排序方式: 共有26条查询结果,搜索用时 437 毫秒
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O. Anselmino Stone Tollens L. Rosenthaler E. Spaeth Caesar Loretz Panchaud B. Hafner E. W. Mann John Barclay Fromme Fraser Ludwig Krauss P. Lemaire Denigés Kimpflin M. Nussbaum H. Runne C. Guérin G. Denigés Feldhaus Gregor E. Durien Fordos Geélis Utscher C. Gueérin Ernst Deussen E. Beckmann 《Analytical and bioanalytical chemistry》1912,51(10-11):700-712
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Wilh Mühlenfeld Farbenfabriken Elberfeld E. Rupp K. Seegers Padva Savare Caesar und Loretz 《Fresenius' Journal of Analytical Chemistry》1909,48(2):132-134
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Caesar und Loretz 《Fresenius' Journal of Analytical Chemistry》1907,46(12):805
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Caesar und Loretz 《Fresenius' Journal of Analytical Chemistry》1907,46(12):806-807
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Dr. Duy-Khiet Ho Dr. Xabier Murgia Dr. Chiara De Rossi Rebekka Christmann Dr. Antonio G. Hüfner de Mello Martins Dr. Marcus Koch Anastasia Andreas Dr. Jennifer Herrmann Prof. Dr. Rolf Müller Dr. Martin Empting Prof. Dr. Rolf W. Hartmann Dr. Didier Desmaele Dr. Brigitta Loretz Prof. Dr. Patrick Couvreur Prof. Dr. Claus-Michael Lehr 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2020,132(26):10378-10382
Elimination of pulmonary Pseudomonas aeruginosa (PA) infections is challenging to accomplish with antibiotic therapies, mainly due to resistance mechanisms. Quorum sensing inhibitors (QSIs) interfering with biofilm formation can thus complement antibiotics. For simultaneous and improved delivery of both active agents to the infection sites, self-assembling nanoparticles of a newly synthesized squalenyl hydrogen sulfate (SqNPs) were prepared. These nanocarriers allowed for remarkably high loading capacities of hydrophilic antibiotic tobramycin (Tob) and a novel lipophilic QSI at 30 % and circa 10 %, respectively. The drug-loaded SqNPs showed improved biofilm penetration and enhanced efficacy in relevant biological barriers (mucin/human tracheal mucus, biofilm), leading to complete eradication of PA biofilms at circa 16-fold lower Tob concentration than Tob alone. This study offers a viable therapy optimization and invigorates the research and development of QSIs for clinical use. 相似文献