High-Throughput GC-FID Method for the Determination of Residual Solvents in Early-Phase Drug Discovery Samples

Chromatographia - In drug discovery environment, determination of residual solvents is indispensable and requires rapid analysis covering a maximum number of commonly used solvents especially with...     

Cu(I)‐Catalyzed Efficient Synthesis of 2′‐Triazolo‐nucleoside Conjugates

A small library of thirty‐two 2′‐triazolyl uridine and 2′‐triazolyl‐5‐methyluridine has been synthesized by Cu(I)‐catalyzed condensation of 2′‐azido‐2′‐deoxyuridine and 2′‐azido‐2′‐deoxy‐5‐methyluridine with different alkynes and aryl propargyl ethers in almost quantitative yields. Triazolo‐nucleoside conjugates, which can be evaluated for different biological activity for suitable drug development, were unambiguously identified on the basis of ¹H NMR, ¹³C NMR, IR, and HRMS data analysis. These compounds have been synthesized for the first time and have not been reported in the literature earlier.     

Transformation of hydrophobic surface into superhydrophobic surface by interfacial flower like silver films

Fabrication of superhydrophobic surface was achieved by electroless deposition of silver film and subsequent immersion into a mixture of stearic acid and cysteamine. The resultant superhydrophobic surface with flower and fall‐leaves like structure showed lotus leaf effect with the water contact angle of about 154° making copper surface water repellant. Copyright © 2014 John Wiley & Sons, Ltd.     

Development of two-step radioimmunoassay (RIA) for the measurement of free triiodothyronine in human serum based on antibody coated tubes

Journal of Radioanalytical and Nuclear Chemistry - We describe a simple, user friendly two-step radioimmunoassay (RIA) based on antibody coated tubes for the measurement of free triiodothyronine in...     

STUDIES ON THE EXTRACTION OF SELENIUM AND TELLURIUM FROM COPPER ELECTROLYTIC SLIMES BY SUBLIMATION IN VACUUM

Abstract

Anode slimes obtained from the electrolytic refining of copper contain selenium and tellurium in the form of selenides and tellurides of metals, e.g., copper and silver. The slimes were treated with sulfur under vacuum; selenides and tellurides decomposed to give selenium and tellurium in metallic form which condensed on a cooler zone. Various parameters studied were temperature, time, sulfur addition, briquetting pressure, and fineness of sulfur added. The X-ray diffraction studies carried out on treated and then on untreated slime proved the reaction of sulfur with selenide and telluride of copper to give copper sulfide, selenium, and tellurium. Sulfurization at around 475°C for 60 min gives optimum recoveries.     

Experimental and theoretical assessment of Fe-doped indium-oxide-based dilute magnetic semiconductors

Specimens of iron-doped indium oxide (In_1-xFe_x)₂O₃ with x?=?0.015, 0.03, 0.045 and 0.06, amalgamated through a traditional solid-state reaction method followed by H₂/air sintering, were characterised using an X-ray diffractometer (XRD), a vibrating sample magnetometer (VSM), and a scanning electron microscope (SEM) to investigate their structural, magnetic and morphological properties respectively. According to XRD plots, all the specimens exhibit cubic bixbyite structures along with ancillary phases. Magnetic assessment showed that In₂O₃ has a negative susceptibility, exhibiting diamagnetic behaviour at room temperature. The doping of Fe ions induces ferromagnetic (FM) ordering, which is enhanced with increasing doping content. The strength of the magnetisation increases when the specimens are exposed to H₂ but is reduced on further air sintering. A bound magnetic polaron (BMP) model is successfully fitted to the observed FM data involving localised carriers and magnetic cations. A multivariate assessment viz. a hierarchical cluster analysis (HCA) was used to corroborate and strengthen the experimental determined magnetic properties. A homogeneous particle distribution was observed in all SEM micrographs and is validated through MATLAB-based simulation by applying a watershed segmentation algorithm. Surface plots also confirm the change in magnetic properties with increase in doping concentration.     

The Intensities of f↔f Transitions and Bonding in Fluorinated Lanthanide β-Diketone Chelates

Abstract

Interest in the intensity of lanthanide f?f spectra have begun nearly forty years ago, but most of the work was done after the publication of the theory of lanthanide intensity by Judd¹ and Ofelt² independently in 1962. Since then a number of lanthanide complexes having O-, N- or mixed donor ligands have been studied for the one reason or the other. Various β-diketone chelates were studied^3–7 for the reason that they proved to be good lasing materials. The present communication extends this study further to fluorinated β-diketone chelates of Pr³⁺ and Nd³⁺ which gives useful information regarding interelectronic repulsion, spin-orbit interaction, nephelauxetic effect and bonding in these chelates.     

Trialkyl Acyl Ammonium Halides-A New Series of Phase Transfer Catalysts

Trialkyl acyl ammonium halides have found to be superior phase transfer catalysts. They were easy to prepare and afford the reactions to be carried out at elevated temperature, owing to their stability.