Modeling and design of a tuned liquid damper using triangular-bottom tank by a concentrated mass model

Nonlinear Dynamics - Rectangular flat-bottom liquid tanks known as tuned liquid dampers (TLDs) are often used as passive mechanical dampers. Sloped- and triangular-bottom TLDs have been reported to...     

Depth estimation of protoporphyrin IX objects in turbid media considering the fluorescence intensity ratio between two wavelengths of light for application in invasion diagnosis of gastric cancer

Optical Review - This paper demonstrates a method to estimate the depth of a fluorescence object in turbid media using dual-wavelength excited photodynamic diagnosis, to aid in the invasion depth...     

On the rate of convergence of solutions in free boundary problems via penalization

The rate of convergence of approximate solutions via penalization for free boundary problems are concerned. A key observation is to obtain global bounds of penalized terms which give necessary estimates on integrations by the nonlinear adjoint method by L.C. Evans.     

12-Epi-9-deacetoxyxenicin,new cytotoxic diterpenoid from a Bornean soft coral,Xenia sp.

One new compound, 12-epi-9-deacetoxyxenicin (1) along with a hydroperoxide product, 12-epi-9-deacetoxy-8-hydroperoxyxenicin (2) and two known sesquiterpenoids (3–4) were isolated from a population of Bornean soft coral Xenia sp. The structures of these secondary metabolites were elucidated based on their spectroscopic data. Compounds 1 and 2 showed cytotoxic activity against ATL cell line, S1T. In addition, compound 3 exhibited hyphal inhibition of Lagenidium thermophilum.     

Optimizing Charge Switching in Membrane Lytic Peptides for Endosomal Release of Biomacromolecules

Endocytic pathways are practical routes for the intracellular delivery of biomacromolecules. Along with this, effective strategies for endosomal cargo release into the cytosol are desired to achieve successful delivery. Focusing on compositional differences between the cell and endosomal membranes and the pH decrease within endosomes, we designed the lipid-sensitive and pH-responsive endosome-lytic peptide HAad. This peptide contains aminoadipic acid (Aad) residues, which serve as a safety catch for preferential permeabilization of endosomal membranes over cell membranes, and His-to-Ala substitutions enhance the endosomolytic activity. The ability of HAad to destabilize endosomal membranes was supported by model studies using large unilamellar vesicles (LUVs) and by increased intracellular delivery of biomacromolecules (including antibodies) into live cells. Cerebral ventricle injection of Cre recombinase with HAad led to Cre/loxP recombination in a mouse model, thus demonstrating potential applicability of HAad in vivo.     

Effect of Alkynyl Group on Reactivity in Photoaffinity Labeling with 2-Thienyl-Substituted α-Ketoamide

Minimalist photo-reactive probes, which consist of a photo-reactive group and a tag for detection of target proteins, are useful tools in chemical biology. Although several diazirine-based and aryl azide-based minimalist probes are available, no keto-based minimalist probe has yet been reported. Here we describe minimalist probes based on a 2-thienyl-substituted α-ketoamide bearing an alkyne group on the thiophene ring. The 3-alkyne probe showed the highest photo-affinity labeling efficiency.