheskoi Fiziki, No. 3, pp. 170–172, May–June, 1974.The author is indebted to B. V. Chirikov for his evaluation of the results of the work. 相似文献
7.
8.
Friction factors and velocity profiles in turbulent drag reduction can be compared to Newtonian fluid turbulence when the shear viscosity at the wall shear rate is used for the Reynolds number and the local shear viscosity is used for the non-dimensional wall distance. On this basis, an apparent maximum drag reduction asymptote is found which is independent of Reynolds number and type of drag reducing additive. However, no shear viscosity is able to account for the difference between the measured Reynolds stress and the Reynolds stress calculated from the mean velocity profile (the Reynolds stress deficit). If the appropriate local viscosity to use with the velocity fluctuation correlations includes an elongational component, the problem can be resolved. Taking the maximum drag reduction asymptote as a non-Newtonian flow, with this effective viscosity, leads to agreement with the concept of an asymptote only when the solvent viscosity is used in the non-dimensional wall distance. 相似文献
9.
Saturation-transfer difference (STD)-NMR spectroscopy has been widely used to screen potential ligands for binding to large receptor molecules. The STD-NMR experiment is typically based on a proton NMR spectrum, which can suffer from spectral overlap, leading to missing information in STD-based epitope mapping. Two-dimensional STD-NMR experiments can alleviate spectral overlap, but are time consuming. Here, we examine the feasibility of saturating protons in a receptor molecule and observing the STD effect on nearby carbon nuclei after transferring polarization from protons to carbons using the insensitive nuclei enhanced by polarization transfer (INEPT) pulse sequence. We show that under favorable conditions, a 1H→13C STD-INEPT experiment can give information similar to that obtained from a two-dimensional heteronuclear experiment, but in significantly less time. The STD-INEPT experiment could be especially useful when studying mixtures of ligands in which the peak positions in the proton and HSQC spectrum change significantly, and in particular, when using high-throughput, automated methods to analyze the data. 相似文献
10.