In vitro and in vivo evaluation of a novel anti-EGFR antibody labeled with 89Zr and 177Lu

Journal of Radioanalytical and Nuclear Chemistry - There is an urgent need to develop more specific targeted therapies for lung cancer treatment due to the its low survival rate. EGFR is a...     

Binding and cytotoxicity of 131I-labeled gastrin-releasing peptide receptor antagonists modified by cell penetrating peptides

Gastrin releasing peptide receptors (GRPRs) are one of the most interesting targets over expressed in various tumors. Due to the superior potential of the GRPR antagonist analogs, they have been studied in the tumor radio imaging and therapy field. However, typical antagonists suffered the shortcomings of no internalization and poor binding affinity which hampered their applications in radiotherapy. Therefore, we attempted to introduce Oligoarginines (cell penetrating peptides) to RM26, aiming to increase the binding affinity or even trigger the internalization of the peptides on cells. The results showed Arg₆ as the most potent CPP, significantly enhanced the binding avidity of RM26 to the GRPR.

     

Complexation of 1,3-Diamino-2-hydroxypropane- N,N , N ', N '-tetraacetic Acid (DHPTA) with Heavy Lanthanides (Tb 3+ , Ho 3+ , Lu 3+ ) in Aqueous Solution

Thermodynamic equilibria of complexes of 1,3-diamino-2-hydroxypropane-N,N,N',N'-tetraacetic acid (DHPTA) with heavy lanthanides (Tb3+, Ho3+ and Lu3+) in aqueous solution have been investigated with potentiometry, spectrophotometry, luminescence spectroscopy and nuclear magnetic resonance spectroscopy (NMR). The results identified three 1:1 Ln/DHPTA (Ln: Tb3+, Ho3+ and Lu3+) complexes with different degrees of deprotonation, LnL−, Ln(H−1L)2−, and Ln(OH)(H−1L)3−, where H−1 represents the deprotonation of the hydroxyl group between two methyliminodiacetate groups in the DHPTA structure. The alkoxide form of the DHPTA hydroxyl group directly binds to the lanthanide atom, forming highly strong chelation. The complex of Ln(H−1L)2− could be present as a dimeric or polymeric complex in solution.     

89Zr and 177Lu labeling of anti-DR5 monoclonal antibody for colorectal cancer targeting PET-imaging and radiotherapy

Journal of Radioanalytical and Nuclear Chemistry - Death receptor 5 (DR5) is overexpressed in many tumors. Combination of the anti-DR5 antibody with radionuclides such as lutetium-177 (177Lu) could...     

Invariability of Trivial Extensions of Tilted Algebras Under Stable Equivalences

As a sequel to [8], we investigate here the behaviour of thetrivial extensions of tilted algebras under stable equivalence.It will be shown that if a finite-dimensional symmetric algebra is stably equivalent to the trivial extension of a tilted algebraB, then is the trivial extension of some tilted algebra A whichhas the same type as B.     

On Borcherds type Lie algebras

For each even lattice \({\mathcal L}\), there is a canonical way to construct an infinite-dimensional Lie algebra via lattice vertex operator algebra theory, we call this Lie algebra and its subalgebras the Borcherds type Lie algebras associated to \({\mathcal L}\). In this paper, we apply this construction to even lattices arising from representation theory of finite-dimensional associative algebras. This is motivated by the different realizations of Kac-Moody algebras by Borcherds using lattice vertex operators and by Peng-Xiao using Ringel-Hall algebras respectively. For any finite-dimensional algebra \(A\) of finite global dimension, we associate a Borcherds type Lie algebra \(\mathfrak {BL}(A)\) to \(A\). In contrast to the Ringel-Hall Lie algebra approach, \(\mathfrak {BL}(A)\) only depends on the symmetric Euler form or Tits form but not the full representation theory of \(A\). However, our results show that for certain classes of finite-dimensional algebras whose representation theory is ’controlled’ by the Euler bilinear forms or Tits forms, their Borcherds type Lie algebras do have close relations with the representation theory of these algebras. Beyond the class of hereditary algebras, these algebras include canonical algebras, representation-directed algebras and incidence algebras of finite prinjective types.     

Design of the Intelligent Manipulator Movement Control System Based on the T-S Fuzzy Model

Russian Physics Journal - In the process of controlling the movement of an intelligent manipulator, the control system is interfered by the time delay of the network circuit, which leads to time...     

Triangulated categories and Kac-Moody algebras

By using the Ringel-Hall algebra approach, we find a Lie algebra arising in each triangulated category with T ²=1, where T is the translation functor. In particular, the generic form of the Lie algebras determined by the root categories, the 2-period orbit categories of the derived categories of finite dimensional hereditary associative algebras, gives a realization of all symmetrizable Kac-Moody Lie algebras. Oblatum 4-XII-1998 & 11-XI-1999?Published online: 21 February 2000     

The dimension vectors of indecomposable modules of cluster-tilted algebras and the Fomin-Zelevinsky denominators conjecture

The main result of this paper is that any two non-isomorphic indecomposable modules of a cluster-tilted algebra of finite representation type have different dimension vectors. As an application to cluster algebras of Types A,D,E, we give a proof of the Fomin-Zelevinsky denominators conjecture for cluster variables, namely, different cluster variables have different denominators with respect to any given cluster.