Phthalocyanine-aniline dyad constructed with click electrochemistry: a novel hybrid electrochromic material

Journal of Solid State Electrochemistry - A novel hybrid electrochromic material, dyad of poly 4-azidoaniline (PANI-N3) and manganese phthalocyanine bearing terminal alkynyl moieties (TA-MnPc), was...     

A new ternary Cu (II) complex with 4,7-dimethyl-1,10-phenanthroline and NOO-type tridentate Schiff base ligand: Synthesis,crystal structure,biomacromolecular interactions,and radical scavenging activities

NOO-type tridentate Schiff base, N-salicylidene-2-aminobenzoic acid, (H₂L), and its ternary Cu (II) complex containing H₂L Schiff base and 4,7-dimethyl-1,10-phenanthroline (4,7-dmphen), [Cu(4,7-dmphen)(H₂L)]₂7H₂O, have been synthesized and characterized by CHN analysis, ESI-MS, FTIR, and single-crystal X-ray diffraction techniques. The interaction of alone H₂L Schiff base ligand and ternary Cu (II) complex with biomacramolecules {calf thymus DNA (CT-DNA) and bovine serum albumin (BSA)} has been investigated by electronic absorption and fluorescence spectroscopy. The experimental results indicate that H₂L Schiff base ligand and ternary Cu (II) complex bind to CT-DNA by means of a moderate intercalation mode. Furthermore, the fluorescence quenching mechanism between H₂L Schiff base ligand and ternary Cu (II) complex with BSA possesses a static quenching process. Radical scavenging activity of H₂L Schiff base ligand and ternary Cu (II) complex was measured in terms of EC₅₀, using the DPPH and H₂O₂ methods. Biomacromolecule interactions and scavenging activity studies revealed that ternary Cu (II) complex yielded better results than H₂L Schiff base ligand alone.     

Anodic Voltammetric Determination of an Atypical Antipsychotic Drug Amisulphide in Pharmaceutical Dosage Forms Using Electrochemical fsDNA Biosensor

Russian Journal of Electrochemistry - In this study, a new biosensor for amisulpride (ASP) determination is defined. The interaction between ASP and fish sperm double-stranded DNA (FSdsDNA) was...     

Enamines of 1,3-dimethylbarbiturates and their symmetrical palladium(II) complexes: synthesis,characterization and biological activity

Transition Metal Chemistry - Three 1,3-dimethylbarbiturate-enamine derivatives and their symmetrical palladium(II) complexes were prepared and characterized by spectroscopic methods. In addition,...     

Effect of Operating Conditions in Production of Diagnostic Salmonella Enteritidis O-Antigen-Specific Monoclonal Antibody in Different Bioreactor Systems

In this study, different cultivation systems such as roller bottles (RB), 5-L stirred-tank bioreactor (STR), and disposable bioreactors were used to cultivate hybridoma for lab-scale production of Salmonella Enteritidis O-antigen-specific monoclonal antibody (MAb). Hybridoma cell line was cultivated in either serum-containing or serum-free medium (SFM) culture conditions. In STR, MAb production scaled up to 4 L, and production capabilities of the cells were also evaluated in different featured production systems. Moreover, the growth parameters of the cells in all production systems such as glucose consumption, lactate and ammonia production, and also MAb productivities were determined. Collected supernatants from the reactors were concentrated by a cross-flow filtration system. In conclusion, cells were not adapted to SFM in RB and STR. Therefore, less MAb titer in both STR and RB systems with SFM was observed compared to the cultures containing fetal bovine serum-supplemented medium. A higher MAb titer was gained in the membrane-aerated system compared to those in STR and RB. Although the highest MAb titer was obtained in the static membrane bioreactor system, the highest productivity was obtained in STR operated in semicontinuous mode with overlay aeration.     

Synthesis and evaluations of bisphosphonate‐containing monomers for dental materials

Two new bismethacrylamide ( 1 , 2 ) and two new methacrylamide ( 3 , 4 ) dental monomers were synthesized. In each group, one monomer contains a bisphosphonate group, the other a bisphosphonic acid group. Monomer 1 and 3 were synthesized by amidation of 2‐(2‐chlorocarbonyl‐allyloxymethyl)‐acryloylchloride and methacryloyl chloride with tetraethyl aminomethyl‐bis(phosphonate) and converted to the bisphosphonic acid monomers 2 and 4 by hydrolysis with trimethylsilyl bromide. Monomer 1 (m.p.: 71–72 °C), monomer 3 ( 33–34 °C), and monomer 4 (no m.p.) were obtained as white solids and monomer 2 a viscous liquid, soluble in water. Homopolymerization of 1 gave crosslinked polymers, indicating its low cyclization tendency. The photopolymerization studies indicated that its copolymerizability with 2,2‐bis[4‐(2‐hydroxy‐3‐methacryloyloxy propyloxy) phenyl] propane and 2‐hydroxyethyl methacrylate (HEMA) without changing their rates and conversions significantly means that it could be used as a biocompatible crosslinker. Although monomer 2 showed low polymerizability, because of its good performance in terms of solubility, hydrolytic stability, hydroxyapatite interaction, acidity, and copolymerizability with HEMA, it shows potential to be used in self‐etching dental adhesives. The thermal polymerization of 3 resulted in soluble polymers and evaluation of monomer 4 in terms of solubility, acidity, and copolymerizability with HEMA indicated its potential as an adhesive monomer. © 2012 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2012     

New chiral ruthenium(II)–phosphinite complexes containing a ferrocenyl group in enantioselective transfer hydrogenations of aromatic ketones

A new and versatile class of unsymmetrical ferrocenyl-phosphinite ligands possessing a stereogenic center has been prepared from commercially available, inexpensive aminoacids such as, d-, l-phenylglycine and d-, l-phenylalanine, through a concise synthetic procedure. These ligands are not very sensitive to air and moisture, and display good enantioselectivities in the ruthenium-catalyzed asymmetric transfer hydrogenation of acetophenone derivatives, in which up to 91% ee was obtained. A comparison of the catalytic properties of amino alcohols and other analogues based on a ferrocenyl backbone is also discussed briefly. The structures of these ligands and their corresponding complexes have been elucidated by a combination of multinuclear NMR spectroscopy, IR spectroscopy, and elemental analysis.     

Characterization and kinetics analysis of the thermal decomposition of the humic substance from hazelnut husk

A humic substance was obtained from hazelnut husk using an alkali extraction. The chemical and morphological structure of the humic matter was characterized via elemental analysis, Fourier transform infrared spectrometry (FTIR), nuclear magnetic resonance, Brunauer-Emmet-Teller (BET) analysis, scanning electron microscopy (SEM), and thermogravimetric-FTIR (TG-FTIR). In addition, thermal analysis measurements TG analysis-differential thermogravimetry/differential scanning calorimetry (TGA-DTG/DSC) were performed under dynamic air conditions to better determine the origin, physical and chemical structure, and decomposition process of the humic matter. The Kissinger-Akahira-Sunose (KAS) and Flynn-Wall-Ozawa (FWO) methods were used to calculate the kinetic parameters of the high-temperature decomposition process. It was observed that the activation energy values were almost constant at certain conversion and temperature intervals. In addition, the structure of the humic substance at different temperatures was also investigated via FTIR analysis. It was found that the obtained humic substance had a very stable structure and decomposed at a high temperature. The stability of the humic matter can be a useful tool in the environmental quality research of soil.