Structure and Performance Modulation of Self-Adhesive SIS/C5 Electrospun Membranes for Transdermal Drug Delivery北大核心CSCD

Electrospun membranes are widely utilized to enhance the water vapor permeability and drug delivery performance of transdermal drug delivery patches. Due to the lack of adhesion property,however,most of them cannot closely contact with skin,which impedes the delivery of drugs to the skin,thus affecting the transdermal administration. C5 resin is used to endow poly（styrene isoprene styrene）（SIS）electrospun membranes with pressure-sensitive adhesion property. Investigation is performed on how to control the structure,adhesion properties and drug delivery performance of SIS/C5 electrospun membranes loaded with synthetic capsaicin via compositions,drugs and electrospinning conditions. The results demonstrate that the electrospun membrane with a SIS/C5 ratio of 2∶1 has excellent water vapor permeability（7. 17×10－3 g/（h·cm2）and adhesion properties（180（°）peel strength is 0. 2 kN/m,tack force is 0. 64 N/cm2 ,holding power is greater than 7 days）. The synthetic capsaicin has good compatibility with the SIS/C5 electrospun membranes,in which no drug crystallizes and the drug loading is beneficial to improve the water vapor permeability. As the drug loading is 8%,the tack force is 0. 6～0. 8 N/cm2 ,the 180（°）peel strength is 0. 2～0. 3 kN/m,the holding power is greater than 7 days,and no residue is left during peeling tests. In vitro drug release indicates that the drug has a behavior of sustained release with a 24-hour cumulative release rate of greater than 50% for all SIS/ C5 electrospun membranes,meeting the requirements of transdermal drug delivery patches. © 2022, Science Press (China). All rights reserved.     

Tetrapartite entanglement measures of generalized GHZ state in the noninertial frames

Using a single-mode approximation, we carry out the entanglement measures, e.g., the negativity and von Neumann entropy when a tetrapartite generalized GHZ state is treated in a noninertial frame, but only uniform acceleration is considered for simplicity. In terms of explicit negativity calculated, we notice that the difference between the algebraic average $\pi_{4}$ and geometric average $\varPi_{4}$ is very small with the increasing accelerated observers and they are totally equal when all four qubits are accelerated simultaneously. The entanglement properties are discussed from one accelerated observer to all four accelerated observers. It is shown that the entanglement still exists even if the acceleration parameter $r$ goes to infinity. It is interesting to discover that all 1-1 tangles are equal to zero, but 1-3 and 2-2 tangles always decrease when the acceleration parameter $r$ increases. We also study the von Neumann entropy and find that it increases with the number of the accelerated observers. In addition, we find that the von Neumann entropy $S_{\text{ABCDI}}$, $S_{\text{ABCIDI}}$, $S_{\text{ABICIDI}}$ and $S_{\text{AIBICIDI}}$ always decrease with the controllable angle $\theta$, while the entropies $S_{3-3~\rm non}$, $S_{3-2~\rm non}$, $S_{3-1~\rm non}$ and $S_{3-0~\rm non}$ first increase with the angle $\theta$ and then decrease with it.     

Tripartite Entanglement Measures of Generalized GHZ State in Uniform Acceleration

Using the single-mode approximation,we study entanglement measures including two independent quantities;i.e.,negativity and von Neumann entropy for a tripartite generalized Greenberger-Horne-Zeilinger(GHZ)state in noninertial frames.Based on the calculated negativity,we study the whole entanglement measures named as the algebraic average π3-tangle and geometric average Π3-tangle.We find that the difference between them is very small or disappears with the increase of the number of accelerated qubits.The entanglement properties are discussed from one accelerated observer and others remaining stationary to all three accelerated observers.The results show that there will always exist entanglement,even if acceleration r arrives to infinity.The degree of entanglement for all 1-1 tangles are alwa.ys equal to zero,but 1-2 tangles always decrease with the acceleration parameter r.We notice that the von Neumann entropy increases with the number of the accelerated observers and Sκ_Ιζ_Ι(κ,ζ∈(A,B,C)) first increases and then decreases with the acceleration parameter r.This implies that the subsystem ρκΙζΙ is first more disorder and then the disorder will be reduced as the acceleration parameter r increases.Moreover,it is found that the von Neumann entropies SABCI,SABICI and SAIBICI always decrease with the controllable angle θ,while the entropies of the bipartite subsystems S2-2_(non)(two accelerated qubits),S2-1_(non)(one accelerated qubit) and S2-0_(non)(without accelerated qubit) first increase with the angle θ and then decrease with it.     

Semi-exact Solutions of Konwent Potential

In this work we study the quantum system with the symmetric Konwent potential and show how to find its exact solutions. We find that the solutions are given by the confluent Heun function. The eigenvalues have to be calculated numerically because series expansion method does not work due to the variable z ≥ 1. The properties of the wave functions depending on the potential parameter A are illustrated for given potential parameters V_0 and a. The wave functions are shrunk towards the origin with the increasing |A|. In particular, the amplitude of wave function of the second excited state moves towards the origin when the positive parameter A decreases. We notice that the energy levels ε_i increase with the increasing potential parameter |A| ≥ 1, but the variation of the energy levels becomes complicated for |A| ∈(0, 1), which possesses a double well. It is seen that the energy levels ε_i increase with |A| for the parameter interval A ∈(-1, 0), while they decrease with |A| for the parameter interval A ∈(0, 1).