β-氨基腈类化合物的合成研究进展

近年来,β-氨基腈类化合物的合成与应用有了很大的进展,引起人们的广泛关注。由于旋光纯的β-氨基腈类化合物及其衍生物是非常重要的药物合成中间体,因此新的简捷、低成本不对称合成方法的研究与开发仍然是必要的。本文比较全面而又简要地综述了β-氨基腈类化合物的合成方法,并对该领域的今后发展方向进行了展望。     

Algorithmic tangent modulus at finite strains based on multiplicative decomposition简

The algorithmic tangent modulus at finite strains in current configuration plays an important role in the nonlinear finite element method. In this work, the exact tensorial forms of the algorithmic tangent modulus at finite strains are derived in the principal space and their corresponding matrix expressions are also presented. The algorithmic tangent modulus consists of two terms. The first term depends on a specific yield surface, while the second term is independent of the specific yield surface. The elastoplastic matrix in the principal space associated with the specific yield surface is derived by the logarithmic strains in terms of the local multiplicative decomposition. The Drucker-Prager yield function of elastoplastic material is used as a numerical example to verify the present algorithmic tangent modulus at finite strains.     

非局部模型与变形局部化数值模拟

基于非线性身体场论,建立了材料非局部连续模型、变分方程及相应的实时拖带系大变形有限元数值模型,设计了这一模型的数值卷积算法,由于广义函数弱收敛定理和卷积理论,证明所提出的非局部连续模型具备收敛性和稳定性。并阐明了材料特征尺度数学物理意义,统计加权函数的选择原则,数值结果表明非局部模型描述变形局部化问题是适当的。     

β-乙酰氨基环戊烯腈的不对称催化氢化

利用不对称催化氢化法制备β乙酰氨基环戊腈,并考察了配体、催化剂前体、溶剂、温度、压力以及时间对反应活性和对映选择性的影响.实验结果表明,在优化条件下,[ Rh( COD)-DuanPhos] BF4催化不对称氢化β-乙酰氨基环戊烯腈的转化率为61％,对映体的ee值为60％.