大白鼠中缝大核含5-羟色胺的神经元的电生理学鉴定

本文报道由逆行刺激激活的中缝大核内的缝-脊神经元,其轴突传导速度和自发放电率变异甚大。比较对照动物和事先给5,6-双羟色胺(一种专一作用于5-羟色胺细胞的神经毒)的动物的缝-脊神经元的电活动,发现在给药动物找不到传导速度慢于12m/s、自发放电率又低于3Hz的单位活动,故具备这两特征的神经元被判别为含5-羟色胺的。此外,还用锋电位间隔的变异系数来测试各单位自发放电的规则性,结果表明传导速度慢的单位放电比传导速度快的更不规则。     

ELECTROPHYSIOLOGICAL IDENTIFICATION OF SEROTONERGIC NEURONS IN THE RAT NUCLEUS RAPHE MAGNUS

In the present study, antidromically activated raphe-spinal neurons in the nucleus raphe magnus are found to exhibit a wide range of conduction velocities and spontaneous discharge rates. The unit activities observed in control rats have been compared with those in 5,6-dihydroxtryptamine(a specific neurotoxin to serotonergie cells)-pretreated animals. It is found that the units conducting at slower than 12 m/sec and discharging at rates of less than 3 Hz often found in control rats are not found in drug-pretreated animals, and are thus presumed to be serotonergic. In addition, the regularity of spontaneous discharges of units has been evaluated by testing the coefficient of variability of spike intervals. These results indicate that the slow-conducting units discharge less regularly than the fast-conductlng ones.     

针刺镇痛效应外周传入途径的分析

实验在21位正常成年人上进行。结果显示,针刺左手的一个穴位可以提高体表许多部位的痛阈;阻断左上肢的体液循环不影响这种针刺镇痛效应;相反,普鲁卡因封闭针刺穴位的深层组织后,可以完全取消此效应。这提示针刺效应的传入途径是神经,而不是体液。此外,还根据各个痛阈测试点的阈值变化,分析出针刺镇痛效应呈左右对称分布,并且,效应点与针刺点之间可能具有节段联系。