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Caesar Loretz W. Fresenius Grünhut Ch. Blarez Adrian und L. van Itallie 《Fresenius' Journal of Analytical Chemistry》1903,42(3):195-198
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Dandekar P Jain R Stauner T Loretz B Koch M Wenz G Lehr CM 《Macromolecular bioscience》2012,12(2):184-194
A hydrophobic starch derivative is used for safe and enhanced delivery of anticancer agents. The synthesis and characterization of propyl starch with a controlled degree of substitution to modulate the release of the encapsulated hydrophobic drug is reported. The application of this polymer for formulating nanoparticles of docetaxel, an anti-cancer agent effective against numerous types of cancers but possessing intrinsic formulation difficulties is described. The solvent emulsification/diffusion technique is used and the synthesis is optimized with respect to several formulation parameters. Uptake studies with these nanoparticles indicate their enhanced internalization by the cancerous cells and their peri-nuclear localization. 相似文献
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14.
Duy‐Khiet Ho Xabier Murgia Chiara De Rossi Rebekka Christmann Antonio G. Hüfner de Mello Martins Marcus Koch Anastasia Andreas Jennifer Herrmann Rolf Müller Martin Empting Rolf W. Hartmann Didier Desmaele Brigitta Loretz Patrick Couvreur Claus‐Michael Lehr 《Angewandte Chemie (International ed. in English)》2020,59(26):10201-10201
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T. Delphin K. Dieterich G. Weigel L. E. Walbum A. Hellström Caesar Loretz Deer und E. Payet 《Fresenius' Journal of Analytical Chemistry》1908,47(12):785-790
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Caesar und Loretz 《Fresenius' Journal of Analytical Chemistry》1907,46(12):807-808
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17.
By partial condensation the vaporous component of a vapour–gas mixture can be separated. This process plays an important part, especially in the recovery of solvents when the solvent is a vapour and mixed with a gas. The only drawback is, however, the frequent occurrence of undesired fog formation. This fog consists of a large number of small solvent droplets and only by a large effort can it be separated again. Through good modelling of the processes of heat and mass transfer the causes for the formation of fog and a method for its prevention can be found. The solution seems to be paradoxical: to avoid the formation of fog the condenser has to be cooled and heated simultaneously. If fog can be prevented, the degree of separation of the vapour–gas mixture even increases. The heating of the condenser may be accomplished by internal energy recovery, thereby simplifying the apparatus concept and energy supply. 相似文献
18.
M. Loretz R. Coquard E. Maire 《Journal of Quantitative Spectroscopy & Radiative Transfer》2008,109(1):16-27
The aim of this study is to determine the radiative properties, which are the extinction coefficient, the scattering albedo and the scattering phase function, of highly porous open-cell aluminium foam, using more-or-less simple predictive models, and to compare all these models. The radiative properties are predicted using geometric optics laws to model the interaction of radiation with the particles forming the foam. Moreover, the particles forming the foam are large compared with the considered wavelength and are supposed to be sufficiently distant from each other to scatter radiation independently. Thus, the radiative characteristics of the foam can be determined by adding the contributions of each particle. A particular attention is paid on microstructure analysis and modelling. We considered different kinds of cell shapes and struts cross-section, using microscopic and tomographic analysis. Furthermore, a new phase function modelling is presented. Finally, we compare the results of each method with the radiative properties obtained from experimental measurements of directional and hemispherical transmittances and hemispherical reflectance. 相似文献
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Duy‐Khiet Ho Xabier Murgia Chiara De Rossi Rebekka Christmann Antonio G. Hüfner de Mello Martins Marcus Koch Anastasia Andreas Jennifer Herrmann Rolf Müller Martin Empting Rolf W. Hartmann Didier Desmaele Brigitta Loretz Patrick Couvreur Claus‐Michael Lehr 《Angewandte Chemie (International ed. in English)》2020,59(26):10292-10296
Elimination of pulmonary Pseudomonas aeruginosa (PA) infections is challenging to accomplish with antibiotic therapies, mainly due to resistance mechanisms. Quorum sensing inhibitors (QSIs) interfering with biofilm formation can thus complement antibiotics. For simultaneous and improved delivery of both active agents to the infection sites, self‐assembling nanoparticles of a newly synthesized squalenyl hydrogen sulfate (SqNPs) were prepared. These nanocarriers allowed for remarkably high loading capacities of hydrophilic antibiotic tobramycin (Tob) and a novel lipophilic QSI at 30 % and circa 10 %, respectively. The drug‐loaded SqNPs showed improved biofilm penetration and enhanced efficacy in relevant biological barriers (mucin/human tracheal mucus, biofilm), leading to complete eradication of PA biofilms at circa 16‐fold lower Tob concentration than Tob alone. This study offers a viable therapy optimization and invigorates the research and development of QSIs for clinical use. 相似文献