Formation of bifunctional cross-linked products due to reaction of NAMI-A with DNA bases – a DFT study

Structural Chemistry - It is reported that NAMI-A and other Ru-anticancer complexes preferably bind with the N7 site of guanine and can also form DNA inter-strand cross-links. Therefore, in order...     

Easy and Efficient Microwave-Assisted Synthesis of 1,2,3-Triazolyl-Tethered 2-Pyridinylbenzimidiazoles and Their Antimicrobial Activity

Russian Journal of Organic Chemistry - A series of novel 1,2,3-triazole-tethered 2-pyridinylbenzimidazole derivatives have been synthesized form 2-(pyridine-3-yl)benzimidazole under microwave...     

Determination of trace amounts of uranium in plutonium oxide by wavelength dispersive X-ray fluorescence spectrometry

Journal of Radioanalytical and Nuclear Chemistry - 149Tb, 152Tb, 155Tb and 161Tb can cover all the modalities of diagnostic and therapeutic purposes of nuclear medicine. The production cross...     

Quantification of β-Sitosterol in Hairy Root Cultures and Natural Plant Parts of Butterfly Pea (Clitoria ternatea L.)

JPC – Journal of Planar Chromatography – Modern TLC - A simple normal-phase high-performance thin-layer chromatography (HPTLC) method has been developed for the quantification of...     

Isometric multipliers of a vector valued Beurling algebra on a discrete semigroup

Let (S,ω) be a weighted abelian semigroup, let M _ω (S) be the semigroup of ω-bounded multipliers of S, and let \(\mathcal {A}\) be a strictly convex commutative Banach algebra with identity. It is shown that T is an onto isometric multiplier of \(\ell ^{1}(S,\omega , \mathcal {A})\) if and only if there exists an invertible σ ∈ M _ω (S), a unitary point \(a \in \mathcal {A}\), and a k>0 such that \(T(f)= ka{\sum }_{x \in S} f(x)\delta _{\sigma (x)}\) for each \(f={\sum }_{x \in S}f(x)\delta _{x} \in \ell ^{1}(S,\omega ,\mathcal {A})\). It is also shown that an isomorphism from \(\ell ^{1}(S_{1},\omega _{1},\mathcal {A})\) onto \(\ell ^{1}(S_{2},\omega _{2}, \mathcal {B})\) induces an isomorphism from \(M(\ell ^{1}(S_{1},\omega _{1},\mathcal {A}))\), the set of all multipliers of \(\ell ^{1}(S_{1},\omega _{1},\mathcal {A})\), onto \(M(\ell ^{1}(S_{2},\omega _{2},\mathcal {B}))\).     

Approximation of quadrilaterals by rational quadrilaterals in the plane

Many questions about triangles and quadrilaterals with rational sides, diagonals and areas can be reduced to solving certain diophantine equations. We look at a number of such questions including the question of approximating arbitrary triangles and quadrilaterals by those with rational sides, diagonals and areas. We transform these problems into questions on the existence of infinitely many rational solutions on a two parameter family of quartic curves. This is further transformed to a two parameter family of elliptic curves to deduce our main result concerning density of points on a line which are at a rational distance from three collinear points (Theorem 4). We deduce from this a new proof of density of rational quadrilaterals in the space of all quadrilaterals (Theorem 39). The other main result (Theorem 3) of this article is on the density of rational triangles which is related to analyzing rational points on the unit circle. Interestingly, this enables us to deduce that parallelograms with rational sides and area are dense in the class of all parallelograms. We also give a criterion for density of certain sets in topological spaces using local product structure and prove the density Theorem 6 in the appendix section. An application of this proves the density of rational points as stated in Theorem 31.     

Synthetic Heparanase Inhibitors Can Prevent Herpes Simplex Viral Spread

Herpes simplex virus (HSV-1) employs heparan sulfate (HS) as receptor for cell attachment and entry. During late-stage infection, the virus induces the upregulation of human heparanase (Hpse) to remove cell surface HS allowing viral spread. We hypothesized that inhibition of Hpse will prevent viral release thereby representing a new therapeutic strategy for HSV-1. A range of HS-oligosaccharides was prepared to examine the importance of chain length and 2-O-sulfation of iduronic moieties for Hpse inhibition. It was found that hexa- and octasaccharides potently inhibited the enzyme and that 2-O-sulfation of iduronic acid is tolerated. Computational studies provided a rationale for the observed structure–activity relationship. Treatment of human corneal epithelial cells (HCEs) infected with HSV-1 with the hexa- and octasaccharide blocked viral induced shedding of HS which significantly reduced spread of virions. The compounds also inhibited migration and proliferation of immortalized HCEs thereby providing additional therapeutic properties.     

Chemical Composition and Antioxidant Activity of the Leaf Essential Oil of Schefflera venulosa

Chemistry of Natural Compounds -     

Iodine-DMSO catalyzed chemoselective oxidative aromatization and deallylation,nondeallylation of aryl allyl ether of tetrahydro-β-carboline

We have developed a simple method for the chemoselective aromatization of tetrahydro-β-carboline with selective nondeallylation O-allyl groups in the presence of iodine (100 mol %) in dimethyl sulfoxide/H₂O₂. A convergent approach toward the oxidative aromatization with selective deallylation (deprotection) of O-allyl-tetrahydro-β-carboline using iodine in dimethyl sulfoxide/HCl has been described. The present protocol contains cheap catalyst, easy work up, normal reaction conditions, and high selectivity.     

Development of Pen-type Portable Electrochemical Sensor Based on Au-W Bimetallic Nanoparticles Decorated Graphene-chitosan Nanocomposite Film for the Detection of Nitrite in Water,Milk and Fruit Juices

The development and fabrication of a simple, portable, and sensitive detection tool to precisely monitor nitrite level is of growing importance in electrochemistry research, given the strong interest in the protection of drinking water quality, treatment of wastewater, food production, and control of remediation processes. This work describes the fabrication of a simple, cost-effective, pen-type electrochemical sensor based on bimetallic gold and tungsten nanoparticles electrochemically decorated on graphene-chitosan modified pencil graphite electrode (PGE) for the trace detection of nitrite in real samples. The prepared nanocomposite was characterized using XRD, SEM, and EDS. The electrochemical behavior of the sensor was evaluated by cyclic voltammetry (CV) and impedance electrochemical spectroscopy (EIS). Results revealed that the proposed sensor displayed excellent electrocatalytic activity towards electro-oxidation of nitrite with an irreversible redox reaction. The AuNPs-WNPs@Gr-Chi/PGE sensor exhibited excellent analytical performance with a wide linear range from 10 to 250 μM towards nitrite. The LOD and LOQ were calculated to be 0.12 μM and 0.44 μM, respectively. The designed electrochemical sensor was successfully applied for the detection of nitrite in water, milk, and natural fruit juice samples.