黄酮-6-羧酸类化合物的合成、表征和抑菌活性

通过查尔酮路线合成了6种黄酮-6-羧酸化合物,采用I2/DMSO为氧化剂通过微波辐射合成了其中3种黄酮羧酸.所有化合物的结构通过NMR,IR和元素分析方法进行了表征,并采用X射线单晶衍射法进一步测定了黄酮-6,4'-二羧酸的晶体结构.初步生物活性试验结果表明,6种化合物对大肠杆菌、金黄色葡萄球菌和枯草芽孢杆菌均有一定的抑制作用.     

Characterization and Infrared Stealthy Properties of Two Schiff-base Compounds Derived from 1-Amino-2-hydroxypropane and Their Complexes

Single crystals of two Schiff base compounds 1 and 2 derived from 1-amino-2-hydroxypropane were obtained via condensation reaction of an amine and a reactive carbonyl group. The compounds were characterized by elemental analysis, IR and single-crystal X-ray diffraction. Compound 1(C(10)H(13)NO2) crystallizes in the monoclinic system, space group P21 with a = 4.487(9), b = 10.913(2), c = 9.886(19) ?, β = 97.823(3)o, V = 479.59(16) ?~3, Z = 2, Mr = 179.21, Dc = 1.241 g/cm^3, F(000) = 192, GOOF = 1.005, μ = 0.087 mm^-1, the final R = 0.0328 and wR = 0.0738 for 1721 observed reflections with I > 2σ(I). Compound 2(C(14)H(20)N2O2) crystallizes in orthorhombic system, space group Pbca with a = 6.295(2), b = 7.290(3), c = 30.519(11) ?, V = 1400.5(9)?~3, Z = 8, Mr = 248.32, Dc = 1.178 g/cm^3, F(000) = 536, GOOF = 1.125, μ = 0.079 mm^-1, the final R = 0.0871 and w R = 0.1748 for 1307 observed reflections with I > 2σ(I). Compound 1 exhibits a 3D supramolecular structure and compound 2 show a 3D supramolecular structure under hydrogen bonding interactions. Furthermore, the infrared stealthy performance of two Schiff base compounds and their Fe(Ⅲ) complexes were studied. The results show that their Fe(Ⅲ) complexes show lower infrared emissivity than corresponding Schiff base compounds, and the lowest infrared emissivity reaches to 0.657.