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Bumagin Nikolay A. Petkevich Sergey K. Kletskov Alexey V. Alekseyev Roman S. Potkin Vladimir I. 《Chemistry of Heterocyclic Compounds》2019,55(6):508-516
Chemistry of Heterocyclic Compounds - N-(4,6-Dimethylpyrimidin-2-yl)-5-phenylisoxazole-3-carboxamide was used as a ligand for obtaining bimetallic boron-containing heterogeneous catalysts... 相似文献
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V. I. Potkin S. K. Petkevich A. V. Kletskov E. A. Dikusar Yu. S. Zubenko N. A. Zhukovskaya V. V. Kazbanov S. G. Pashkevich 《Russian Journal of Organic Chemistry》2013,49(10):1523-1533
Acylation of benzene and toluene with 5-phenyl- and 5-(p-tolyl)isoxazole-3-carbonyl chlorides gave 5-phenyl(or p-tolyl)isoxazol-3-yl phenyl(or p-tolyl)ketones which were reduced to the corresponding alcohols with sodium tetrahydridoborate in propan-2-ol. Selective reduction of the carboxy group in 4,5-dichloroisothiazole-3-carboxylic acid was achieved by the action of BH3, and the aldehyde group in 4-formyl-2-methoxyphenyl 5-arylisoxazole-3-carboxylates and 4,5-dichloroisothiazole-3-carboxylates was reduced to hydroxymethyl group with sodium triacetoxyhydridoborate in benzene. Acylation of the resulting hydroxymethyl derivatives with 5-arylisoxazole- and 4,5-dichloroisothiazole-3-carbonyl chlorides afforded the corresponding esters containing two azole fragments in their molecules. 相似文献
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S. K. Petkevich E. A. Dikusar A. V. Kletskov I. B. Rozenzveig G. G. Levkovskaya P. V. Kurman R. M. Zolotar’ V. I. Potkin 《Russian Journal of General Chemistry》2018,88(2):234-240
Alkylation of fluorophenols and phenolic aldehydes with 5-phenyl(p-tolyl)-3-chloromethylisoxazole under the Williamson reaction conditions afforded the corresponding ethers. Condensation of the resulting phenolic aldehyde derivatives and 5-phenyl(p-tolyl)isoxazole-3-carbaldehydes with p-fluoroaniline resulted in fluorine-containing azomethines. Acylation of fluorinated amines with 5-(p-tolyl)isoxazole- and 4,5- dichloroisothiazole-3-carbonyl chlorides gave rise to fluorinated amides bearing isoxazole and isothiazole fragments, representatives of which showed a synergistic effect in compositions with insecticides. 相似文献
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Dmitrii Semenok Alexey Kletskov Evgenij Dikusar Vladimir Potkin Oleg Lukin 《Tetrahedron letters》2018,59(4):372-374
A library of 4′-chloro- and 4′-fluorosulfonyl-substituted chalcones was prepared via the aldol-type condensation reactions of 4-acetylbenzene-1-sulfonyl halides with various aromatic aldehydes, either in absolute ethanol or glacial acetic acid, in the presence of dry HCl. This represents the first examples of chalcone sulfonyl halides in which the phenone ring bears one of these functional groups. The reactivity of the chalcone sulfonyl halides were strongly dependent on the styrene ring substituents; sulfonyl chlorides reacted with most nucleophiles (e.g. amines, alcohols), while sulfonyl fluorides reacted only with charged nucleophiles (e.g. phenolates). 相似文献
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V. I. Potkin N. A. Bumagin A. V. Kletskov S. K. Petkevich P. V. Kurman 《Russian Journal of Organic Chemistry》2016,52(11):1661-1669
From (4,5-dichloroisothiazol-3-yl)phenylmethanol by Ritter reaction a substituted acetamide was synthesized that at hydrolysis with HCl afforded (4,5-dichloroisothiazol-3-yl)phenylmethylamine hydrochloride. By reaction of (5-arylisoxazol-3-yl)- and 4,5-dichloroisothiazol-3-yl)arylmethanol with thionyl chloride the corresponding (1,2-azol-3-yl)arylchloromethanes were obtained. At treatment with O- and N-nucleophiles chlorine atom in chloromethylеne fragment of obtained compounds was substituted by residues of benzylamine, morpholine, vanillin, and ethoxy group. 相似文献
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E. A. Dikusar V. I. Potkin T. D. Zvereva N. A. Zhukovskaya Yu. S. Zubenko A. V. Kletskov R. M. Zolotar’ O. P. Chepik 《Russian Journal of General Chemistry》2012,82(9):1537-1539
Condensation of substituted benzaldehydes of the vanillin series with propane-1,2-diol and 3-chloropropane-1,2-diol in boiling benzene in the presence of FIBAN K-1 sulfonated cation exchanger as catalyst gave the corresponding substituted 1,3-dioxolanes. 相似文献
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E. A. Dikusar S. K. Petkevich A. V. Kletskov T. D. Zvereva N. A. Zhukovskaya R. A. Gadzhily A. G. Aliev G. M. Mamedova Sh. F. Nagieva V. I. Potkin 《Russian Journal of Organic Chemistry》2018,54(1):87-94
The condensation of ethyl 4-(chloromethyl)-2,6-dimethylpyridine-3-carboxylate with substituted phenols in ethanol in the presence of potassium carbonate afforded the corresponding aryl pyridin-4-ylmethyl ethers. Analogous condensation with substituted anilines gave 2-aryl-4,6-dimethyl-1,2-dihydropyrrolo[3,4-c]- pyridin-3-ones. Esters containing 1,2-azole fragments were synthesized by acylation of hydroxymethylsubstituted ethers with 5-arylisoxazole- and 4,5-dichloroisothiazole-3-carbonyl chlorides. 相似文献
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V.?I.?PotkinEmail author S.?K.?Petkevich A.?V.?Kletskov I.?A.?Kolesnik E.?A.?Dikusar I.?B.?Rozentsveig G.?G.?Levkovskaya D.?K.?Nasirova K.?K.?Borisova F.?I.?Zubkov 《Russian Journal of Organic Chemistry》2018,54(3):452-462
The reduction of acetylcymantrene with sodium tetrahydridoborate gave cymantrenylethanol which was acylated with 4,5-dichloroisothiazole- and 5-(4-methylphenyl)isoxazole-3-carbonyl chlorides to obtain esters containing a 1,2-thia(oxa)zole fragment. The condensation of acetylcymantrene with 5-arylisoxazole-3- carbaldehydes, (5-arylisoxazol-3-yl)methoxybenzaldehydes (Ar = Ph, 4-Tol), and 4,5-dichloroisothiazole-3- carbaldehyde afforded the corresponding (E)-3-(azol-3-yl)-1-cymantrenylprop-2-en-1-ones. The resulting α,β- unsaturated ketones reacted with semicarbazide hydrochloride and thiosemicarbazide to produce substituted 4,5-dihydro-1H-pyrazole-1-carboxamides and -1-carbothioamides, and their reaction with hydroxylamine hydrochloride led to the formation of 4,5-dihydroisoxazoles containing cymantrene and 1,2-azole fragments. Heterocyclization of azolylcymantrenylpropenones with guanidine gave 2-aminopyrimidine derivatives, and dihydropyrimidine-2-thiones were obtained by their reaction with thiourea. 相似文献
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S. K. Petkevich A. S. Kishkentaeva O. G. Ryazantsev E. A. Dikusar N. A. Zhukovskaya A. V. Kletskov N. G. Kozlov G. A. Atazhanova S. M. Adekenov V. I. Potkin S. G. Pashkevich A. A. Denisov V. A. Kul’chitskii 《Russian Journal of Organic Chemistry》2014,50(9):1351-1356
Esters derived from 5-phenyl-, 5-(4-methylphenyl)-, and 5-(2,5-dimethylphenyl)-1,2-oxazole-3-carboxylic and 4,5-dichloro-1,2-thiazole-3-carboxylic acids and some natural alcohols (L-menthol, grosshemin), thymol, and synthetic analogs of the latter (4-tert-butylphenol, 4-tert-octylphenol, 2-tert-butyl-4-methylphenol) were synthesized by reactions of the corresponding alcohols with acid chlorides. 相似文献