First Synthesis of Mosquito Larvicidal Butenolides I and II

ＩｎｔｒｏｄｕｃｔｉｏｎＶｅｒｙｒｅｃｅｎｔｌｙ ,ｔｗｏｎｅｗｍｏｓｑｕｉｔｏｌａｒｖｉｃｉｄａｌｂｕｔｅｎｏ ｌｉｄｅｓＩ (1)ａｎｄＩＩ (2 )ｗｅｒｅｉｓｏｌａｔｅｄｂｙＫａｒｕｎａｒａｔｎｅｅｔａｌ.1ｆｒｏｍｔｈｅｌｅａｖｅｓｏｆａｌｌｔｈｒｅｅｓｐｅｃｉｅｓｏｆＨｏｒｔｏｎｉａ (ｆａｍ ｉｌｙＭｏｎｉｍｉａｃｅａｅ) (Ｈ .ａｎｇｕｓｔｉｆｏｌｉａ ,Ｈ .ｆｌｏｒｉｂｕｎｄａａｎｄＨ .ｏｖａｌｉｆｏｌｉａ) .Ｂｏｔｈｂｕｔｅｎｏｌｉｄｅｓｅｘｈｉｂｉｔｅｄｍｏｓｑｕｉｔｏｌａｒ ｖｉｃｉｄａｌａｃｔ…     

两个具有PTP1B抑制活性的4-羟基丁内酯化合物的全合成研究

Two new naturally 4-hydroxylated butenolides were concisely synthesized in excellent enantiomeric purities. An aldol condensation and a Suzuki reaction served successfully as the key steps in the synthesis.     

Synthesis of a Mimicking Hybrid of Annonaceous Acetogenin with Steroid for Antitumoral Activity Investigation

ＩｎｔｒｏｄｕｃｔｉｏｎＩｎｔｈｅｐａｓｔｔｗｏｄｅｃａｄｅｓ ,ａｌａｒｇｅｆａｍｉｌｙｏｆｎａｔｕｒａｌｐｒｏｄｕｃｔｓｎａｍｅｄａｎｎｏｎａｃｅｏｕｓａｃｅｔｏｇｅｎｉｎｓｗｅｒｅｉｓｏｌａｔｅｄａｎｄｃｈａｒａｃｔｅｒｉｚｅｄｂｙｔｈｅｇｌｏｂａｌｒｅｓｅａｒｃｈｅｒｓｆｒｏｍｖａｒｉｏｕｓｓｐｅｃｉｅｓｏｆｔｈｅｐｌａｎｔａｎｎｏｎａｅａｅ .1Ａｍｏｎｇｏｖｅｒ 4 0 0ｍｅｍ ｂｅｒｓ,ｍｏｓｔｏｆｔｈｅｍｗｅｒｅｆｏｕｎｄｔｏｓｈｏｗｐｏｔｅｎｔｃｙｔｏｔｏｘｉｃａｎｄａｎｔｉｔｕｍｏｒａ…     

3-[(Z)-十五碳-8-烯基]儿茶酚的全合成及其抗肿瘤血管生成活性研究

以2,3-二甲氧基苯甲醛为原料,经过Barbier偶联反应,将邻二酚羟基的保护基从甲基保护转换成缩丙酮保护,再经Wittig反应等方法合成了3-[(Z)-十五碳-8-烯基]儿茶酚(GQ-5).所合成化合物的结构均经1H NMR,13C NMR及MS(HRMS)进行了鉴定.采用人脐静脉内皮细胞株对GQ-5的抗肿瘤血管生成活性进行了评价.