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排序方式: 共有181条查询结果,搜索用时 15 毫秒
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Dr. Konstantin I. Galkin Bogdan Ya. Karlinskii Dr. Alexander Yu. Kostyukovich Dr. Evgeniy G. Gordeev Prof. Dr. Valentine P. Ananikov 《Chemistry (Weinheim an der Bergstrasse, Germany)》2020,26(39):8567-8571
This work reveals ambident nucleophilic reactivity of imidazolium cations towards carbonyl compounds at the C2 or C4 carbene centers depending on the steric properties of the substrates and reaction conditions. Such an adaptive behavior indicates the dynamic nature of organocatalysis proceeding via a covalent interaction of imidazolium carbenes with carbonyl substrates and can be explained by generation of the H-bonded ditopic carbanionic carbenes. 相似文献
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Margarita Yu. Vozhdaeva Alfiya R. Kholova Igor A. Melnitskiy Ilya I. Beloliptsev Yulia S. Vozhdaeva Evgeniy A. Kantor Albert T. Lebedev 《Molecules (Basel, Switzerland)》2021,26(7)
The main drawback of drinking water chlorination involves the formation of quite hazardous disinfection by-products (DBPs), represented mainly by halogenated species. Based on the authors’ monitoring data since 2002, the prevalence of chlorine over bromine in the composition of volatile DBPs was shown for the drinking water in Ufa (Russia). However, the situation was completely reversed in the case of semi-volatile DBPs. The principal goal of the present study involved rationalization of the results of the long-term monitoring. Gas chromatography–mass spectrometry (GC-MS) was used for the qualitative and quantitative analysis of volatile DBPs. Identification of semi-volatile compounds was carried out with GC-MS, while gas chromatography with an atomic emission detector (GC-AED) was used for their quantification. A significant contribution of oxygen to the composition of semi-volatile compounds proves the decisive role of the dissolved organic matter oxidative destructive processes. Statistical analysis revealed notable linear correlations for trihalomethane and haloacetic acid formation vs. chlorine dose. On the contrary, halogenated semi-volatile products do not demonstrate any correlations with the water quality parameters or chlorine dose. Principal component analysis (PCA) placed them into separate groups. The results allow for proposing that formation of the organohalogenated species involved the fast penetration of bromine into the humic matter molecules and, further, their oxidative destruction by active chlorine. 相似文献
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Aldar A. Munkuev Evgenii S. Mozhaitsev Arina A. Chepanova Evgeniy V. Suslov Dina V. Korchagina Olga D. Zakharova Ekaterina S. Ilina Nadezhda S. Dyrkheeva Alexandra L. Zakharenko Jhannes Reynisson Konstantin P. Volcho Nariman F. Salakhutdinov Olga I. Lavrik 《Molecules (Basel, Switzerland)》2021,26(11)
Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is a promising target for anticancer therapy due to its ability to counter the effects topoisomerase 1 (Top1) poison, such as topotecan, thus, decreasing their efficacy. Compounds containing adamantane and monoterpenoid residues connected via 1,2,4-triazole or 1,3,4-thiadiazole linkers were synthesized and tested against Tdp1. All the derivatives exhibited inhibition at low micromolar or nanomolar concentrations with the most potent inhibitors having IC50 values in the 0.35–0.57 µM range. The cytotoxicity was determined in the HeLa, HCT-116 and SW837 cancer cell lines; moderate CC50 (µM) values were seen from the mid-teens to no effect at 100 µM. Furthermore, citral derivative 20c, α-pinene-derived compounds 20f, 20g and 25c, and the citronellic acid derivative 25b were found to have a sensitizing effect in conjunction with topotecan in the HeLa cervical cancer and colon adenocarcinoma HCT-116 cell lines. The ligands are predicted to bind in the catalytic pocket of Tdp1 and have favorable physicochemical properties for further development as a potential adjunct therapy with Top1 poisons. 相似文献
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Evgeniy Pustylnik Simeon Reich Alexander J. Zaslavski 《Journal of Approximation Theory》2012,164(5):611-624
We provide sufficient conditions for strong and uniform (on bounded subsets of initial points) convergence of infinite products of orthogonal projections and other (possibly nonlinear) nonexpansive operators in a Hilbert space. Our main tools are new estimates of the inclination of a finite tuple of closed linear subspaces. 相似文献