Simulation of tumor microvasculature and microenvironment response to anti-angiogenic treatment by angiostatin and endostatin

The effects of anti-angiogenesis treatment by angiostatin and endostatin on normalization of tumor microvasculature and microenvironment are investigated, based on mathematical modeling and numerical simulation of tumor anti-angiogenesis and tumor haemodynamics. The results show that after anti-angiogenesis treatment: (i) the proliferation, growth, and branching of neo-vessels are effectively inhibited, and the extent of vascularization in tumors is accordingly reduced. (ii) the overall blood perfusion inside of tumor is declined, the plateau of tumor interstitial fluid pressure (IFP) is relieved, the interstitial fluid oozing out from the tumor periphery into the surrounding normal tissue is reduced, the reduction of overall extravasation across vasculature to tumor interstium is much less than the decreased overall blood perfusion, due to the decline of IFP, the intravasations is remarkablely effected by the change, in some cases there are no intravasation flow appear.     

不对称入口速度剖面对两种类型颈动脉分又模型外侧壁切应力的影响

在定常流不对称人口速度剖面条件下,对健康型和致病型颈动脉分叉TF-AHCB模型进行实验和数值模拟研究,发现不对称人口速度剖面的形状对模型外侧壁的低切应力和切应力速度分布有明显影响。在50°模型窦前部的壁面切应力梯度比20°模型高出数倍,当人口速度剖面向颈内动脉偏斜时更可高出10倍以上。这些结果对认识导致动脉粥样硬化斑块的血流动力学因子的影响因素有重要参考价值。     

血管抑素与内皮抑素作用下抗血管生成治疗对肿瘤微血管网与微环境影响的模拟研究

基于对血管抑素和内皮抑素作用下肿瘤抗血管生成及血液动力学的数学建模与数值模拟,研究抗血管生成治疗对肿瘤微血管网的影响及对微环境流动的改善作用．研究表明,抗血管生成治疗后:1） 新生血管的生长与分叉受到抑制,血管化程度降低;2） 血液灌注量减少,间质高压得到缓解,渗入宿主组织的间质液减少,负向跨壁流量大幅下降．     

试论静力学在流体力学课程中的地位

从材料的本构方程和基本运动方程出发, 比较了静力学在弹性力学和流体力学中的 地位. 与弹性静力学在弹性力学中占有重要地位不同, 流体静力学在流体力学中仅处 于次要地位, 它不是流体动力学的基础, 而只是一个特例. 确立这种观点有助于提高对流体 力学学科特点的认识, 提高流体力学教学质量.     

硬脑膜受压膨出挠度的力学分析

硬脑膜是一种粘弹性材料,为控制硬脑膜在脑压作用下的膨出度,对粘弹性薄膜受压膨出挠度作力学分析。以位移为未知量,从粘弹性材料的分型本构关系出发将Foepple薄膜大挠度理论从弹性推广到粘弹性膜,得到一组非线性积分偏微分方程。先在空间上运用Galerkin方法将积分偏微分方程组化为积分常微分方程组。然后,在时间域上运用数值积分和有限差分将方程离散为非线性代数方程组。本文对四周固定夹紧的圆形、椭圆形和矩形薄膜进行了求解,并将求解结果用于颅底缺损重建膜的膨出量计算,计算值与实验值吻合,为颅底外科提供一个理论分析方法。