Synthesis of Fluorine-Containing Derivatives of 5-Arylisoxazoles and 4,5-Dichlorothiazole |
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| Authors: | S K Petkevich E A Dikusar A V Kletskov I B Rozenzveig G G Levkovskaya P V Kurman R M Zolotar’ V I Potkin |
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| Institution: | 1.Institute of Physical Organic Chemistry,National Academy of Sciences of Belarus,Minsk,Belarus;2.Favorskii Irkutsk Institute of Chemistry, Siberian Branch,Russian Academy of Sciences,Irkutsk,Russia;3.Institute of Bioorganic Chemistry,National Academy of Sciences of Belarus,Minsk,Belarus |
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| Abstract: | Alkylation of fluorophenols and phenolic aldehydes with 5-phenyl(p-tolyl)-3-chloromethylisoxazole under the Williamson reaction conditions afforded the corresponding ethers. Condensation of the resulting phenolic aldehyde derivatives and 5-phenyl(p-tolyl)isoxazole-3-carbaldehydes with p-fluoroaniline resulted in fluorine-containing azomethines. Acylation of fluorinated amines with 5-(p-tolyl)isoxazole- and 4,5- dichloroisothiazole-3-carbonyl chlorides gave rise to fluorinated amides bearing isoxazole and isothiazole fragments, representatives of which showed a synergistic effect in compositions with insecticides. |
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