In vitro and in vivo evaluation of a novel anti-EGFR antibody labeled with 89Zr and 177Lu

Journal of Radioanalytical and Nuclear Chemistry - There is an urgent need to develop more specific targeted therapies for lung cancer treatment due to the its low survival rate. EGFR is a...     

室温铁磁性Sr3YCo4O10.5+δ多晶有序化的烧结工艺及电磁性能

采用固相反应法制备了不同烧结温度(950~1 180 ℃)、烧结时间、烧结次数共7种工艺的Sr₃YCo₄O_10.5+δ多晶块材,通过热分析、XRD、SEM确定了有序化相变和最佳烧结工艺(1 180 ℃/24 h+1 180 ℃/24 h),并研究了多晶的电磁性能。结果表明,964 ℃完全晶化的四方相Sr₃YCo₄O_10.5在1 042 ℃吸氧(δ)完成有序化,生成Sr₃YCo₄O_10.5+δ,而1 100 ℃和1 180 ℃烧结的样品均出现(103)、(215)超结构峰,验证了其结构的有序性。块材均呈半导体电输运行为,二次烧结晶格完整性提高,晶粒长大,300 K时电阻率仅为0.06 Ω·cm,居里温度(T_c)~335 K,零场冷曲线(ZFC)上的Hopkinson峰源于低温时被冻结的磁矩随温度升高转向磁场方向,磁化强度在298 K达到最大,随后受热扰动的影响减小。室温铁磁性源于有序结构导致的中自旋或高自旋态Co³⁺的e_g轨道有序。     

Binding and cytotoxicity of 131I-labeled gastrin-releasing peptide receptor antagonists modified by cell penetrating peptides

Gastrin releasing peptide receptors (GRPRs) are one of the most interesting targets over expressed in various tumors. Due to the superior potential of the GRPR antagonist analogs, they have been studied in the tumor radio imaging and therapy field. However, typical antagonists suffered the shortcomings of no internalization and poor binding affinity which hampered their applications in radiotherapy. Therefore, we attempted to introduce Oligoarginines (cell penetrating peptides) to RM26, aiming to increase the binding affinity or even trigger the internalization of the peptides on cells. The results showed Arg₆ as the most potent CPP, significantly enhanced the binding avidity of RM26 to the GRPR.

     

Heavy-traffic limits for an infinite-server fork–join queueing system with dependent and disruptive services

We study an infinite-server fork–join queueing system with dependent services, which experiences alternating renewal service disruptions. Jobs are forked into a fixed number of parallel tasks upon arrival and processed at the corresponding parallel service stations with multiple servers. Synchronization of a job occurs when its parallel tasks are completed, i.e., non-exchangeable. Service times of the parallel tasks of each job can be correlated, having a general continuous joint distribution function, and moreover, the service vectors of consecutive jobs form a stationary dependent sequence satisfying the strong mixing (\(\alpha \)-mixing) condition. The system experiences renewal alternating service disruptions with up and down periods. In each up period, the system operates normally, but in each down period, jobs continue to enter the system, while all the servers will stop working, and services received will be conserved and resume at the beginning of the next up period. We study the impact of both the dependence among service times and these down times upon the service dynamics, the unsynchronized queueing dynamics, and the synchronized process, assuming that the down times are asymptotically negligible. We prove FWLLN and FCLT for these processes, where the limit processes in the FCLT possess a stochastic decomposition property and the convergence requires the Skorohod \(M_1\) topology.     

Excitation Wavelength-Dependent Fluorescence of a Lanthanide Organic Metal Halide Cluster for Anti-Counterfeiting Applications

The achievement of significant photoluminescence (PL) in lanthanide ions (Ln³⁺) has primarily relied on host sensitization, where energy is transferred from the excited host material to the Ln³⁺ ions. However, this luminous mechanism involves only one optical antenna, namely the host material, which limits the accessibility of excitation wavelength-dependent (Ex-De) PL. Consequently, the wider application of Ln³⁺ ions in light-emitting devices is hindered. In this study, we present an organic–inorganic compound, (DMA)₄LnCl₇ (DMA⁺=[CH₃NH₂CH₃]⁺, Ln³⁺=Ce³⁺, Tb³⁺), which serves as an independent host lattice material for efficient Ex-De emission by doping it with trivalent antimony (Sb³⁺). The pristine (DMA)₄LnCl₇ compounds exhibit high luminescence, maintaining the characteristic sharp emission bands of Ln³⁺ and demonstrating a high PL quantum yield of 90–100 %. Upon Sb³⁺ doping, the compound exhibits noticeable Ex-De emission with switchable colors. Through a detailed spectral study, we observe that the prominent energy transfer process observed in traditional host-sensitized systems is absent in these materials. Instead, they exhibit two independent emission centers from Ln³⁺ and Sb³⁺, each displaying distinct features in luminous color and radiative lifetime. These findings open up new possibilities for designing Ex-De emitters based on Ln³⁺ ions.     

求弹性半平面问题基本解的一个新方法

本文所提到的弹性半平面问题的基本解是一个满足特殊条件的弹性半平面的应力位移解答。这些条件为:(1)半平面内一点处作用有集中力X,Y或集中力偶M;(2)半平面边界为自由或固定边。利用平面弹性的复变函数方法,文中把弹性半平面基本解的问题归结为下列问题,使一个特定解析函数和另一个解析函数的共轭值在半平面边界上相等。对上述转化后的问题,只要利用复变函数的性质,不难从基本解的第一部分推导出基本解的第二部分。其中,基本解的第一部分是弹性全平面的本基解。从而,半平面问题基本解可以方便地得到。此外,文中还首次给出了:(1)集中力偶作用于半平面内一点时的基本解;(2)当半平面边界固定情况下的基本解。     

材料破坏过程中应力分布的数值光弹图

 介绍应用材料破坏过程分析(MFPA)系统进行材料破坏过程应力 场分析的“数值光弹”方法. 给出了几种材料试样在外部载荷作用 下变形或破坏时的内部应力分布条纹图. 结果表明(MFPA)系统为研 究材料破坏过程中的应力分布提供了一种简单易行的分析方法.     

Ultrathin two-dimensional MnO2 nanosheet as a stable coreactant of 3,3′,5,5′-tetramethylbenzidine chromogenic substrate for visual and colorimetric detection of iron(II) ion

Microchimica Acta - The authors report on a chromogenic system based MnO2 nanosheet and the chomgenic substrate 3,3′,5,5′-tetramethylbenzidine (TMB). The MnO2 nanosheet can oxidize TMB...     

89Zr and 177Lu labeling of anti-DR5 monoclonal antibody for colorectal cancer targeting PET-imaging and radiotherapy

Journal of Radioanalytical and Nuclear Chemistry - Death receptor 5 (DR5) is overexpressed in many tumors. Combination of the anti-DR5 antibody with radionuclides such as lutetium-177 (177Lu) could...