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1.
Investigating microfluidic flow profiles is of interest in the microfluidics field for the determination of various characteristics of a lab-on-a-chip system. Microparticle tracking velocimetry uses computational methods upon recording video footage of microfluidic flow to ultimately visualize motion within a microfluidic system across all frames of a video. Current methods are computationally expensive or require extensive instrumentation. A computational method suited to microparticle tracking applications is the robust Kanade–Lucas–Tomasi (KLT) feature-tracking algorithm. This work explores a microparticle tracking velocimetry program using the KLT feature-tracking algorithm. The developed program is demonstrated using pressure-driven and EOF and compared with the respective mathematical fluid flow models. An electrostatics analysis of EOF conditions is performed in the development of the mathematical using a Poisson's Equation solver. This analysis is used to quantify the zeta potential of the electroosmotic system. Overall, the KLT feature-tracking algorithm presented in this work proved to be highly reliable and computationally efficient for investigations of pressure-driven and EOF in a microfluidic system. 相似文献
2.
Michael Appell Kervin O. Evans David L. Compton Lijuan C. Wang Wayne B. Bosma 《Structural chemistry》2018,29(3):715-723
A time-dependent density functional theory (TD-DFT) study was carried out on tautomers of the mycotoxin citrinin in the neutral, anionic, and cationic forms to gain insight into the role of chemical structure on detection. Steady-state fluorescence studies of citrinin in micellar aqueous solutions produced unusual results for ionic surfactants and the neutral Triton X-100 enhanced fluorescence emission. Ground-state and time-dependent density functional studies were carried out on five tautomers of citrinin using the B3LYP density functional and the 6-311+G(2df,2p) basis set. The investigation revealed that deprotonation is a major factor governing the shifts in fluorescence excitation and emission maxima. Moreover, the position of the lowest unoccupied molecular orbitals is removed from the fluorophore moiety of citrinin in the dianionic state which is consistent with the diminished fluorescence of the toxin in basic solutions. The ionic characteristics of certain chemosensors can influence the structure and intrinsic spectroscopic properties of citrinin. 相似文献
3.
Daniel R. Zuidema Sarah L. Williams Katherine J. Wert Karin J. Bosma Abigail L. Smith Robert C. Mebane 《合成通讯》2013,43(19):2927-2931
Aryl ketones are readily deoxygenated to their corresponding aryl alkanes upon treatment with Raney nickel catalyst in boiling 2-propanol.
4.
John W.Grove 《数学物理学报(B辑英文版)》2010,30(2):563-594
This article describes mathematical models for phase separated mixtures of materials that are in pressure and velocity equilibrium but not necessarily temperature equilibrium. General conditions for constitutive models for such mixtures that exhibit a single mixture sound speed are discussed and specific examples are described. 相似文献
5.
CM Thaker S Rayaprol Krushna Mavani DS Rana MS Sahasrabudhe SI Patil DG Kuberkar 《Pramana》2002,58(5-6):1035-1039
The effect of simultaneous substitution of a fluctuating cation and a divalent cation in LaMnO3 perovskite modifies the properties of the material to exhibit large valence colossal magnetoresistance (CMR) effect. A good
example of these properties is (La1−2x
Pr
x
Ca
x
)MnO3 (LPCMO) type CMR material. In this communication it is reported that, with the increase in x (for x=0.1, 0.15, 0.2), the T
c varies between 100 and 120 K with improvisation in metal-insulator transition. Interestingly, resistance increases with x from few hundred ohms to few kilo ohms with corresponding decrease in the unit cell volume. The results of the studies using
X-ray diffraction (XRD), electrical resistivity, magnetoresistance and ac susceptibility measurements on LPCMO samples for
understanding the structural, transport and magnetic properties are discussed in detail. 相似文献
6.
H. Bosma 《Applied Scientific Research》1958,7(1):131-144
Summary The behaviour of two capacitive windows in a rectangular wave guide, located at small distances apart in comparison with the wave length, is investigated. The three-dimensional problem is reduced to a two-dimensional one. Two simultaneous integral equations for the electric field intensities in the apertures are derived. A solution for these unknown quantities can be obtained, representing them by a Fourier series and approximating the kernel functions. Expressions for the reflection and transmission coefficients are given. Absolute values of the transmission coefficient are obtained, both theoretically and experimentally. 相似文献
7.
Boersma YL Pijning T Bosma MS van der Sloot AM Godinho LF Dröge MJ Winter RT van Pouderoyen G Dijkstra BW Quax WJ 《Chemistry & biology》2008,15(8):782-789
Lipases are successfully applied in enantioselective biocatalysis. Most lipases contain a lid domain controlling access to the active site, but Bacillus subtilis Lipase A (LipA) is a notable exception: its active site is solvent exposed. To improve the enantioselectivity of LipA in the kinetic resolution of 1,2-O-isopropylidene-sn-glycerol (IPG) esters, we replaced a loop near the active-site entrance by longer loops originating from Fusarium solani cutinase and Penicillium purpurogenum acetylxylan esterase, thereby aiming to increase the interaction surface for the substrate. The resulting loop hybrids showed enantioselectivities inverted toward the desired enantiomer of IPG. The acetylxylan esterase-derived variant showed an inversion in enantiomeric excess (ee) from -12.9% to +6.0%, whereas the cutinase-derived variant was improved to an ee of +26.5%. The enantioselectivity of the cutinase-derived variant was further improved by directed evolution to an ee of +57.4%. 相似文献
8.
A pheromone from the beetle, Galerucella calmariensis, was recently isolated and identified (Bartelt, R. J. et al. J. Chem. Ecol. 2006, 32, 693-712) as a 14-carbon, bicyclic dimethylfuran lactone, with the systematic name 12,13-dimethyl-5,14-dioxabicyclo[9.2.1]tetradeca-1(13),11-dien-4-one. The main 12-membered lactone ring is very flexible; as a result, there exist multiple possible conformations. The preferred conformation cannot be deduced solely from room-temperature NMR measurements. Using density functional (DFT) studies, 26 unique conformers with energies within 10.0 kcal/mol of the global minimum-energy structure were found. A mirror-image plane exists so that each conformer has an "inverse" structure with the same energy, for which the dihedral angles around the flexible ring have opposite sign. The isotropic 1H and 13C NMR chemical shifts of the DFT-optimized structures were calculated using the gauge-including atomic orbital (GIAO) method. By considering the relative energies of the conformers and the calculated and observed NMR spectra, we concluded that the molecule exists primarily as a mixture of two distinct conformers at room temperature, each being present with its mirror-image inverse. Structural interconversions among these likely occur on a time scale that is fast compared to the NMR experiments. Using mode-following and dihedral-driving techniques, several potential pathways were found for the conversion of the lowest-energy conformer to its mirror-image structure. Ab initio molecular dynamics (AIMD) using the 4-31G basis set was carried out for 50 ps to test the availability of various low-energy minima and the transition states found from the searches noted above. 相似文献
9.
In order to study the density of the set of positive integers for which the negative Pell equation is solvable in integers, we compute the norm of the fundamental unit in certain well-chosen families of real quadratic orders. A fast algorithm that computes 2-class groups rather than units is used. It is random polynomial-time in as the factorization of is a natural part of the input for the values of we encounter. The data obtained provide convincing numerical evidence for the density heuristics for the negative Pell equation proposed by the second author. In particular, an irrational proportion of the real quadratic fields without discriminantal prime divisors congruent to 3 mod 4 should have a fundamental unit of norm .
10.